(Q37848652)

24 August 2017

1 reference

title

The biological and therapeutic relevance of mRNA translation in cancer (English)

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24 August 2017

Sarah P Blagden

1

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24 August 2017

Anne E Willis

series ordinal

2

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24 August 2017

language of work or name

English

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publication date

1 March 2011

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Nature Reviews Clinical Oncology

24 August 2017

published in

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24 August 2017

volume

8

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24 August 2017

issue

5

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24 August 2017

page(s)

280-291

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Genetic regulatory mechanisms in the synthesis of proteins

24 August 2017

cites work

2 references

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A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation

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Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages

21 January 2018

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The mechanism of eukaryotic translation initiation and principles of its regulation

21 January 2018

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Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein

21 January 2018

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Re-programming of translation following cell stress allows IRES-mediated translation to predominate

21 January 2018

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The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr

21 January 2018

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The implications of structured 5' untranslated regions on translation and disease

21 January 2018

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Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry

21 January 2018

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Canonical initiation factor requirements of the Myc family of internal ribosome entry segments

21 January 2018

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Diverse poly(A) binding proteins mediate internal translational initiation by a plant viral IRES.

21 January 2018

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Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

21 January 2018

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Eukaryotic translation initiation factors and regulators

21 January 2018

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

21 January 2018

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eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver

21 January 2018

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4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

21 January 2018

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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

21 January 2018

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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

21 January 2018

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Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?

21 January 2018

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4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors

21 January 2018

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Estrogen-induced activation of extracellular signal-regulated kinase signaling triggers dendritic resident mRNA translation

21 January 2018

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Translational control by MAPK signaling in long-term synaptic plasticity and memory

21 January 2018

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Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

21 January 2018

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Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Phosphorylated 4E-BP1 is associated with poor survival in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mammalian target of rapamycin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Eukaryotic initiation factor-4E in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor expression and tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Overexpression of eukaryotic initiation factor 4E (eIF4E) and its clinical significance in lung adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

eIF4E: new family members, new binding partners, new roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Cloning and characterization of human eIF4E genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Structural basis for inhibition of translation by the tumor suppressor Pdcd4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Differential efficiencies of in vitro translation of mouse c-myc transcripts differing in the 5' untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cellsin vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Translation initiation factor eIF-4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

eIF3: a connecTOR of S6K1 to the translation preinitiation complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Individual overexpression of five subunits of human translation initiation factor eIF3 promotes malignant transformation of immortal fibroblast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Targeting translation for treatment of cancer--a novel role for IRES?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

The role of the 5' untranslated region of an mRNA in translation regulation during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: a novel mechanism of oncogene de-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Novel dyskerin-mediated mechanism of p53 inactivation through defective mRNA translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Repression of cap-dependent translation attenuates the transformed phenotype in non-small cell lung cancer both in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Dissecting eIF4E action in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

MNK, EIF4E and targeting translation for therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin's lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Visibly stressed: the role of eIF2, TIA-1, and stress granules in protein translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

The chemotherapeutic agent bortezomib induces the formation of stress granules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Uncoupling stress granule assembly and translation initiation inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP, and eIF4G conferred by internal ribosome entry sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Signaling the unfolded protein response from the endoplasmic reticulum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Cigarette smoke induces an unfolded protein response in the human lung: a proteomic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Activation and clinical significance of the unfolded protein response in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Overexpression of endoplasmic reticulum molecular chaperone GRP94 and GRP78 in human lung cancer tissues and its significance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Grp78 promotes the invasion of hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Untangling the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

FDA approval summary: temsirolimus as treatment for advanced renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Phase II study of erlotinib in recurrent or metastatic endometrial cancer: NCIC IND-148.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

A randomized, phase II trial of two dose levels of temsirolimus (CCI-779) in patients with extensive-stage small-cell lung cancer who have responding or stable disease after induction chemotherapy: a trial of the Eastern Cooperative Oncology Group (

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

The pharmacology of mTOR inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Biological barriers to therapy with antisense and siRNA oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Antisense and/or immunostimulatory oligonucleotide therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Further evidence that ribavirin interacts with eIF4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Ribavirin is not a functional mimic of the 7-methyl guanosine mRNA cap.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Inhibition of eukaryotic translation initiation by the marine natural product pateamine A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Selective pharmacological targeting of a DEAD box RNA helicase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Efficient Synthetic Approach to Potent Antiproliferative Agent Hippuristanol via Hg(II)-Catalyzed Spiroketalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Expeditious synthesis of hippuristanol and congeners with potent antiproliferative activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Strategy to induce apoptosis and circumvent resistance in chronic lymphocytic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Potential of plant-derived natural products in the treatment of leukemia and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

MicroRNAs in tumorigenesis: a primer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Targeting microRNAs in cancer: rationale, strategies and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Altering chemosensitivity by modulating translation elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

DCB-3503, a tylophorine analog, inhibits protein synthesis through a novel mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Termination of translation in eukaryotes is mediated by the quaternary eRF1*eRF3*GTP*Mg2+ complex. The biological roles of eRF3 and prokaryotic RF3 are profoundly distinct

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Differential expression of the eukaryotic release factor 3 (eRF3/GSPT1) according to gastric cancer histological types.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Effect on tumor cells of blocking survival response to glucose deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

An unstable intermediate carrying information from genes to ribosomes for protein synthesis

21 January 2018

2 references

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

21 January 2018

12 December 2020

The relation of informational RNA to DNA

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

ERK and mTOR signaling couple beta-adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent long-term potentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Elevated expression of eIF4E in confined early breast cancer lesions: possible role of hypoxia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

eIF4E as a marker for cervical neoplasia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Dynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Biochemical and kinetic characterization of the RNA helicase activity of eukaryotic initiation factor 4A

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

p150 overexpression in gastric carcinoma: the association with p53, apoptosis and cell proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

4E binding protein 1 expression is inversely correlated to the progression of gastrointestinal cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Expression of eukaryotic translation initiation factors 4E and 2alpha is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Expression of eukaryotic translation initiation factors 4E and 2alpha correlates with the progression of thyroid carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Levels, phosphorylation status and cellular localization of translational factor eIF2 in gastrointestinal carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Phosphorylation of eIF-4E on Ser 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Pateamine: a potent cytotoxin from the New Zealand Marine sponge, mycale sp.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

RNA-Mediated Sequestration of the RNA Helicase eIF4A by Pateamine A Inhibits Translation Initiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

New cytotoxic steroids from the gorgonian Isis hippuris . Structure–activity studies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

How do microRNAs regulate gene expression?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.16

Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon

31 March 2020

1 reference

12 December 2020

Characterization of programmed cell death 4 in multiple human cancers reveals a novel enhancer of drug sensitivity

1 reference

12 December 2020

Mechanism of action and regulation of protein synthesis initiation factor 4E: effects on mRNA discrimination, cellular growth rate, and oncogenesis.

1 reference

12 December 2020

The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth

1 reference

12 December 2020

Expression levels of eIF4E, VEGF, and cyclin D1, and correlation of eIF4E with VEGF and cyclin D1 in multi-tumor tissue microarray

1 reference

12 December 2020

Translational control of malignancy: the mRNA cap-binding protein, eIF-4E, as a central regulator of tumor formation, growth, invasion and metastasis

1 reference

12 December 2020

Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro

1 reference

12 December 2020

Overexpression of p150, a part of the large subunit of the eukaryotic translation initiation factor 3, in colon cancer

1 reference

12 December 2020

Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cel

1 reference

12 December 2020

Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity

1 reference

12 December 2020

Enhanced expression of translation factor mRNAs in hepatocellular carcinoma.

1 reference

12 December 2020

Malignant transformation by overproduction of translation initiation factor eIF4G.

1 reference

12 December 2020

10.1038/NRCLINONC.2011.16

Identifiers

DOI

1 reference

24 August 2017

1 reference