(Q37865527)

24 August 2017

1 reference

title

Role of epigenetic events in chemical carcinogenesis--a justification for incorporating epigenetic evaluations in cancer risk assessment (English)

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24 August 2017

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Frederick A Beland

2

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author name string

Igor Koturbash

series ordinal

1

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PubMed ID

21495867

24 August 2017

Igor P Pogribny

series ordinal

3

1 reference

24 August 2017

1 May 2011

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Toxicology Mechanisms and Methods

24 August 2017

1 reference

24 August 2017

21

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24 August 2017

4

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24 August 2017

289-297

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Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium

24 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Assessment of the uptake and mutagenicity of nickel chloride in salmonella tester strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C mutations are associated with DNA hypomethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

DNA hypermethylation of promoter of gene p53 and p16 in arsenic-exposed people with and without malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

DNA hypomethylation leads to elevated mutation rates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

DNA hypomethylation in cancer: epigenetic scars of a neoplastic journey

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Cancers of the Lung and Nasal Sinuses in Nickel Workers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

DNA hypomethylation in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

21 January 2018

Epigenetics in cancer

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Leukemia risk associated with low-level benzene exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Inhibition of core histones acetylation by carcinogenic nickel(II)

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Attenuation of G1 checkpoint function by the non-genotoxic carcinogen phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Reactive oxygen-induced carcinogenesis causes hypermethylation of p16(Ink4a) and activation of MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Epigenetic changes in cancer as potential targets for prophylaxis and maintenance therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Benzene and lymphohematopoietic malignancies in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Breast cancer epigenetics: normal human mammary epithelial cells as a model system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

The less harmful cigarette: a controversial issue. a tribute to Ernst L. Wynder

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Functional consequences of histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

The epigenomics of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Rethinking how DNA methylation patterns are maintained

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Truncation, deamidation, and oxidation of histone H2B in cells cultured with nickel(II).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Aberrant methylation of the FHIT gene in chronic smokers with early stage squamous cell carcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Metal mutagenesis in transgenic Chinese hamster cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

The reduced expression and aberrant methylation of p16(INK4a) in chromate workers with lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

The effect of phenobarbital on the methylation level of the p16 promoter region in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Chromatin modifications and their function

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Epigenetics and chemical safety assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Histone modification patterns and epigenetic codes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Advances in chemical carcinogenesis: a historical review and prospective

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Carcinogenic effect of nickel compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

A possible role in chemical carcinogenesis for epigenetic, heritable changes in gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Carcinogen exposure and gene promoter hypermethylation in bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Connections between epigenetic gene silencing and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Epigenetic gene silencing in cancer initiation and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Aromatic amines in experimental cancer research: tissue-specific effects, an old problem and new solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

The role of nongenotoxic mechanisms in arylamine carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Chromium genotoxicity: A double-edged sword

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Mammalian cytosine methylation at a glance.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Identification of genes that may play critical roles in phenobarbital (PB)-induced liver tumorigenesis due to altered DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Epigenetic processes and cancer risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

The global smoking epidemic: a history and status report

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Alterations in the methylation status and expression of the raf oncogene in phenobarbital-induced and spontaneous B6C3F1 mouse liver tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

DNA methylation and chromatin - unraveling the tangled web.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Large-scale structure of genomic methylation patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

The role of histone deacetylases (HDACs) in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Review of epidemiologic evidence on benzene and lymphatic and hematopoietic cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

21 January 2018

Epigenetics in cancer

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Patterns of methylation of the c-myc gene in human colorectal cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Reduced expression of the Rassf1a gene and its aberrant DNA methylation in pancreatic duct adenocarcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

The enemy at the gates? DNA adducts as biomarkers of exposure to exogenous and endogenous genotoxic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Mechanisms of nongenotoxic carcinogenesis and assessment of the human hazard.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Benzene exposure and risk of non-Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Potential role of free radicals in benzene-induced myelotoxicity and leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Gene-environment interaction in tobacco-related cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Perturbations of the Ink4a/Arf gene locus in aflatoxin B1-induced mouse lung tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Effect of trichloroethylene on DNA methylation and expression of early-intermediate protooncogenes in the liver of B6C3F1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Effect of trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-Jun and c-Myc protooncogenes in mouse liver: prevention by methionine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

The cancer epigenome--components and functional correlates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Expression and DNA methylation patterns of Tslc1 and Dal-1 genes in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Cancer genes and the pathways they control

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Smoking and lung cancer: the role of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Effects of phenobarbital on DNA methylation in GC-rich regions of hepatic DNA from mice that exhibit different levels of susceptibility to liver tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Environmental exposure measurement in cancer epidemiology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Aryl hydrocarbon receptor mediates benzene-induced hematotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

The International Epidemiology of Lung Cancer: geographical distribution and secular trends.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

The nature of chromosomal aberrations detected in humans exposed to benzene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Systems biology of human benzene exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Effects of nickel, chromate, and arsenite on histone 3 lysine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Arsenite alters global histone H3 methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

The role of epigenetics in environmental and occupational carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

Changes in DNA Methylation Patterns in Subjects Exposed to Low-Dose Benzene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F15376516.2011.557881

10.3109/15376516.2011.557881

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21495867