(Q37883974)

24 August 2017

1 reference

title

Bim: guardian of tissue homeostasis and critical regulator of the immune system, tumorigenesis and bone biology (English)

1 reference

24 August 2017

1 reference

Toru Akiyama

1

1 reference

PubMed ID

21633919

24 August 2017

Sakae Tanaka

series ordinal

2

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24 August 2017

3 June 2011

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Archivum Immunologiae et Therapiae Experimentalis

24 August 2017

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24 August 2017

59

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24 August 2017

4

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24 August 2017

277-287

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https://scigraph.springernature.com/pub.10.1007/s00005-011-0126-1

24 August 2017

0 references

cites work

Nomenclature of dynein light chain-linked BH3-only protein Bim isoforms.

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone-resorbing activity, and apoptosis pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Bim-targeted cancer therapy: a link between drug action and underlying molecular changes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

How death shapes life during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Dicer is essential for mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Mutant B-RAF mediates resistance to anoikis via Bad and Bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

CD95, BIM and T cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Bim expression is reduced in human cutaneous melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Cell death: critical control points

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Regulation of bim in glucocorticoid-mediated osteoblast apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

BH3-only proteins and their roles in programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Active N-Ras and B-Raf inhibit anoikis by downregulating Bim expression in melanocytic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

The biochemistry of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Immortalization of osteoclast precursors by targeting Bcl -XL and Simian virus 40 large T antigen to the osteoclast lineage in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Osteoblast apoptosis and bone turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Transforming growth factor-beta1 (TGF-beta1) induces human osteoclast apoptosis by up-regulating Bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Multisite phosphorylation regulates Bim stability and apoptotic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Akt1 in osteoblasts and osteoclasts controls bone remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Activation of the JNK pathway promotes phosphorylation and degradation of BimEL--a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Causal relationship between the loss of RUNX3 expression and gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

BH3-only proteins in apoptosis and beyond: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Role of Bim in the survival pathway induced by Raf in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Lucifer's labyrinth--ten years of path finding in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Bim: a novel member of the Bcl-2 family that promotes apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Taxanes and COX-2 inhibitors: from molecular pathways to clinical practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

ER stress triggers apoptosis by activating BH3-only protein Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Anoikis resistance and tumor metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Prognostic impact of bim, puma, and noxa expression in human colon carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

The role of BH3-only proteins in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Essential and overlapping functions for mammalian Argonautes in microRNA silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Signaling axis in osteoclast biology and therapeutic targeting in the RANKL/RANK/OPG system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Mesothelin promotes anchorage-independent growth and prevents anoikis via extracellular signal-regulated kinase signaling pathway in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Posttranslational regulation of Bim by caspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Negative feedback loop in the Bim-caspase-3 axis regulating apoptosis and activity of osteoclasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

c-Cbl is not required for ERK1/2-dependent degradation of BimEL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

RACK1 and CIS mediate the degradation of BimEL in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-011-0126-1

10.1007/S00005-011-0126-1

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21633919