(Q37851981)

24 August 2017

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title

Toward a new age of cellular pharmacokinetics in drug discovery (English)

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24 August 2017

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Fang Zhou

1

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24 August 2017

Jingwei Zhang

2

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24 August 2017

Peng Li

3

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24 August 2017

Fang Niu

4

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24 August 2017

Xiaolan Wu

5

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24 August 2017

Guangji Wang

6

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24 August 2017

Michael S Roberts

7

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24 August 2017

language of work or name

English

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publication date

11 March 2011

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24 August 2017

published in

Drug Metabolism Reviews

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24 August 2017

volume

43

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24 August 2017

issue

3

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24 August 2017

page(s)

335-345

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Defective acidification in human breast tumor cells and implications for chemotherapy.

24 August 2017

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Novel steroid carbamates reverse multidrug-resistance in cancer therapy and show linkage among efficacy, loci of drug action and P-glycoprotein's cellular localization

21 January 2018

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Response of cultured macrophages to Mycobacterium tuberculosis, with observations on fusion of lysosomes with phagosomes

21 January 2018

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Cellular pharmacokinetics of telavancin, a novel lipoglycopeptide antibiotic, and analysis of lysosomal changes in cultured eukaryotic cells (J774 mouse macrophages and rat embryonic fibroblasts).

21 January 2018

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Determination of intracellular organelles implicated in daunorubicin cytoplasmic sequestration in multidrug-resistant MCF-7 cells using fluorescence microscopy image analysis

21 January 2018

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Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas

21 January 2018

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A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group

21 January 2018

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Intracellular accumulation and activity of ampicillin used as free drug and as its phthalimidomethyl or pivaloyloxymethyl ester (pivampicillin) against Listeria monocytogenes in J774 macrophages

21 January 2018

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Proton pump inhibitors may reduce tumour resistance

21 January 2018

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Intracellular drug sequestration events associated with the emergence of multidrug resistance: a mechanistic review

21 January 2018

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Coordinate transcriptional regulation of transport and metabolism

21 January 2018

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Separate Roles for the Golgi Apparatus and Lysosomes in the Sequestration of Drugs in the Multidrug-resistant Human Leukemic Cell Line HL-60

21 January 2018

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Identification of the subcellular localization of daunorubicin in multidrug-resistant K562 cell line

21 January 2018

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Multidrug resistance in cancer: role of ATP-dependent transporters

21 January 2018

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Prodrug chemotherapeutics bypass p-glycoprotein resistance and kill tumors in vivo with high efficacy and target-dependent selectivity

21 January 2018

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Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone

21 January 2018

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Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors

21 January 2018

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Hepatic pharmacokinetics of taurocholate in the normal and cholestatic rat liver

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Physiologically based synthetic models of hepatic disposition

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Thymidine phosphorylase and dihydropyrimidine dehydrogenase activity in colorectal carcinoma and patients prognosis

21 January 2018

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Enzyme induction in cryopreserved human hepatocyte cultures

21 January 2018

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Influence of the prodrugs 5-fluorocytosine and CPT-11 on ovarian cancer cells using genetically engineered stem cells: tumor-tropic potential and inhibition of ovarian cancer cell growth.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Modulation of oral drug bioavailability: from preclinical mechanism to therapeutic application

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Resistance mechanisms associated with altered intracellular distribution of anticancer agents.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Screening for human ADME/Tox drug properties in drug discovery

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Liver transporters in hepatic drug disposition: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Efficient intracellular delivery of rifampicin to alveolar macrophages using rifampicin-loaded PLGA microspheres: effects of molecular weight and composition of PLGA on release of rifampicin

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Role of the lung resistance-related protein (LRP) in the drug sensitivity of cultured tumor cells.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Tumoral drug metabolism: overview and its implications for cancer therapy

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Drug metabolism by tumours: its nature, relevance and therapeutic implications

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Prediction of response to docetaxel by CYP3A4 mRNA expression in breast cancer tissues

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Detection of P-glycoprotein in the Golgi apparatus of drug-untreated human melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Mitochondrial localization and activity of P-glycoprotein in doxorubicin-resistant K562 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Targeting lipophilic cations to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Targeting antioxidants to mitochondria by conjugation to lipophilic cations.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Mycobacterium tuberculosis resides in nonacidified vacuoles in endocytically competent alveolar macrophages from patients with tuberculosis and HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Nuclear receptor-mediated transcriptional regulation in Phase I, II, and III xenobiotic metabolizing systems

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Predictive factors for response to docetaxel in human breast cancers

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Inhibitors of vacuolar H+-ATPase impair the preferential accumulation of daunomycin in lysosomes and reverse the resistance to anthracyclines in drug-resistant renal epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Discrepancy between uptake and intracellular activity of moxifloxacin in a Staphylococcus aureus-human THP-1 monocytic cell model

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

In vivo and in vitro anti-cancer activities and enhanced cellular uptakes of EGF fragment decorated doxorubicin nano-aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Fluoxetine inhibits multidrug resistance extrusion pumps and enhances responses to chemotherapy in syngeneic and in human xenograft mouse tumor models

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Multidrug resistance: retrospect and prospects in anti-cancer drug treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Gentamicin-loaded microspheres for reducing the intracellular Brucella abortus load in infected monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Subcellular localization and activity of multidrug resistance proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Influence of conversion of penicillin G into a basic derivative on its accumulation and subcellular localization in cultured macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Accumulation of lipophilic dications by mitochondria and cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Membrane potential and surface potential in mitochondria: uptake and binding of lipophilic cations.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Activation of oxazaphosphorines by cytochrome P450: application to gene-directed enzyme prodrug therapy for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Targeted enzyme prodrug therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in adriamycin-resistant cells (MCF-7adr).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Influence of P-glycoprotein and MRP efflux pump inhibitors on the intracellular activity of azithromycin and ciprofloxacin in macrophages infected by Listeria monocytogenes or Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Enhanced tumor therapy using vaccinia virus strain GLV-1h68 in combination with a β-galactosidase-activatable prodrug seco-analog of duocarmycin SA

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Ion-trapping, microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Preclinical pharmacokinetics: an approach towards safer and efficacious drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Quantitative modeling of selective lysosomal targeting for drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Estimating human drug oral absorption kinetics from Caco-2 permeability using an absorption-disposition model: model development and evaluation and derivation of analytical solutions for k(a) and F(a).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Drug uptake systems in liver and kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Efflux kinetics and intracellular distribution of daunorubicin are not affected by major vault protein/lung resistance-related protein (vault) expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

21 January 2018

Capecitabine: a review

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

The therapeutic response to multifunctional polymeric nano-conjugates in the targeted cellular and subcellular delivery of doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

A cell-based molecular transport simulator for pharmacokinetic prediction and cheminformatic exploration.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560607

10.3109/03602532.2011.560607

21 January 2018

Identifiers

DOI

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24 August 2017

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