(Q37844233)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21329796%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

review article

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title

Animal models in the study of the unfolded protein response (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21329796%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

2

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22 January 2020

author name string

Hemamalini Bommiasamy

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21329796%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

language of work or name

English

0 references

publication date

1 January 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21329796%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

published in

Methods in Enzymology

1 reference

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22 January 2020

volume

491

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21329796%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

page(s)

91-109

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21329796%20AND%20SRC:MED&resulttype=core&format=json

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

22 January 2020

cites work

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12 December 2020

An essential role in liver development for transcription factor XBP-1

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12 December 2020

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

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12 December 2020

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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12 December 2020

Perk is essential for translational regulation and cell survival during the unfolded protein response

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12 December 2020

Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor

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12 December 2020

ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

1 reference

12 December 2020

Regulated translation initiation controls stress-induced gene expression in mammalian cells

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12 December 2020

Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response

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12 December 2020

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

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12 December 2020

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

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12 December 2020

Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice

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12 December 2020

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

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12 December 2020

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

1 reference

12 December 2020

Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms

1 reference

12 December 2020

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

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12 December 2020

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

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12 December 2020

Plasma cell differentiation requires the transcription factor XBP-1

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12 December 2020

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

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12 December 2020

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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12 December 2020

Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice.

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12 December 2020

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

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12 December 2020

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

1 reference

12 December 2020

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

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12 December 2020

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

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12 December 2020

The unfolded protein response modulates disease severity in Pelizaeus-Merzbacher disease.

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12 December 2020

Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.

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12 December 2020

P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling

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12 December 2020

Stress-induced gene expression requires programmed recovery from translational repression

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12 December 2020

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

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12 December 2020

Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis

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12 December 2020

The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice

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12 December 2020

Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress

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12 December 2020

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

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12 December 2020

A transgenic mouse model for monitoring endoplasmic reticulum stress

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12 December 2020

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

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12 December 2020

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

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12 December 2020

XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

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12 December 2020

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

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12 December 2020

The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.

1 reference

12 December 2020

IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors

1 reference

12 December 2020

Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK

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12 December 2020

Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma

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12 December 2020

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

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12 December 2020

XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells

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12 December 2020

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

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12 December 2020

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

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12 December 2020

In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4.

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12 December 2020

Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload

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12 December 2020

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

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12 December 2020

The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage

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12 December 2020

PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice

1 reference

12 December 2020

ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress

1 reference

12 December 2020

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

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12 December 2020

The transcription factor XBP-1 is essential for the development and survival of dendritic cells

1 reference

12 December 2020

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.

1 reference

12 December 2020

Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice

1 reference

12 December 2020

Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice

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12 December 2020

Regulation of hepatic lipogenesis by the transcription factor XBP1

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12 December 2020

PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation.

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12 December 2020

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

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12 December 2020

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

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12 December 2020

Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma

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12 December 2020

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

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12 December 2020

Endoplasmic reticulum stress in disorders of myelinating cells.

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12 December 2020

Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.

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12 December 2020

Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis

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12 December 2020

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

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12 December 2020

Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress

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12 December 2020

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

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12 December 2020

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1 reference

12 December 2020

The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation

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12 December 2020

Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus

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12 December 2020

Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

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12 December 2020

Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells

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12 December 2020

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

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12 December 2020

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

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12 December 2020

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

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12 December 2020

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

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12 December 2020

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1 reference

12 December 2020

10.1016/B978-0-12-385928-0.00006-7

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21329796%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21329796%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference