(Q37855844)

24 August 2017

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title

In vitro safety pharmacology profiling: what else beyond hERG? (English)

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24 August 2017

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Jacques Hamon

1

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24 August 2017

Steven Whitebread

2

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24 August 2017

Valerie Techer-Etienne

3

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24 August 2017

Helene Le Coq

4

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24 August 2017

Kamal Azzaoui

5

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24 August 2017

Laszlo Urban

6

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24 August 2017

publication date

1 July 2009

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Future Medicinal Chemistry

24 August 2017

published in

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24 August 2017

volume

1

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24 August 2017

issue

4

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24 August 2017

page(s)

645-665

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Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development

24 August 2017

cites work

1 reference

Why drugs fail--a study on side effects in new chemical entities.

21 January 2018

1 reference

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

The hERG channel and risk of drug-acquired cardiac arrhythmia: an overview

21 January 2018

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Target validation of G-protein coupled receptors

21 January 2018

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Dopamine receptor signaling

21 January 2018

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Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders

21 January 2018

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Parkinson's disease: levodopa-induced dyskinesia and signal transduction.

21 January 2018

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Effects of dopamine D1 ligands on eye blinking in monkeys: efficacy, antagonism, and D1/D2 interactions

21 January 2018

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Dopamine receptors and hypertension

21 January 2018

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A comparison of fenoldopam with dopamine and sodium nitroprusside in patients undergoing cross-clamping of the abdominal aorta

21 January 2018

1 reference

Randomized controlled trials of the D1/D5 antagonist ecopipam for weight loss in obese subjects

21 January 2018

1 reference

Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics

21 January 2018

1 reference

Pathological gambling caused by drugs used to treat Parkinson disease

21 January 2018

1 reference

Histamine and its receptors

21 January 2018

1 reference

Alpha 1-adrenergic receptor regulation: basic science and clinical implications

21 January 2018

1 reference

Role of the newer alpha, -adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms

21 January 2018

1 reference

Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype

21 January 2018

1 reference

Weight gain associated with the alpha2a-adrenergic receptor -1,291 C/G polymorphism and olanzapine treatment

21 January 2018

1 reference

Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence

21 January 2018

1 reference

Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis

21 January 2018

1 reference

Inhaled beta2-adrenoceptor agonists: cardiovascular safety in patients with obstructive lung disease

21 January 2018

1 reference

Muscarinic receptors: What we know

21 January 2018

1 reference

M<sub>1</sub> Muscarinic Agonists Can Modulate Some of the Hallmarks in Alzheimer's Disease: Implications in Future Therapy

21 January 2018

1 reference

Antimuscarinic agents: implications and concerns in the management of overactive bladder in the elderly

21 January 2018

1 reference

Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder

21 January 2018

1 reference

Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle

21 January 2018

1 reference

Molecular, pharmacological and functional diversity of 5-HT receptors

21 January 2018

1 reference

Drug-induced serotonin syndrome: a review.

21 January 2018

1 reference

Drugs and valvular heart disease

21 January 2018

1 reference

Fibrotic heart-valve reactions to dopamine-agonist treatment in Parkinson's disease

21 January 2018

1 reference

Valvular heart disease and the use of dopamine agonists for Parkinson's disease

21 January 2018

1 reference

Dopamine agonists and the risk of cardiac-valve regurgitation

21 January 2018

1 reference

Severe multivalvular heart disease: a new complication of the ergot derivative dopamine agonists

21 January 2018

1 reference

Lisuride, a Dopamine Receptor Agonist With 5-HT2B Receptor Antagonist Properties

21 January 2018

1 reference

Clozapine-induced weight gain associated with the 5HT2C receptor -759C/T polymorphism

21 January 2018

1 reference

Use of cryopreserved cells for enabling greater flexibility in compound profiling.

21 January 2018

1 reference

Therapeutic and adverse actions of serotonin transporter substrates

21 January 2018

1 reference

The Seattle Heart Failure Model: prediction of survival in heart failure

21 January 2018

1 reference

The dopamine transporter: role in neurotoxicity and human disease

21 January 2018

1 reference

Regulation of dopamine transporter function and plasma membrane expression by dopamine, amphetamine, and cocaine

21 January 2018

1 reference

Keynote review: phosphodiesterase-4 as a therapeutic target

21 January 2018

1 reference

PDE4 inhibitors: current status

21 January 2018

1 reference

Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease

21 January 2018

1 reference

Myocardial phosphodiesterases and regulation of cardiac contractility in health and cardiac disease.

21 January 2018

1 reference

Clinical applications of MAO-inhibitors

21 January 2018

1 reference

3-[5-(4,5-dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor

21 January 2018

1 reference

Therapeutic applications of selective and non-selective inhibitors of monoamine oxidase A and B that do not cause significant tyramine potentiation

21 January 2018

1 reference

A bioluminescent assay for monoamine oxidase activity

21 January 2018

1 reference

GABA(A) receptor subtypes as targets for neuropsychiatric drug development

21 January 2018

1 reference

Gaboxadol -- a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing

21 January 2018

1 reference

The NMDA receptor/ion channel complex: a drug target for modulating synaptic plasticity and excitotoxicity

21 January 2018

1 reference

The chemical biology of clinically tolerated NMDA receptor antagonists

21 January 2018

1 reference

PCP: from pharmacology to modelling schizophrenia

21 January 2018

1 reference

Inducible expression and pharmacological characterization of recombinant rat NR1a/NR2A NMDA receptors.

21 January 2018

1 reference

Understanding mechanisms of toxicity: insights from drug discovery research

21 January 2018

1 reference

Modeling promiscuity based on in vitro safety pharmacology profiling data

21 January 2018

1 reference

Physiochemical drug properties associated with in vivo toxicological outcomes

21 January 2018

1 reference

Cellular dielectric spectroscopy: a label-free comprehensive platform for functional evaluation of endogenous receptors

21 January 2018

1 reference

New cell models and assays in cardiac safety profiling

21 January 2018

1 reference

Embryonic stem cells as a source of models for drug discovery.

21 January 2018

1 reference

Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery.

21 January 2018

1 reference

Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/FMC.09.51

1 reference

release_iw3qftupcvgvjodstcb5rp42ty

24 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/iw3qftupcvgvjodstcb5rp42ty

mapped directly with Wikidata item

24 November 2022

based on heuristic

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