(Q37883000)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21629180%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

review article

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title

Locked and unlocked nucleosides in functional nucleic acids (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21629180%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21629180%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

author name string

Holger Doessing

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21629180%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

language of work or name

English

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publication date

27 May 2011

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21629180%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21629180%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

volume

16

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21629180%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

issue

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21629180%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

page(s)

4511-4526

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21629180%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

2 February 2020

copyright license

start time

27 May 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

A route to 2',5'-oligoadenylates with increased stability towards phosphodiesterases.

1 reference

12 December 2020

Construction and selection of bead-bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries designed for rapid PCR-based sequencing

1 reference

12 December 2020

1 reference

12 December 2020

Effect of locked-nucleic acid on a biologically active g-quadruplex. A structure-activity relationship of the thrombin aptamer

1 reference

12 December 2020

A small metalloribozyme with a two-step mechanism

1 reference

12 December 2020

Convergent evolution to an aptamer observed in small populations on DNA microarrays

1 reference

12 December 2020

Locked nucleic acid molecular beacons

1 reference

12 December 2020

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

1 reference

12 December 2020

Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth

1 reference

12 December 2020

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

1 reference

12 December 2020

Nonequilibrium capillary electrophoresis of equilibrium mixtures: a universal tool for development of aptamers.

1 reference

12 December 2020

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

1 reference

12 December 2020

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

1 reference

12 December 2020

Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides

1 reference

12 December 2020

Design of antisense oligonucleotides stabilized by locked nucleic acids

1 reference

12 December 2020

Splice-switching efficiency and specificity for oligonucleotides with locked nucleic acid monomers

1 reference

12 December 2020

NMR Studies of Fully Modified Locked Nucleic Acid (LNA) Hybrids: Solution Structure of an LNA:RNA Hybrid and Characterization of an LNA:DNA Hybrid

1 reference

12 December 2020

In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides

1 reference

12 December 2020

Design of efficient DNAzymes against muscle AChR alpha-subunit cRNA in vitro and in HEK 293 cells.

1 reference

12 December 2020

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

1 reference

12 December 2020

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

1 reference

12 December 2020

Capillary electrophoresis-SELEX selection of aptamers with affinity for HIV-1 reverse transcriptase

1 reference

12 December 2020

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

1 reference

12 December 2020

Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo.

1 reference

12 December 2020

Improved RNA cleavage by LNAzyme derivatives of DNAzymes

1 reference

12 December 2020

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

1 reference

12 December 2020

A novel thrombin binding aptamer containing a G-LNA residue

1 reference

12 December 2020

Selection of aptamers for molecular recognition and characterization of cancer cells

1 reference

12 December 2020

Aptamers as a model for functional evaluation of LNA and 2'-amino LNA.

1 reference

12 December 2020

In vitro selection of functional nucleic acids

1 reference

12 December 2020

The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer

1 reference

12 December 2020

LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1.

1 reference

12 December 2020

In vitro selection identifies key determinants for loop-loop interactions: RNA aptamers selective for the TAR RNA element of HIV-1.

1 reference

12 December 2020

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

1 reference

12 December 2020

In vitro selection of aptamers with affinity for neuropeptide Y using capillary electrophoresis

1 reference

12 December 2020

A simplified and efficient route to 2'-O, 4'-C-methylene-linked bicyclic ribonucleosides (locked nucleic acid).

1 reference

12 December 2020

A general purpose RNA-cleaving DNA enzyme

1 reference

12 December 2020

Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver

1 reference

12 December 2020

A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia

1 reference

12 December 2020

Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites

1 reference

12 December 2020

Efficient and persistent splice switching by systemically delivered LNA oligonucleotides in mice

1 reference

12 December 2020

Aptamer evolution for array-based diagnostics

1 reference

12 December 2020

Application of locked nucleic acids to improve aptamer in vivo stability and targeting function

1 reference

12 December 2020

Selection of smart aptamers by equilibrium capillary electrophoresis of equilibrium mixtures (ECEEM).

1 reference

12 December 2020

Systematic analysis of enzymatic DNA polymerization using oligo-DNA templates and triphosphate analogs involving 2',4'-bridged nucleosides

1 reference

12 December 2020

Label free optical sensor for Avidin based on single gold nanoparticles functionalized with aptamers

1 reference

12 December 2020

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

1 reference

12 December 2020

UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability.

1 reference

12 December 2020

Evaluation of LNA-modified DNAzymes targeting a single nucleotide polymorphism in the large subunit of RNA polymerase II.

1 reference

12 December 2020

SELEX with modified nucleotides

1 reference

12 December 2020

Design and characterization of decoy oligonucleotides containing locked nucleic acids

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12 December 2020

Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution

1 reference

12 December 2020

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

1 reference

12 December 2020

Aptamer directly evolved from live cells recognizes membrane bound immunoglobin heavy mu chain in Burkitt's lymphoma cells.

1 reference

12 December 2020

Non-SELEX: selection of aptamers without intermediate amplification of candidate oligonucleotides

1 reference

12 December 2020

Highly active low magnesium hammerhead ribozyme.

1 reference

12 December 2020

Locked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targets

1 reference

12 December 2020

Applications of aptamers as sensors

1 reference

12 December 2020

Synthesis and properties of 2′-O,4′-C-Ethylene-Bridged nucleic acids (ENA) as effective antisense oligonucleotides

1 reference

12 December 2020

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

1 reference

12 December 2020

Locked nucleic acid aptamers

1 reference

12 December 2020

Conformationally restricted nucleotides as a probe of structure-function relationships in RNA.

1 reference

12 December 2020

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

1 reference

12 December 2020

Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA.

1 reference

12 December 2020

Comparison of nine different real-time PCR chemistries for qualitative and quantitative applications in GMO detection.

1 reference

12 December 2020

Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates

1 reference

12 December 2020

Properties of an in vitro selected Pb2+ cleavage motif

1 reference

12 December 2020

In Vitro Incorporation of LNA Nucleotides

1 reference

12 December 2020

In vitro selection of high-affinity DNA ligands for human IgE using capillary electrophoresis

1 reference

12 December 2020

Gaining target access for deoxyribozymes.

1 reference

12 December 2020

LNA 5'-phosphoramidites for 5'→3'-oligonucleotide synthesis

1 reference

12 December 2020

RNA cleaving '10-23' DNAzymes with enhanced stability and activity

1 reference

12 December 2020

In vitro evolution of functional DNA using capillary electrophoresis

1 reference

12 December 2020

Selection of hammerhead ribozyme variants with low Mg2+ requirement: importance of stem-loop II.

1 reference

12 December 2020

The utility of LNA in microRNA-based cancer diagnostics and therapeutics

1 reference

12 December 2020

Oligonucleotide inhibitors of human thrombin that bind distinct epitopes

1 reference

12 December 2020

Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing

1 reference

12 December 2020

The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.

1 reference

12 December 2020

The conformations of locked nucleic acids (LNA)

1 reference

12 December 2020

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.

1 reference

12 December 2020

In vitro splicing of the ribosomal RNA precursor in nuclei of Tetrahymena

1 reference

12 December 2020

Database of non-canonical base pairs found in known RNA structures

1 reference

12 December 2020

Reconciliation of the X-ray and NMR structures of the thrombin-binding aptamer d(GGTTGGTGTGGTTGG).

1 reference

12 December 2020

Novel Applications of Locked Nucleic Acids

1 reference

12 December 2020

SELEX--a (r)evolutionary method to generate high-affinity nucleic acid ligands

1 reference

12 December 2020

Synthesis and evaluation of oligodeoxynucleotides containing acyclic nucleosides: Introduction of three novel analogues and a summary

1 reference

12 December 2020

LNA-antisense rivals siRNA for gene silencing

1 reference

12 December 2020

Monitoring HCV RNA viral load by locked nucleic acid molecular beacons real time PCR.

1 reference

12 December 2020

Optimization and modifications of aptamers selected from live cancer cell lines.

1 reference

12 December 2020

Catalytic DNAzymes: derivations and functions

1 reference

12 December 2020

Stitching together RNA tertiary architectures

1 reference

12 December 2020

Unlocked nucleic acid--an RNA modification with broad potential.

1 reference

12 December 2020

Systematic screening of LNA/2'-O-methyl chimeric derivatives of a TAR RNA aptamer

1 reference

12 December 2020

Non-SELEX selection of aptamers

1 reference

12 December 2020

Unlocked nucleic acid (UNA) and UNA derivatives: thermal denaturation studies

1 reference

12 December 2020

LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA.

1 reference

12 December 2020

Effect of 3'-end capping of aptamer with various 2',4'-bridged nucleotides: Enzymatic post-modification toward a practical use of polyclonal aptamers

1 reference

12 December 2020

Enzymatic incorporation of LNA nucleotides into DNA strands.

1 reference

12 December 2020

Aptamers come of age - at last

1 reference

12 December 2020

Exploring the sequence space of a DNA aptamer using microarrays

1 reference

12 December 2020

The therapeutic potential of LNA-modified siRNAs: reduction of off-target effects by chemical modification of the siRNA sequence

1 reference

12 December 2020

An Endogenous TNF-α Antagonist Induced by Splice-switching Oligonucleotides Reduces Inflammation in Hepatitis and Arthritis Mouse Models

1 reference

12 December 2020

“Locked onto the target”: increasing the efficiency of antagomirzymes using locked nucleic acid modifications

1 reference

12 December 2020

LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage.

1 reference

12 December 2020

Tenascin-C aptamers are generated using tumor cells and purified protein

1 reference

12 December 2020

The advantages of being locked. Assessing the cleavage of short and long RNAs by locked nucleic acid-containing 8-17 deoxyribozymes.

1 reference

12 December 2020

Locked nucleic acid based beacons for surface interaction studies and biosensor development

1 reference

12 December 2020

Structural studies of LNA:RNA duplexes by NMR: conformations and implications for RNase H activity

1 reference

12 December 2020

LNA nucleotides improve cleavage efficiency of singular and binary hammerhead ribozymes

1 reference

12 December 2020

Efficient enzymatic synthesis of LNA-modified DNA duplexes using KOD DNA polymerase

1 reference

12 December 2020

In vitro selection of RNA molecules that bind specific ligands

1 reference

12 December 2020

10-23 DNAzyme modified with (2'R)- and (2'S)-2'-deoxy-2'-C-methyluridine in the catalytic core

1 reference

12 December 2020

10.3390/MOLECULES16064511

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21629180%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21629180%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

21629180

1 reference