(Q37848839)

24 August 2017

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title

Therapeutic prospects for epigenetic modulation (English)

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24 August 2017

Tom D Heightman

1

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24 August 2017

language of work or name

English

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publication date

3 March 2011

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Expert Opinion on Therapeutic Targets

24 August 2017

published in

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24 August 2017

volume

15

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24 August 2017

issue

6

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24 August 2017

page(s)

729-740

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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Genomic DNA methylation: the mark and its mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Chromatin modifications and their function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

The impact of microRNAs on protein output

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

The non-coding Air RNA is required for silencing autosomal imprinted genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Evidence for X-chromosomal schizophrenia associated with microRNA alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Epigenetic reprogramming during early development in mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Histone deacetylase activity is required for embryonic stem cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Effect of in utero and early-life conditions on adult health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Obesity in young men after famine exposure in utero and early infancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

One-carbon metabolism in psychiatric illness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Regulation of hippocampal H3 histone methylation by acute and chronic stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Epigenetic differences arise during the lifetime of monozygotic twins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Epigenetic memory in induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

DNA methylation and gene silencing in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Histone deacetylase inhibitors: from bench to clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Rational combinations using HDAC inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

The polycomb group protein EZH2 is involved in progression of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

The emerging field of dynamic lysine methylation of non-histone proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

hDOT1L links histone methylation to leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Bromodomain 4 activation predicts breast cancer survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Midline carcinoma of children and young adults with NUT rearrangement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Environmental epigenetics of asthma: An update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Epigenetic control in rheumatoid arthritis synovial fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Improved transplantation outcome by epigenetic changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

HDAC inhibitors as anti-inflammatory agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Suppression of inflammation by a synthetic histone mimic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Epigenetic regulation in psychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Epigenetics, DNA methylation, and chromatin modifying drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Epigenetic regulation in the pathophysiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Histone deacetylase inhibitors: possible implications for neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Histone deacetylase 6 interacts with the microtubule-associated protein tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

HDAC2 negatively regulates memory formation and synaptic plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

The genetics and epigenetics of autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Epigenetics: a molecular link between environmental factors and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

The EBNA1 protein of Epstein-Barr virus functionally interacts with Brd4

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

SIRT1 regulates HIV transcription via Tat deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Specific inhibition of p300-HAT alters global gene expression and represses HIV replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Targeting DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Histone acetyltransferase inhibitors and preclinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

Histone deacetylase inhibitors: molecular mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561786

In utero supplementation with methyl donors enhances allergic airway disease in mice

21 January 2018

1 reference

9 February 2024

https://opencitations.net/index/api/v1/citations/10.1172/JCI34378

Identifiers

DOI

10.1517/14728222.2011.561786

1 reference

24 August 2017

1 reference