(Q52534736)

2 May 2018

title

p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53. (English)

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2 May 2018

1 reference

C Wasylyk

1

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2 May 2018

R Salvi

2

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2 May 2018

M Argentini

3

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2 May 2018

C Dureuil

4

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2 May 2018

I Delumeau

5

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2 May 2018

J Abecassis

6

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2 May 2018

L Debussche

7

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2 May 2018

B Wasylyk

8

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2 May 2018

language of work or name

English

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publication date

1 March 1999

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2 May 2018

published in

Oncogene

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2 May 2018

volume

18

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2 May 2018

issue

11

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2 May 2018

page(s)

1921-1934

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2 May 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1202528

exact match

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cites work

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mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

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Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage

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CTS1: a p53-derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties

21 January 2018

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

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WAF1, a potential mediator of p53 tumor suppression

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Amplification of MDM2 inhibits MyoD-mediated myogenesis

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The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

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A transcriptionally active DNA-binding site for human p53 protein complexes

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

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The mdm2 proto-oncogene

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Tumor suppressors: a developing role for p53?

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p53; from inductive signal to cellular effect

21 January 2018

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Mdm2 promotes the rapid degradation of p53

21 January 2018

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Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines

21 January 2018

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E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

21 January 2018

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Role of E2F in cell cycle control and cancer

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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Regulation of p53 stability by Mdm2

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

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MDM2--arbiter of p53's destruction

21 January 2018

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p53, the cellular gatekeeper for growth and division

21 January 2018

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The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter

21 January 2018

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MDM2 expression during mouse embryogenesis and the requirement of p53.

21 January 2018

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A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

21 January 2018

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Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

21 January 2018

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The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

21 January 2018

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Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

21 January 2018

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p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

21 January 2018

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Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage

21 January 2018

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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Mdm-2: "big brother" of p53.

21 January 2018

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

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A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

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Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

21 January 2018

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The p53-MDM2 interaction in a cancer-prone family, and the identification of a novel therapeutic target

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

Mdm2: keeping p53 under control

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

Induction of Mdm2 and enhancement of cell survival by bFGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

Functional interaction between DP-1 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

p53 tumor-suppressor gene: clues to molecular carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

p53 and E2F-1 cooperate to mediate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

High prognostic significance of Mdm2/p53 co-overexpression in soft tissue sarcomas of the extremities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

Interaction between the retinoblastoma protein and the oncoprotein MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

A functional p53-responsive intronic promoter is contained within the humanmdm2gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

Involvement of p53 in cell differentiation and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

7 January 2021

Transcription abnormalities potentiate apoptosis of normal human fibroblasts.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

7 January 2021

E2F: a nodal point in cell cycle regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

7 January 2021

The MDM2 oncoprotein binds specifically to RNA through its RING finger domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

7 January 2021

MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

7 January 2021

P53 gene alterations in human tumors: perspectives for cancer control.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

7 January 2021

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

7 January 2021

Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

7 January 2021

p53 and ATM: cell cycle, cell death, and cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

7 January 2021

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

7 January 2021

Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets1 and Pointed P2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

7 January 2021

Teratogen-induced eye defects mediated by p53-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1202528

1 reference

2 May 2018

1 reference

2 May 2018