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The contribution of the acidic domain of MDM2 to p53 and MDM2 stability
scientific article published on 01 March 2001
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Europe PubMed Central
PubMed publication ID
11313871
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313871%20AND%20SRC:MED&resulttype=core&format=json
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6 November 2019
title
The contribution of the acidic domain of MDM2 to p53 and MDM2 stability
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11313871
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313871%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
author
Bohdan Wasylyk
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11313871
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313871%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
author name string
M Argentini
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1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11313871
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313871%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
N Barboule
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2
1 reference
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Europe PubMed Central
PubMed publication ID
11313871
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313871%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
language of work or name
English
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publication date
1 March 2001
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11313871
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313871%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
published in
Oncogene
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11313871
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313871%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
volume
20
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11313871
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313871%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
issue
11
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11313871
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313871%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
page(s)
1267-1275
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11313871
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313871%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
exact match
https://scigraph.springernature.com/pub.10.1038/sj.onc.1204241
0 references
cites work
The contribution of the RING finger domain of MDM2 to cell cycle progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
mdm2 expression is induced by wild type p53 activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High-efficiency transformation of mammalian cells by plasmid DNA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mapping of the p53 and mdm-2 interaction domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MDM2 oncoprotein binds specifically to RNA through its RING finger domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
JNK targets p53 ubiquitination and degradation in nonstressed cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MDM2 RING-finger domain is required to promote p53 nuclear export
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 in growth control and neoplasia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p300/MDM2 complexes participate in MDM2-mediated p53 degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a sequence element from p53 that signals for Mdm2-targeted degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pathways of ubiquitin conjugation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 promotes the rapid degradation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RB regulates the stability and the apoptotic function of p53 via MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53: puzzle and paradigm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 stability by Mdm2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of Mdm2-directed degradation by the C terminus of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53, the cellular gatekeeper for growth and division
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a cryptic nucleolar-localization signal in MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mouse-human heterokaryon analysis with a 33258 Hoechst-Giemsa technique
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Subpopulations of proteasomes in rat liver nuclei, microsomes and cytosol
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitin biology: an old dog learns an old trick
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intracellular distribution of proteasomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor surveillance via the ARF-p53 pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of the multicatalytic proteinases isolated from the nucleus and cytoplasm of chicken red blood cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Physical association of ubiquitin ligases and the 26S proteasome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and classification of p53-regulated genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204241
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.ONC.1204241
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11313871
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313871%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
Dimensions Publication ID
1022226235
0 references
PubMed publication ID
11313871
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11313871
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313871%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
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