(Q37847687)

24 August 2017

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title

Pulmonary delivery of therapeutic siRNA. (English)

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24 August 2017

3

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24 August 2017

Jenny Ka-Wing Lam

1

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author name string

Wanling Liang

series ordinal

2

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24 August 2017

language of work or name

English

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publication date

26 February 2011

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Advanced Drug Delivery Reviews

24 August 2017

published in

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24 August 2017

volume

64

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24 August 2017

issue

1

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24 August 2017

page(s)

1-15

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Attenuation of fibrosis in vitro and in vivo with SPARC siRNA

24 August 2017

cites work

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12 December 2020

Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation

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12 December 2020

Insight into the cellular uptake mechanism of a secondary amphipathic cell-penetrating peptide for siRNA delivery.

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12 December 2020

Biodegradable nanoparticles for drug and gene delivery to cells and tissue

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12 December 2020

Prospects of formulating proteins/peptides as aerosols for pulmonary drug delivery

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12 December 2020

The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing.

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12 December 2020

Design and evaluation of histidine-rich amphipathic peptides for siRNA delivery

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12 December 2020

RNA interference is mediated by 21- and 22-nucleotide RNAs

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12 December 2020

Safety and efficacy of inhaled human insulin (exubera) during discontinuation and readministration of therapy in adults with type 2 diabetes: a 3-year randomized controlled trial

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12 December 2020

siRNA delivery using peptide transduction domains

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12 December 2020

Exubera inhaled insulin in patients with type 1 and type 2 diabetes: the first 12 months.

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12 December 2020

Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells.

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12 December 2020

Progress towards in vivo use of siRNAs

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12 December 2020

Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles

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12 December 2020

RNA interference: listening to the sound of silence

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12 December 2020

In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury

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12 December 2020

A clinical inflammatory syndrome attributable to aerosolized lipid-DNA administration in cystic fibrosis

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12 December 2020

Protection against lethal influenza virus challenge by RNA interference in vivo.

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12 December 2020

Formation, characterization, and fate of inhaled drug nanoparticles

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12 December 2020

Membrane-permeable arginine-rich peptides and the translocation mechanisms

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12 December 2020

Adenovirus vector-mediated doxycycline-inducible RNA interference

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12 December 2020

Inhaled mannitol improves the hydration and surface properties of sputum in patients with cystic fibrosis

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12 December 2020

Inhaled insulin is approved in Europe and United States

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12 December 2020

Gene transfer to the lung: lessons learned from more than 2 decades of CF gene therapy

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12 December 2020

Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures

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12 December 2020

Efficient gene silencing in lungs and liver using imidazole-modified chitosan as a nanocarrier for small interfering RNA.

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12 December 2020

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

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12 December 2020

Identification of novel superior polycationic vectors for gene delivery by high-throughput synthesis and screening of a combinatorial library

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12 December 2020

Ocular biodistribution of bevasiranib following a single intravitreal injection to rabbit eyes

1 reference

12 December 2020

Large porous particles for pulmonary drug delivery

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12 December 2020

Cellular uptake of the tat protein from human immunodeficiency virus

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12 December 2020

Nucleic acid delivery with chitosan and its derivatives

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12 December 2020

Development and characterisation of chitosan nanoparticles for siRNA delivery

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12 December 2020

Lipid-based systemic delivery of siRNA.

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12 December 2020

Poly(ester amine)-mediated, aerosol-delivered Akt1 small interfering RNA suppresses lung tumorigenesis

1 reference

12 December 2020

A new potent secondary amphipathic cell-penetrating peptide for siRNA delivery into mammalian cells

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12 December 2020

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

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12 December 2020

Immunological and toxicological implications of short-term studies in animals of pharmaceutical aerosol delivery to the lungs: relevance to humans.

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12 December 2020

RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

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12 December 2020

Intranasal insulin delivery and therapy

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12 December 2020

Gene silencing by adenovirus-delivered siRNA.

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12 December 2020

Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives

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12 December 2020

Cell-penetrating peptides.

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12 December 2020

Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models.

1 reference

12 December 2020

Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis

1 reference

12 December 2020

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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12 December 2020

Poly(beta-amino ester) as a carrier for si/shRNA delivery in lung cancer cells

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12 December 2020

Immune responses to gene therapy vectors: influence on vector function and effector mechanisms

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12 December 2020

Gene therapy for human small-cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference

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12 December 2020

Occurrence of leukaemia following gene therapy of X-linked SCID.

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12 December 2020

Gene therapy. Second child in French trial is found to have leukemia

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12 December 2020

Effective treatment of respiratory alphaherpesvirus infection using RNA interference.

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12 December 2020

Adenovirus-mediated transfer of siRNA against survivin enhances the radiosensitivity of human non-small cell lung cancer cells

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12 December 2020

In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery

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12 December 2020

Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

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12 December 2020

RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027.

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12 December 2020

Interaction of bronchoalveolar lavage fluid with polyplexes and lipoplexes: analysing the role of proteins and glycoproteins

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12 December 2020

Inhalable lactose-based dry powder formulations of low molecular weight heparin.

1 reference

12 December 2020

shRNAs targeting hepatitis C: effects of sequence and structural features, and comparision with siRNA.

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12 December 2020

Nanodelivery in airway diseases: challenges and therapeutic applications

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12 December 2020

Efficacy and safety of inhaled insulin (exubera) compared with subcutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, comparative trial

1 reference

12 December 2020

Efficacy and safety of inhaled insulin (Exubera) compared with subcutaneous insulin therapy in patients with type 1 diabetes: results of a 6-month, randomized, comparative trial

1 reference

12 December 2020

RNA interference advances to early-stage clinical trials

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12 December 2020

Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis

1 reference

12 December 2020

Cellular delivery of small interfering RNA by a non-covalently attached cell-penetrating peptide: quantitative analysis of uptake and biological effect

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12 December 2020

Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers

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12 December 2020

Evaluation of Aerosol Delivery of Nanosuspension for Pre-clinical Pulmonary Drug Delivery

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12 December 2020

Inhibition of influenza virus production in virus-infected mice by RNA interference

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12 December 2020

Extracellular barriers in respiratory gene therapy.

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12 December 2020

Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations

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12 December 2020

Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice

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12 December 2020

Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial.

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12 December 2020

RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA.

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12 December 2020

Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms

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12 December 2020

Spray-drying preparation of microparticles containing cationic PLGA nanospheres as gene carriers for avoiding aggregation of nanospheres.

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12 December 2020

Small interfering RNA against interleukin-5 decreases airway eosinophilia and hyper-responsiveness.

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12 December 2020

Inhibition of respiratory viruses by nasally administered siRNA.

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12 December 2020

Involvement of Syk kinase in TNF-induced nitric oxide production by airway epithelial cells.

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12 December 2020

Down-regulation of expression of rat pyruvate dehydrogenase E1alpha gene by self-complementary adeno-associated virus-mediated small interfering RNA delivery

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12 December 2020

Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

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12 December 2020

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

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12 December 2020

RNAi-mediated gene silencing in non-human primates.

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12 December 2020

Intracellular siRNA delivery system using polyelectrolyte complex micelles prepared from VEGF siRNA-PEG conjugate and cationic fusogenic peptide

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12 December 2020

Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis

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12 December 2020

Small RNAs and non-small cell lung cancer

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12 December 2020

Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery

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12 December 2020

Lipid-like materials for low-dose, in vivo gene silencing

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12 December 2020

RNA interference: new therapeutics in allergic diseases

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12 December 2020

Rational design of cationic lipids for siRNA delivery

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12 December 2020

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

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12 December 2020

RNA interference of avian influenza virus H5N1 by inhibiting viral mRNA with siRNA expression plasmids

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12 December 2020

Clinical evaluation of inhaled insulin

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12 December 2020

Systemic delivery of parathyroid hormone (1-34) using inhalation dry powders in rats

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12 December 2020

Using magnetic forces to enhance non-viral gene transfer to airway epithelium in vivo

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12 December 2020

WT1 gene silencing by aerosol delivery of PEI-RNAi complexes inhibits B16-F10 lung metastases growth

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12 December 2020

Intranasal drug delivery

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12 December 2020

RNA interference: biology, mechanism, and applications

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12 December 2020

Emerging oligonucleotide therapies for asthma and chronic obstructive pulmonary disease

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12 December 2020

Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes

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12 December 2020

Inhalation of dry-powder mannitol increases mucociliary clearance

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12 December 2020

The lung as a route for systemic delivery of therapeutic proteins and peptides

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12 December 2020

Non-viral siRNA delivery to the lung

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12 December 2020

Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis.

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12 December 2020

Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation.

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12 December 2020

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12 December 2020

NanoCipro encapsulation in monodisperse large porous PLGA microparticles

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12 December 2020

Pulmonary surfactant inhibits cationic liposome-mediated gene delivery to respiratory epithelial cells in vitro

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12 December 2020

Multifunctional siRNA delivery system: polyelectrolyte complex micelles of six-arm PEG conjugate of siRNA and cell penetrating peptide with crosslinked fusogenic peptide.

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12 December 2020

Expression of respiratory mucins in fatal status asthmaticus and mild asthma.

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12 December 2020

Effect of increasing doses of mannitol on mucus clearance in patients with bronchiectasis

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12 December 2020

Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications.

1 reference

12 December 2020

Gene silencing in mammals by small interfering RNAs

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12 December 2020

RNA interference and innate immunity

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12 December 2020

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

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12 December 2020

Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers

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12 December 2020

Oxygen radical-mediated pulmonary toxicity induced by some cationic liposomes

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12 December 2020

Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells

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12 December 2020

Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides

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12 December 2020

Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.

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12 December 2020

Mucus clearance as a primary innate defense mechanism for mammalian airways

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12 December 2020

Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity.

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12 December 2020

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

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12 December 2020

Single-nucleotide-specific siRNA targeting in a dominant-negative skin model

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12 December 2020

Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells

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12 December 2020

A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.

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12 December 2020

Chitosan-based formulations for delivery of DNA and siRNA.

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12 December 2020

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV).

1 reference

12 December 2020

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

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12 December 2020

Cell-penetrating-peptide-mediated siRNA lung delivery

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12 December 2020

Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium

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12 December 2020

Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles

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12 December 2020

RNA interference-mediated silencing of the respiratory syncytial virus nucleocapsid defines a potent antiviral strategy

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12 December 2020

Chemically modified siRNA: tools and applications.

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12 December 2020

Potency of siRNA versus shRNA mediated knockdown in vivo

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12 December 2020

RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system.

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12 December 2020

Antisense RNA: function and fate of duplex RNA in cells of higher eukaryotes.

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12 December 2020

Gene therapy insertional mutagenesis insights

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12 December 2020

Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1.

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12 December 2020

Use of ultrasound to enhance nonviral lung gene transfer in vivo

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12 December 2020

Targeted delivery of magnetic aerosol droplets to the lung

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12 December 2020

Intratracheal versus intravenous liposomal delivery of siRNA, antisense oligonucleotides and anticancer drug

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12 December 2020

Cell-penetrating peptides: tools for intracellular delivery of therapeutics.

1 reference

12 December 2020

Efficacy of inhaled insulin in patients with type 2 diabetes not controlled with diet and exercise: a 12-week, randomized, comparative trial

1 reference

12 December 2020

Visualizing a Correlation between siRNA Localization, Cellular Uptake, and RNAi in Living Cells

1 reference

12 December 2020

Tat peptide-mediated cellular delivery: back to basics

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12 December 2020

Non-invasive pulmonary aerosol delivery in mice by the endotracheal route

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12 December 2020

First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder.

1 reference

12 December 2020

Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression.

1 reference

12 December 2020

Inhaled insulin's last gasp?

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12 December 2020

Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance.

1 reference

12 December 2020

Inhalable large porous microspheres of low molecular weight heparin: in vitro and in vivo evaluation

1 reference

12 December 2020

RNAi-mediated suppression of constitutive pulmonary gene expression by small interfering RNA in mice.

1 reference

12 December 2020

Inhaled nanoparticles--a current review.

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12 December 2020

Inhibition of non-small cell lung cancer cell proliferation and tumor growth by vector-based small interfering RNAs targeting HER2/neu

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12 December 2020

Delivery vehicles for small interfering RNA in vivo

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12 December 2020

Pulmonary delivery of therapeutic peptides via dry powder inhalation: effects of micronisation and manufacturing

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12 December 2020

Lipidic systems for in vivo siRNA delivery

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12 December 2020

Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer.

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12 December 2020

Innate sensing of self and non-self RNAs by Toll-like receptors

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12 December 2020

Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action

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12 December 2020

10.1016/J.ADDR.2011.02.006

Identifiers

DOI

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24 August 2017

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