(Q37837738)

24 August 2017

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title

The medicinal potential of promising marine macrolides with anticancer activity (English)

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24 August 2017

Yunkun Qi

1

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24 August 2017

Shutao Ma

series ordinal

2

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24 August 2017

publication date

7 February 2011

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24 August 2017

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24 August 2017

volume

6

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24 August 2017

issue

3

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24 August 2017

page(s)

399-409

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Marine macrolides, a promising source of antitumor compounds.

24 August 2017

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Total synthesis and initial biological evaluation of new B-ring-modified bryostatin analogs.

21 January 2018

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A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma.

21 January 2018

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Phase I study of bryostatin 1, a protein kinase C modulator, preceding cisplatin in patients with refractory non-hematologic tumors

21 January 2018

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Differential effect of bryostatin 1 and phorbol 12-myristate 13-acetate on HOP-92 cell proliferation is mediated by down-regulation of protein kinase Cdelta

21 January 2018

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Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor

21 January 2018

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The antineoplastic agent bryostatin-1 differentially regulates IFN-gamma receptor subunits in monocytic cells: transcriptional and posttranscriptional control of IFN-gamma R2.

21 January 2018

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Chemistry and clinical biology of the bryostatins

21 January 2018

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Synthetic studies on the bryostatins: synthetic routes to analogues containing the tricyclic macrolactone core

21 January 2018

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Synthetic studies on the bryostatins: preparation of a truncated BC-ring intermediate by pyran annulation

21 January 2018

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Synthetic studies toward the bryostatins: a substrate-controlled approach to the A-ring

21 January 2018

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Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy

21 January 2018

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Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters

21 January 2018

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A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products

21 January 2018

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Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp.

21 January 2018

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The halichondrins and E7389.

21 January 2018

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The discovery and development of marine compounds with pharmaceutical potential

21 January 2018

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Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase

21 January 2018

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Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389

21 January 2018

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Macrocyclic ketone analogues of halichondrin B.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

Effective Procedure for Selective Ammonolysis of Monosubstituted Oxiranes: Application to E7389 Synthesis

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

Microtubule dynamics as a target in oncology

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

The place for eribulin in the treatment of metastatic breast cancer

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

The laulimalide family: total synthesis and biological evaluation of neolaulimalide, isolaulimalide, laulimalide and a nonnatural analogue.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

Laulimalide and paclitaxel: a comparison of their effects on tubulin assembly and their synergistic action when present simultaneously

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly.

21 January 2018

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Tubulin-interactive natural products as anticancer agents

21 January 2018

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Synthesis and biological evaluation of (-)-laulimalide analogues

21 January 2018

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Progress in the discovery of biosynthetic anticancer drugs

21 January 2018

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A broad-spectrum antifungal from the marine sponge Hyrtios erecta

21 January 2018

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High-resolution model of the microtubule

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

Structure of the alpha beta tubulin dimer by electron crystallography

21 January 2018

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Spongipyran Synthetic Studies. Total Synthesis of (+)-Spongistatin 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Multigram synthesis of the C29-C51 subunit and completion of the total synthesis of altohyrtin C (spongistatin 2).

21 January 2018

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Spongipyran Synthetic Studies. Evolution of a Scalable Total Synthesis of (+)-Spongistatin 1

21 January 2018

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Gram-scale synthesis of (+)-spongistatin 1: development of an improved, scalable synthesis of the F-ring subunit, fragment union, and final elaboration

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

Synthesis and biological evaluation of a spongistatin AB-spiroketal analogue

21 January 2018

1 reference

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Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Total synthesis and biological activity of neopeltolide and analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Total synthesis and stereochemical reassignment of (+)-neopeltolide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Total synthesis and structural revision of the marine macrolide neopeltolide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Total synthesis and structure-activity investigation of the marine natural product neopeltolide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Total synthesis and biological evaluation of (+)-neopeltolide and its analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Drug development from marine natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Chemistry of potent anti-cancer compounds, amphidinolides

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

Bioactive macrolides and polyketides from marine dinoflagellates of the genus Amphidinium.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

Amphidinolides, bioactive macrolides from symbiotic marine dinoflagellates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Macrolactonization via Ti(IV)-mediated epoxy-acid coupling: a total synthesis of (-)-dactylolide [and zampanolide].

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Total synthesis of (-)-dactylolide and formal synthesis of (-)-zampanolide via target oriented beta-C-glycoside formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Total synthesis of (-)-zampanolide and questionable existence of (-)-dactylolide as the elusive biosynthetic precursor of (-)-zampanolide in an Okinawan sponge

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

Antineoplastic agents. 257. Isolation and structure of spongistatin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Isolation and structure of bryostatin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

Total Synthesis of Spongistatin 1: A Synthetic Strategy Exploiting Its Latent Pseudo-Symmetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

A Concise Total Synthesis of (+)-Neopeltolide

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

21 January 2018

Marine natural products

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Marine natural products

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Exiguolide, a simplified analogue of the bryostatins by Nature?

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Norhalichondrin A: an antitumor polyether macrolide from a marine sponge

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Halichondrins - antitumor polyether macrolides from a marine sponge

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Isohomohalichondrin B, a new antitumour polyether macrolide from the New Zealand deep-water sponge Lissodendoryx sp.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Fijianolides, polyketide heterocycles from a marine sponge

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Laulimalides. New potent cytotoxic macrolides from a marine sponge and a nudibranch predator

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

New Cytotoxic Macrolides from the SpongeFasciospongia rimosa

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Dactylolide, a New Cytotoxic Macrolide from the Vanuatu SpongeDactylospongia sp.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Structures and absolute configurations of the marine toxins, latrunculin A and laulimalide

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Marine natural products: synthetic aspects

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Antineoplastic Agents 293. The Exceptional Human Cancer Cell Growth Inhibitors Spongistatins 6 and 7

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Isolation and structure of the remarkable human cancer cell growth inhibitors spongistatins 2 and 3 from an eastern indian ocean Spongia sp.

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https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Isolation and structure of the powerful human cancer cell growth inhibitors spongistatins 4 and 5 from an African Spirastrella spinispirulifera(porifera)

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Altohyrtins B and C and 5-desacetylaltohyrtin A, potent cytotoxic macrolide congeners of altohyrtin A, from the Okinawan marine sponge Hyrtios altum

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Asymmetric total synthesis of spongistatins 1 and 2

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Isolation and structure of the cancer cell growth inhibitor dictyostatin 1

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Zampanolide, a new cytotoxic marcrolide from a marine sponge

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

An expedient total synthesis of (-)-dactylolide and formal synthesis of (-)-zampanolide

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Total syntheses of (+)-zampanolide and (+)-dactylolide exploiting a unified strategy

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Total synthesis of (+)-zampanolide

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000534

7 January 2021

Identifiers

DOI

10.1002/CMDC.201000534

1 reference

24 August 2017

1 reference