(Q37885729)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21647200%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

review article

1 reference

title

Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21647200%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

0 references

0 references

1 reference

2

1 reference

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3 February 2020

Thorarinn Gudjonsson

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21647200%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Ole Haagen Nielsen

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21647200%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Jakob Benedict Seidelin

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21647200%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

author name string

Sigrun Thorsteinsdottir

1

1 reference

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3 February 2020

Ben Vainer

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21647200%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

language of work or name

English

0 references

publication date

7 June 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21647200%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Gastroenterology & Hepatology

3 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21647200%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21647200%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21647200%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

page(s)

395-404

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21647200%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrgastro.2011.96

3 February 2020

exact match

0 references

cites work

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The risk of colorectal cancer in ulcerative colitis: a meta-analysis

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Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications.

21 January 2018

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Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation

21 January 2018

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Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis.

21 January 2018

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Inflammatory bowel disease

21 January 2018

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Toll-like receptors in inflammatory bowel diseases: a decade later

21 January 2018

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NOX enzymes and Toll-like receptor signaling.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Oxidative stress in ulcerative colitis-associated carcinogenesis

21 January 2018

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The contribution of endogenous sources of DNA damage to the multiple mutations in cancer

21 January 2018

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Oxidants and free radicals in inflammatory bowel disease

21 January 2018

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Nitrative DNA damage in inflammation and its possible role in carcinogenesis

21 January 2018

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Quantitation of 8-Oxoguanine and Strand Breaks Produced by Four Oxidizing Agents

21 January 2018

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Peroxynitrite-induced mutation spectra of pSP189 following replication in bacteria and in human cells

21 January 2018

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Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants

21 January 2018

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Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Continuous cytokine exposure of colonic epithelial cells induces DNA damage.

21 January 2018

1 reference

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Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis

21 January 2018

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Radical causes of cancer.

21 January 2018

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Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation

21 January 2018

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Decreased total and corrected antioxidant capacity in patients with inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

The signaling mechanism of ROS in tumor progression

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

The role of reactive oxygen species in integrin and matrix metalloproteinase expression and function

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Consensus conference: Colorectal cancer screening and surveillance in inflammatory bowel disease

21 January 2018

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Cancer surveillance in ulcerative colitis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Limits of diagnosis and molecular markers for early detection of ulcerative colitis-associated colorectal neoplasia

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

APC mutations occur early during colorectal tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Comparative analysis of histology, DNA content, p53 and Ki-ras mutations in colectomy specimens with long-standing ulcerative colitis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Chromosomal alterations in ulcerative colitis-related neoplastic progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Chromosomal alterations in ulcerative colitis-related and sporadic colorectal cancers by comparative genomic hybridization

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

DNA fingerprinting abnormalities can distinguish ulcerative colitis patients with dysplasia and cancer from those who are dysplasia/cancer-free

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Genomic biomarkers to improve ulcerative colitis neoplasia surveillance.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Sensing and repairing DNA double-strand breaks

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

H2AX: functional roles and potential applications

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

H2AX: the histone guardian of the genome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Mechanisms of eukaryotic DNA double strand break repair

21 January 2018

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

21 January 2018

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Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway

21 January 2018

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Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents

21 January 2018

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Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation.

21 January 2018

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Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage.

21 January 2018

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Chromosomal instability in ulcerative colitis is related to telomere shortening

21 January 2018

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Oxidative stress shortens telomeres

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

A DNA damage checkpoint response in telomere-initiated senescence

21 January 2018

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The signals and pathways activating cellular senescence

21 January 2018

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The power and the promise of oncogene-induced senescence markers.

21 January 2018

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The senescence-associated secretory phenotype: the dark side of tumor suppression

21 January 2018

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Effects on sister chromatid exchange frequency of aldehyde dehydrogenase 2 genotype and smoking in vinyl chloride workers.

21 January 2018

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8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis

21 January 2018

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8-Hydroxyguanine (7,8-dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene: effects of sequence contexts on mutation spectra

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Repair and replication of plasmids with site-specific 8-oxodG and 8-AAFdG residues in normal and repair-deficient human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Oxidative DNA damage in the mucosa of ulcerative colitis increases with disease duration and dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Altered expression of MUTYH and an increase in 8-hydroxydeoxyguanosine are early events in ulcerative colitis-associated carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Measurement of DNA oxidation in human cells by chromatographic and enzymic methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Comparative analysis of baseline 8-oxo-7,8-dihydroguanine in mammalian cell DNA, by different methods in different laboratories: an approach to consensus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Comparison of the levels of 8-hydroxyguanine in DNA as measured by gas chromatography mass spectrometry following hydrolysis of DNA by Escherichia coli Fpg protein or formic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Cancer surveillance in inflammatory bowel disease: new molecular approaches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

DNA aneuploidy in ulcerative colitis and in colorectal carcinoma--a comparative study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Microsatellite instability in cancer of the proximal colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Microsatellite instability in long-standing ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Clinical significance of microsatellite instability in the inflamed mucosa for the prediction of colonic neoplasms in patients with ulcerative colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Racemization of aspartic acid in human proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Abundant expression of AMACR in many distinct tumour types

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

PSA and beyond: the past, present, and future of investigative biomarkers for prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

AMACR immunostaining is useful in detecting dysplastic epithelium in Barrett's esophagus, ulcerative colitis, and Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Ki-67: a useful marker for the evaluation of dysplasia in ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Immunohistochemical assessment of Ki67 and p53 expression assists the diagnosis and grading of ulcerative colitis-related dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Accumulation of lipid peroxidation-derived DNA lesions: potential lead markers for chemoprevention of inflammation-driven malignancies

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Increased etheno-DNA adducts in affected tissues of patients suffering from Crohn's disease, ulcerative colitis, and chronic pancreatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

5-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Drug insight: aminosalicylates for the treatment of IBD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

On the antioxidant properties of therapeutic drugs: quenching of singlet molecular oxygen by aminosalicylic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Antioxidant effects of aminosalicylates and potential new drugs for inflammatory bowel disease: assessment in cell-free systems and inflamed human colorectal biopsies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Cyclooxygenase-2-dependent and -independent inhibition of proliferation of colon cancer cells by 5-aminosalicylic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

5-aminosalicylic acid interferes in the cell cycle of colorectal cancer cells and induces cell death modes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Proinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS2 induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Immunomodulatory cytokines suppress epithelial nitric oxide production in inflammatory bowel disease by acting on mononuclear cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis–Associated Neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Tumor Necrosis Factor-α Increases the Steady-state Reduction of Cytochromebof the Mitochondrial Respiratory Chain in Metabolically Inhibited L929 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Survival and cause-specific mortality in ulcerative colitis: follow-up of a population-based cohort in Copenhagen County

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Free radicals and phagocytic cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Nitric oxide-induced deamination of cytosine and guanine in deoxynucleosides and oligonucleotides

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Tyrosine nitration by peroxynitrite formed from nitric oxide and superoxide generated by xanthine oxidase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Peroxynitrite causes DNA damage and oxidation of thiols in rat thymocytes [corrected]

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Oxy radicals, lipid peroxidation and DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Glutathione content of colonic mucosa: evidence for oxidative damage in active ulcerative colitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Observer study of the grading of dysplasia in ulcerative colitis: comparison with clinical outcome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Strategies for detecting colon cancer and/or dysplasia in patients with inflammatory bowel disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

DNA content and mucosal dysplasia in ulcerative colitis. Flow cytometric analysis in patients with dysplastic or indefinite morphologic changes in the colorectal mucosa

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

DNA aneuploidy and histologic dysplasia in long-standing ulcerative colitis. A 10-year follow-up study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

The pattern of cell proliferation in neoplastic and nonneoplastic lesions of ulcerative colitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Clinical evidence supporting the radical scavenger mechanism of 5-aminosalicylic acid

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Inhibition of NF-kappaB by IkappaB prevents cytokine-induced NO production and promotes enterocyte apoptosis in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2011.96

Activation of the p53 tumor suppressor protein

31 March 2020

1 reference

12 December 2020

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer

1 reference

12 December 2020

Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67

1 reference

12 December 2020

In vitro studies on the significance of arachidonate metabolism and other oxidative processes in the inflammatory response of human neutrophils and macrophages. With special reference to chronic inflammatory bowel disease

1 reference

12 December 2020

Usefulness of analysis of p53 alteration and observation of surface microstructure for diagnosis of ulcerative colitis-associated colorectal neoplasia

1 reference

12 December 2020

Excessive production of reactive oxygen metabolites by inflamed colon: Analysis by chemiluminescence probe

1 reference

12 December 2020

Dynamics in the p53-Mdm2 ubiquitination pathway

1 reference

12 December 2020

Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis

1 reference

12 December 2020

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation

1 reference

12 December 2020

Microsatellite instability occurs frequently in human gastric carcinoma

1 reference

12 December 2020

Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease

1 reference

12 December 2020

Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis

1 reference

12 December 2020

Evaluation of the usefulness of testing for p53 mutations in colorectal cancer surveillance for ulcerative colitis

1 reference

12 December 2020

Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1

1 reference

12 December 2020

DNA aneuploidy in ulcerative colitis: reproducibility, topographic distribution, and relation to dysplasia

1 reference

12 December 2020

Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRGASTRO.2011.96

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21647200%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1 reference