(Q37843467)

24 August 2017

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title

MeCP2: structure and function (English)

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24 August 2017

Nicholas L Adkins

1

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PubMed ID

21326358

24 August 2017

Philippe T Georgel

series ordinal

2

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24 August 2017

1 February 2011

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Biochemistry and Cell Biology

24 August 2017

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24 August 2017

89

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24 August 2017

1

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24 August 2017

1-11

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Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2.

24 August 2017

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Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation

21 January 2018

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

21 January 2018

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Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells

21 January 2018

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Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer.

21 January 2018

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Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

21 January 2018

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Defining the molecular basis of Arf and Hdm2 interactions

21 January 2018

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The C-terminal domain of measles virus nucleoprotein belongs to the class of intrinsically disordered proteins that fold upon binding to their physiological partner

21 January 2018

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A WW domain binding region in methyl-CpG-binding protein MeCP2: impact on Rett syndrome

21 January 2018

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Identification of MeCP2 mutations in a series of females with autistic disorder

21 January 2018

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MeCP2, a key contributor to neurological disease, activates and represses transcription

21 January 2018

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MECP2 is highly mutated in X-linked mental retardation.

21 January 2018

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The human Mi-2/NuRD complex and gene regulation

21 January 2018

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Solution structure of the p53 regulatory domain of the p19Arf tumor suppressor protein

21 January 2018

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Differential distribution of the MeCP2 splice variants in the postnatal mouse brain

21 January 2018

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The selectivity of action of the aspartic-proteinase inhibitor IA3 from yeast (Saccharomyces cerevisiae).

21 January 2018

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The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation

21 January 2018

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Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation

21 January 2018

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IA3, an aspartic proteinase inhibitor from Saccharomyces cerevisiae, is intrinsically unstructured in solution

21 January 2018

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Rett's syndrome: prevalence and impact on progressive severe mental retardation in girls.

21 January 2018

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A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases

21 January 2018

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The phenotypic consequences of MECP2 mutations extend beyond Rett syndrome

21 January 2018

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CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

21 January 2018

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Identification and characterization of a family of mammalian methyl-CpG binding proteins

21 January 2018

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The methyl-CpG binding domain and the evolving role of DNA methylation in animals

21 January 2018

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Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes

21 January 2018

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21 January 2018

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Recent advances in MeCP2 structure and function

21 January 2018

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CpG methylation regulates the Igf2/H19 insulator

21 January 2018

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The NuRD component Mbd3 is required for pluripotency of embryonic stem cells

21 January 2018

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Genomic DNA methylation: the mark and its mediators

21 January 2018

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The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genes

21 January 2018

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The major form of MeCP2 has a novel N-terminus generated by alternative splicing

21 January 2018

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Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo

21 January 2018

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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

21 January 2018

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The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix

21 January 2018

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CoSMoS: Conserved Sequence Motif Search in the proteome

21 January 2018

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Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia

21 January 2018

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High resolution solution structure of ribosomal protein L11-C76, a helical protein with a flexible loop that becomes structured upon binding to RNA

21 January 2018

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Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs.

21 January 2018

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Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA

21 January 2018

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A mutation in the rett syndrome gene, MECP2, causes X-linked mental retardation and progressive spasticity in males

21 January 2018

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5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.

21 January 2018

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Methylation sequencing from limiting DNA: embryonic, fixed, and microdissected cells

21 January 2018

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Mutations and polymorphisms in the human methyl CpG-binding protein MECP2

21 January 2018

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A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome

21 January 2018

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The inactivating factor of glutamine synthetase, IF7, is a "natively unfolded" protein

21 January 2018

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MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin

21 January 2018

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Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

21 January 2018

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Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation

21 January 2018

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DNA methylation and chromatin modification.

21 January 2018

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Addressing the intrinsic disorder bottleneck in structural proteomics.

21 January 2018

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MECP2 mutation in male patients with non-specific X-linked mental retardation.

21 January 2018

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Direct DNA binding by Brca1

21 January 2018

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The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor

21 January 2018

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Kaiso-deficient mice show resistance to intestinal cancer

21 January 2018

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The relation of polypeptide hormone structure and flexibility to receptor binding: The relevance of X-ray studies on insulins, glucagon and human placental lactogen

21 January 2018

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Sequence complexity of disordered protein

21 January 2018

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Kaiso is a genome-wide repressor of transcription that is essential for amphibian development

21 January 2018

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Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer

21 January 2018

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Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly

21 January 2018

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Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

21 January 2018

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MECP2 structural and 3'-UTR variants in schizophrenia, autism and other psychiatric diseases: a possible association with autism

21 January 2018

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Coupling of local folding to site-specific binding of proteins to DNA

21 January 2018

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Improved in vivo dimethyl sulfate footprinting using AlkA protein: DNA-protein interactions at the mouse H19 gene promoter in primary embryo fibroblasts.

21 January 2018

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Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.

21 January 2018

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Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling

21 January 2018

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Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males

21 January 2018

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Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

21 January 2018

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The solution structure of the domain from MeCP2 that binds to methylated DNA

21 January 2018

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Angelman syndrome phenotype associated with mutations in MECP2, a gene encoding a methyl CpG binding protein

21 January 2018

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Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters

21 January 2018

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Matrix metalloproteinases in disease and repair processes in the anterior segment.

21 January 2018

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Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes

21 January 2018

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N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso

21 January 2018

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Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2.

21 January 2018

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BRCA1 physically associates with p53 and stimulates its transcriptional activity.

21 January 2018

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Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

21 January 2018

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Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function

21 January 2018

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Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

21 January 2018

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Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation

21 January 2018

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MeCP2: the chromatin connection and beyond

21 January 2018

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Folding transition in the DMA-binding domain of GCN4 on specific binding to DNA

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O10-112

1 reference

24 August 2017

1 reference

PubMed ID

21326358