(Q37879144)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21609190%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

review article

1 reference

title

Bioactivation of herbal constituents: simple alerts in the complex system (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21609190%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21609190%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

author name string

Zhong-Ze Fang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21609190%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Xiu-Li Wang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21609190%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Yun-Feng Cao

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21609190%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Hong Huo

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21609190%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Ling Yang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21609190%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

language of work or name

English

0 references

publication date

24 May 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21609190%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Drug Metabolism & Toxicology

2 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21609190%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21609190%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21609190%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

page(s)

989-1007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21609190%20AND%20SRC:MED&resulttype=core&format=json

Drug interactions between herbal and prescription medicines.

2 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

21 January 2018

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The severity of toxic reactions to ephedra: comparisons to other botanical products and national trends from 1993-2002.

21 January 2018

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Health risks of herbal remedies: an update

21 January 2018

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Identification of drugs that interact with herbs in drug development.

21 January 2018

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Cytochrome P450s and other enzymes in drug metabolism and toxicity

21 January 2018

1 reference

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Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Herbal bioactivation: the good, the bad and the ugly

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

A comprehensive listing of bioactivation pathways of organic functional groups

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2011.586335

In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity

21 January 2018

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Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs

21 January 2018

1 reference

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Is "Chinese herbs nephropathy" a prejudicial term?

21 January 2018

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Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2

21 January 2018

1 reference

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Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Aristolochic acid binds covalently to the exocyclic amino group of purine nucleotides in DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Aristolochic acid as a probable human cancer hazard in herbal remedies: a review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Mechanisms of inhibitory and regulatory effects of methylenedioxyphenyl compounds on cytochrome P450-dependent drug oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Human cytochrome p450 enzyme specificity for bioactivation of safrole to the proximate carcinogen 1'-hydroxysafrole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Identification of the main human cytochrome P450 enzymes involved in safrole 1'-hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Evidence that 4-allyl-o-quinones spontaneously rearrange to their more electrophilic quinone methides: potential bioactivation mechanism for the hepatocarcinogen safrole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Abuse of nutmeg (Myristica fragrans Houtt.): studies on the metabolism and the toxicologic detection of its ingredients elemicin, myristicin, and safrole in rat and human urine using gas chromatography/mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Clinically significant CYP2C inhibition by noscapine but not by glucosamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Meta-analysis of the efficacy of the acetonic kava-kava extract WS1490 in patients with non-psychotic anxiety disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Kava kava: examining new reports of toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Kava extracts: safety and risks including rare hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Identification of novel electrophilic metabolites of piper methysticum Forst (Kava).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Inhibition of human cytochrome P450 activities by kava extract and kavalactones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Metabolism of Bergamottin by Cytochromes P450 2B6 and 3A5

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Mechanism-based inactivation of P450 2A6 by furanocoumarins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Reactive intermediates in the oxidation of menthofuran by cytochromes P-450

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Some biochemical and pharmacological properties of an epoxide metabolite of alclofenac

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Human cytochrome p450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Cytochrome P450 mediated bioactivation of methyleugenol to 1'-hydroxymethyleugenol in Fischer 344 rat and human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Bioactivation of tamoxifen by recombinant human cytochrome p450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Pulmonary toxicity and metabolic activation of dauricine in CD-1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Reversible inhibition of three important human liver cytochrome p450 enzymes by tiliroside

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Study on the mutagenic activity of 13 bioflavonoids with the Salmonella Ara test.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Quenching of quercetin quinone/quinone methides by different thiolate scavengers: stability and reversibility of conjugate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

A safety assessment of coumarin taking into account species-specificity of toxicokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Hepatotoxic pyrrolizidine alkaloids in the Mexican medicinal plant Packera candidissima (Asteraceae: Senecioneae).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Pyrrolizidine alkaloids--genotoxicity, metabolism enzymes, metabolic activation, and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Workshop overview: Hepatotoxicity assessment for botanical dietary supplements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1'-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Investigation of the role of the 2',3'-epoxidation pathway in the bioactivation and genotoxicity of dietary allylbenzene analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Glucuronidation of 1'-hydroxyestragole (1'-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Use of physiologically based biokinetic (PBBK) modeling to study estragole bioactivation and detoxification in humans as compared with male rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Dietary flavonoids: effects on xenobiotic and carcinogen metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Drug-induced liver injury: insights from genetic studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Evaluation of human interindividual variation in bioactivation of estragole using physiologically based biokinetic modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

In silico methods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole: implications for risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Determination of propofol UDP-glucuronosyltransferase (UGT) activities in hepatic microsomes from different species by UFLC–ESI-MS

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Tandem mass spectrometry analysis of N2-(trans-Isoestragol-3'-yl)-2'-deoxyguanosine as a strategy to study species differences in sulfotransferase conversion of the proximate carcinogen 1'-hydroxyestragole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Species differences in the hepatic microsomal enzyme metabolism of the pyrrolizidine alkaloids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Glucuronidation, a new metabolic pathway for pyrrolizidine alkaloids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Herbal interactions on absorption of drugs: Mechanisms of action and clinical risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Membrane transporters in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Effects of dietary chemopreventive phytochemicals on P-glycoprotein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

The gastrointestinal microbiota as a site for the biotransformation of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Small chemicals, bioactivation, and the immune system--a fragile balance of i-tox and benefits?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.586335

Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes

21 January 2018

1 reference

9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/HEP.510240134

Identifiers

DOI

10.1517/17425255.2011.586335

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21609190%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference