(Q37888463)

24 August 2017

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title

The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming (English)

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24 August 2017

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C H Eng

1

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24 August 2017

R T Abraham

series ordinal

2

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24 August 2017

language of work or name

English

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publication date

13 June 2011

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24 August 2017

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24 August 2017

volume

30

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24 August 2017

issue

47

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24 August 2017

page(s)

4687-4696

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https://scigraph.springernature.com/pub.10.1038/onc.2011.220

24 August 2017

exact match

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cites work

Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

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Principles and current strategies for targeting autophagy for cancer treatment

21 January 2018

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The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway

21 January 2018

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MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy

21 January 2018

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Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Modulation of intracellular ROS levels by TIGAR controls autophagy

21 January 2018

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

21 January 2018

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Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila

21 January 2018

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Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer

21 January 2018

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

21 January 2018

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Autophagy and tumorigenesis

21 January 2018

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Superoxide is the major reactive oxygen species regulating autophagy

21 January 2018

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GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation.

21 January 2018

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MYC-induced cancer cell energy metabolism and therapeutic opportunities

21 January 2018

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

21 January 2018

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagy, not apoptosis, is essential for midgut cell death in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

21 January 2018

Autophagy in infection

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https://api.crossref.org/works/10.1038%2FONC.2011.220

NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Akt stimulates aerobic glycolysis in cancer cells

21 January 2018

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Glutaminolysis yields a metabolic by-product that stimulates autophagy

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Ammonia derived from glutaminolysis is a diffusible regulator of autophagy

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes.

21 January 2018

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Fuel feeds function: energy metabolism and the T-cell response

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Ras is involved in the negative control of autophagy through the class I PI3-kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts

21 January 2018

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

21 January 2018

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Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway

21 January 2018

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A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases

21 January 2018

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Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

21 January 2018

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A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress.

21 January 2018

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Macroautophagy regulates energy metabolism during effector T cell activation

21 January 2018

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Amino Acids and Insulin Control Autophagic Proteolysis through Different Signaling Pathways in Relation to mTOR in Isolated Rat Hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Lysosomal positioning coordinates cellular nutrient responses.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagic cell death: the story of a misnomer

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.220

Fatty acid synthesis: a potential selective target for antineoplastic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

The association of AMPK with ULK1 regulates autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Induction of autophagy and inhibition of tumorigenesis by beclin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

FoxO3 controls autophagy in skeletal muscle in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagy suppresses tumorigenesis through elimination of p62

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagy suppresses tumor progression by limiting chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

p53 regulates mitochondrial respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Tumor-host interactions: a far-reaching relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Nix is a selective autophagy receptor for mitochondrial clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Glycolysis and methylaminoisobutyrate uptake in rat-1 cells transfected with ras or myc oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagy is required during cycling hypoxia to lower production of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Glutamine increases autophagy under Basal and stressed conditions in intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Essential role for Nix in autophagic maturation of erythroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

HIF-1: upstream and downstream of cancer metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Ras, PI(3)K and mTOR signalling controls tumour cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Mantle skewness and ridge segmentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagy-deficient mice develop multiple liver tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Ras transformation requires metabolic control by 6-phosphofructo-2-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 mice [corrected] fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagy gone awry in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Pancreatic cancers require autophagy for tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagic programmed cell death by selective catalase degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Small molecule regulators of autophagy identified by an image-based high-throughput screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Mammalian target of rapamycin as a therapeutic target in oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagy in Ras-induced malignant transformation: fatal or vital?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

Autophagy regulates lipid metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.220

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.220

1 reference

24 August 2017

1 reference