(Q37855840)

24 August 2017

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title

The Mycobacterium tuberculosis cytochromes P450: physiology, biochemistry & molecular intervention (English)

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Mycobacterium tuberculosis

24 August 2017

main subject

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physiology

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author name string

Kirsty J McLean

1

1 reference

24 August 2017

James Belcher

2

1 reference

24 August 2017

Max D Driscoll

3

1 reference

24 August 2017

Christine C Fernandez

4

1 reference

24 August 2017

Duyet Le Van

5

1 reference

24 August 2017

Soi Bui

6

1 reference

24 August 2017

Marina Golovanova

7

1 reference

24 August 2017

Andrew W Munro

8

1 reference

24 August 2017

publication date

1 August 2010

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Future Medicinal Chemistry

24 August 2017

published in

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24 August 2017

volume

2

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24 August 2017

issue

8

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24 August 2017

page(s)

1339-1353

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Multidrug-resistant tuberculosis (MDR-TB): epidemiology, prevention and treatment

24 August 2017

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EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme

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Structural characterization of a novel sulfated menaquinone produced by stf3 from Mycobacterium tuberculosis

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Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions

21 January 2018

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Genes required for mycobacterial growth defined by high density mutagenesis

21 January 2018

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Genetic requirements for mycobacterial survival during infection

21 January 2018

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Small-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray Crystallography

21 January 2018

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Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit

21 January 2018

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The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection

21 January 2018

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Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids

21 January 2018

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A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages

21 January 2018

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21 January 2018

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Mycobacterial persistence requires the utilization of host cholesterol

21 January 2018

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Serum total cholesterol, HDL-C and LDL-C concentrations significantly correlate with the radiological extent of disease and the degree of smear positivity in patients with pulmonary tuberculosis.

21 January 2018

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Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum

21 January 2018

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Cholesterol-sensor initiates M. tuberculosis entry into human macrophages

21 January 2018

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Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence

21 January 2018

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The surface of lipid droplets is a phospholipid monolayer with a unique Fatty Acid composition

21 January 2018

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Essential role for cholesterol in entry of mycobacteria into macrophages

21 January 2018

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Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Dormancy phenotype displayed by extracellular Mycobacterium tuberculosis within artificial granulomas in mice

21 January 2018

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Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling

21 January 2018

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Transcriptomic analysis identifies growth rate modulation as a component of the adaptation of mycobacteria to survival inside the macrophage.

21 January 2018

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Cytochrome P450 125 (CYP125) catalyses C26-hydroxylation to initiate sterol side-chain degradation in Rhodococcus jostii RHA1.

21 January 2018

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Rapid and spontaneous loss of phthiocerol dimycocerosate (PDIM) from Mycobacterium tuberculosis grown in vitro: implications for virulence studies

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.216

Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.216

Structure and chemistry of cytochrome P450.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.216

Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes

21 January 2018

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Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.216

Characterization of Active Site Structure in CYP121: A CYTOCHROME P450 ESSENTIAL FOR VIABILITY OF MYCOBACTERIUM TUBERCULOSIS H37Rv

21 January 2018

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A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis

21 January 2018

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Functional and evolutionary genomics of Mycobacterium tuberculosis: insights from genomic deletions in 100 strains

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.216

Gene expression diversity among Mycobacterium tuberculosis clinical isolates.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.216

Mycobacterium tuberculosis CYP130: CRYSTAL STRUCTURE, BIOPHYSICAL CHARACTERIZATION, AND INTERACTIONS WITH ANTIFUNGAL AZOLE DRUGS

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.216

Interaction of Mycobacterium tuberculosis CYP130 with Heterocyclic Arylamines

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.216

Cytochrome P450 activation of arylamines and heterocyclic amines

21 January 2018

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Biochemical and structural characterization of CYP124: A methyl-branched lipid -hydroxylase from Mycobacterium tuberculosis

21 January 2018

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Managing TB in the 21st century: existing and novel drug therapies

21 January 2018

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Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes

21 January 2018

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The potential of azole antifungals against latent/persistent tuberculosis

21 January 2018

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In vitro and ex vivo antimycobacterial potential of azole drugs against Mycobacterium tuberculosis H37Rv

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.216

Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.216

Synthesis and antitubercular screening of imidazole derivatives.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.216

Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5-MmpL5 efflux system

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.216

New generation azole antifungals in clinical investigation

21 January 2018

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Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.216

Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.216

Estriol bound and ligand-free structures of sterol 14alpha-demethylase

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.216

After decades of drought, new drug possibilities flood TB pipeline

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.216

A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.10.216

1 reference

24 August 2017

1 reference