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An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2
scientific article published on 01 July 2001
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
title
An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
author name string
S C Evans
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
M Viswanathan
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
J D Grier
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3
1 reference
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Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
M Narayana
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
A K El-Naggar
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
G Lozano
series ordinal
6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
language of work or name
English
0 references
publication date
1 July 2001
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
published in
Oncogene
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
volume
20
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
issue
30
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
page(s)
4041-4049
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
exact match
https://scigraph.springernature.com/pub.10.1038/sj.onc.1204533
0 references
cites work
Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mapping of the p53 and mdm-2 interaction domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
WAF1, a potential mediator of p53 tumor suppression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Exclusion of a p53 germline mutation in a classic Li-Fraumeni syndrome family
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 promotes the rapid degradation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 stability by Mdm2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of Mdm2-directed degradation by the C terminus of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A simple salting out procedure for extracting DNA from human nucleated cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MDM2 gene amplification database
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amplification of a gene encoding a p53-associated protein in human sarcomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53-mdm-2 autoregulatory feedback loop
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204533
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.ONC.1204533
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
Dimensions Publication ID
1034225504
0 references
PubMed publication ID
11494132
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11494132
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494132%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
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