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Activation of the p53 tumor suppressor protein
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
11960694
retrieved
3 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Activation of the p53 tumor suppressor protein
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11960694
retrieved
3 August 2017
author
Karen Vousden
series ordinal
1
object named as
Karen H Vousden
1 reference
stated in
Europe PubMed Central
PubMed ID
11960694
retrieved
3 August 2017
language of work or name
English
0 references
publication date
1 March 2002
1 reference
stated in
Europe PubMed Central
PubMed ID
11960694
retrieved
3 August 2017
number of pages
13
1 reference
based on heuristic
inferred from page(s)
published in
Biochimica et Biophysica Acta
1 reference
stated in
Europe PubMed Central
PubMed ID
11960694
retrieved
3 August 2017
volume
1602
1 reference
stated in
Europe PubMed Central
PubMed ID
11960694
retrieved
3 August 2017
page(s)
47-59
1 reference
stated in
Europe PubMed Central
PubMed ID
11960694
retrieved
3 August 2017
issue
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11960694
retrieved
3 August 2017
cites work
p53 mutations in human cancers
1 reference
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Crossref
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7 January 2021
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Achilles' heel of cancer?
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p53: death star
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reference URL
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7 January 2021
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Post-translational modifications and activation of p53 by genotoxic stresses
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 stability by Mdm2
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
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inferred from DOI database lookup
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
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MdmX protects p53 from Mdm2-mediated degradation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
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Amplification of a gene encoding a p53-associated protein in human sarcomas
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of ubiquitination and degradation of p53 in unstressed cells through C-terminal phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
No requirement for src family kinases for PDGF signaling in fibroblasts expressing SV40 large T antigen
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Control of cell cycle progression by c-Jun is p53 dependent
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AP-1 repressor protein JDP-2: inhibition of UV-mediated apoptosis through p53 down-regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
JunD protects cells from p53-dependent senescence and apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Increase in AP-1 activity is a general event in thyroid cell transformation in vitro and in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement of Ras/MAPK pathway activation by transforming growth factor beta for transforming growth factor beta 1 production in a Smad-dependent pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
p19ARF links the tumour suppressor p53 to Ras
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Transformation by ras modifies AP1 composition and activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
p53 down-regulates CHK1 through p21 and the retinoblastoma protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of murine double minute clone 2 (MDM2) protein at serine-267 by protein kinase CK2 in vitro and in cultured cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin a-CDK phosphorylation regulates MDM2 protein interactions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of p53 by roscovitine-mediated suppression of MDM2 expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 function and stability by phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Downregulation of free ubiquitin: a novel mechanism of p53 stabilization and neuronal cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Mdm-2 amino terminus is required for Mdm2 binding and SUMO-1 conjugation by the E2 SUMO-1 conjugating enzyme Ubc9
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A TPR motif cofactor contributes to p300 activity in the p53 response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ARF/p53 pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53-independent functions of the p19(ARF) tumor suppressor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
JNK targets p53 ubiquitination and degradation in nonstressed cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 is associated with cellular microtubules and is transported to the nucleus by dynein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functions of the MDM2 oncoprotein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MDM2 RING-finger domain is required to promote p53 nuclear export
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
C-terminal ubiquitination of p53 contributes to nuclear export
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ZBP-89 promotes growth arrest through stabilization of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular biology. Getting p53 out of the nucleus.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 mutant defective in binding p300 promotes ubiquitination but not degradation of p53: evidence for the role of p300 in integrating ubiquitination and proteolysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The contribution of the acidic domain of MDM2 to p53 and MDM2 stability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p300/MDM2 complexes participate in MDM2-mediated p53 degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDM2-dependent ubiquitination of nuclear and cytoplasmic P53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of p53 sequence elements that are required for MDM2-mediated nuclear export
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear exclusion of p53 in a subset of tumors requires MDM2 function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The function of PML in p53-dependent apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 activity in nuclear bodies by a specific PML isoform
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Atmospheric carbon dioxide concentrations over the past 60 million years
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
P53 and PML: new partners in tumor suppression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Allosteric activation of latent p53 tetramers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High mobility group protein-1 (HMG-1) is a unique activator of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 Latency. C-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Latent and active p53 are identical in conformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Covalent and noncovalent modifiers of the p53 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the specific DNA binding function of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SUMO-1 modification activates the transcriptional response of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
c-Jun and p53 Activity Is Modulated by SUMO-1 Modification
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional analysis and intracellular localization of p53 modified by SUMO-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage activates p53 through a phosphorylation-acetylation cascade
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deacetylation of p53 modulates its effect on cell growth and apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Histone deacetylases specifically down-regulate p53-dependent gene activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The N terminus of p53 regulates its dissociation from DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of p53 serine 15 increases interaction with CBP
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Osmotic shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proliferation, cell cycle and apoptosis in cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recruitment of p300/CBP in p53-dependent signal pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Binding and modulation of p53 by p300/CBP coactivators
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synergistic activation of transcription by CBP and p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AMF1 (GPS2) modulates p53 transactivation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ASPP proteins specifically stimulate the apoptotic function of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel cofactor for p300 that regulates the p53 response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900035-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0304-419X(02)00035-5
1 reference
stated in
Europe PubMed Central
PubMed ID
11960694
retrieved
3 August 2017
PubMed ID
11960694
1 reference
stated in
Europe PubMed Central
PubMed ID
11960694
retrieved
3 August 2017
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