(Q36909315)

17 August 2017

1 reference

title

New cell models and assays in cardiac safety profiling (English)

1 reference

17 August 2017

Thomas Meyer

1

1 reference

17 August 2017

Peter Sartipy

2

1 reference

17 August 2017

Franziska Blind

3

1 reference

17 August 2017

Christine Leisgen

4

1 reference

17 August 2017

Elke Guenther

5

1 reference

17 August 2017

language of work or name

English

0 references

publication date

1 August 2007

1 reference

Expert Opinion on Drug Metabolism & Toxicology

17 August 2017

1 reference

17 August 2017

3

1 reference

17 August 2017

4

1 reference

17 August 2017

507-517

1 reference

Cisapride. Drug interactions of clinical significance

17 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Cisapride-induced long QT interval

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Torsade de pointes induced by terfenadine in a patient with long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

QTc prolongation due to propranolol overdose

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Antipsychotic-related QTc prolongation, torsade de pointes and sudden death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

A high-performance elastomeric patch clamp chip

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Automated electrophysiology: high throughput of art.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Whole cell patch clamp recording performed on a planar glass chip

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Epicardial activation of left ventricular wall prolongs QT interval and transmural dispersion of repolarization: implications for biventricular pacing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: influence of multi-channel block

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Evaluation of functional and binding assays in cells expressing either recombinant or endogenous hERG channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Evaluation of a high-throughput fluorescence assay method for HERG potassium channel inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Sudden cardiac death in patients with chagas heart disease and preserved left ventricular function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Impairment of human ether-à-go-go-related gene (HERG) K+ channel function by hypoglycemia and hyperglycemia. Similar phenotypes but different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

QPatch: the past, present and future of automated patch clamp

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Population patch clamp improves data consistency and success rates in the measurement of ionic currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

The extracellular patch clamp: A method for resolving currents through individual open channels in biological membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Patch Clamp Techniques for Studying Ionic Channels in Excitable Membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

QT interval: a measure of drug action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Terfenadine. A review of its pharmacodynamic properties and therapeutic efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-à-go-go-Related Gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Thorough QT/QTc not so thorough: removes torsadogenic predictors from the T-wave, incriminates safe drugs, and misses profibrillatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Multilineage potential of adult human mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

New potential for human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

In vitro development of primitive and definitive erythrocytes from different precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Effects of electrical fields on cardiomyocyte differentiation of embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Efficient cardiomyocyte differentiation of embryonic stem cells by bone morphogenetic protein-2 combined with visceral endoderm-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Muscle cell differentiation of embryonic stem cells reflects myogenesis in vivo: developmentally regulated expression of myogenic determination genes and functional expression of ionic currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Estimation of action potential changes from field potential recordings in multicellular mouse cardiac myocyte cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Determination of electrical properties of ES cell-derived cardiomyocytes using MEAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Safety of non-antiarrhythmic drugs that prolong the QT interval or induce torsade de pointes: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Ventricular slices of adult mouse hearts--a new multicellular in vitro model for electrophysiological studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Establishment and characterization of a mouse embryonic heart slice preparation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Cardiac repolarization. The long and short of it.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Cellular basis for QT dispersion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

QT-screen: high-throughput cardiac safety pharmacology by extracellular electrophysiology on primary cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Biological application of microelectrode arrays in drug discovery and basic research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Pause induced early afterdepolarizations in the long QT syndrome: a simulation study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

IKr channel blockers: novel antiarrhythmic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Experimental models of torsade de pointes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Drug-induced QT dispersion: does it predict the risk of torsade de pointes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Block of IKs, the slow component of the delayed rectifier K+ current, by the diuretic agent indapamide in guinea pig myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Nonclinical proarrhythmia models: predicting Torsades de Pointes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

Drug‐induced QT interval prolongation: regulatory perspectives and drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.507

21 January 2018

Identifiers

DOI

10.1517/17425255.3.4.507

1 reference

17 August 2017

1 reference