(Q37894700)

24 August 2017

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title

Target identification and validation of novel antimalarials (English)

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24 August 2017

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Elizabeth A Winzeler

2

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author name string

Case McNamara

series ordinal

1

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24 August 2017

language of work or name

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1 June 2011

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24 August 2017

number of pages

12

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based on heuristic

inferred from page(s)

published in

Future Microbiology

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24 August 2017

volume

6

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24 August 2017

issue

6

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24 August 2017

page(s)

693-704

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Artemisinin Resistance in Plasmodium falciparum Malaria

24 August 2017

cites work

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Evidence of Artemisinin-Resistant Malaria in Western Cambodia

21 January 2018

1 reference

Qinghaosu (Artemisinin): The Price of Success

21 January 2018

1 reference

Artemisinin resistance--the clock is ticking

21 January 2018

1 reference

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

21 January 2018

1 reference

Thousands of chemical starting points for antimalarial lead identification

21 January 2018

1 reference

Chemical genetics of Plasmodium falciparum

21 January 2018

1 reference

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

21 January 2018

1 reference

The molecular mechanism of action of artemisinin--the debate continues.

21 January 2018

1 reference

Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum

21 January 2018

1 reference

The fate of ferriprotorphyrin IX in malaria infected erythrocytes in conjunction with the mode of action of antimalarial drugs

21 January 2018

1 reference

Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria

21 January 2018

1 reference

Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization

21 January 2018

1 reference

Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites

21 January 2018

1 reference

Malaria, Plasmodium falciparum and its apicoplast

21 January 2018

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The evolution, metabolism and functions of the apicoplast

21 January 2018

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The effects of anti-bacterials on the malaria parasite Plasmodium falciparum.

21 January 2018

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Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum

21 January 2018

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Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast

21 January 2018

1 reference

A plastid segregation defect in the protozoan parasite Toxoplasma gondii

21 January 2018

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Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility

21 January 2018

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Global profiling of proteolysis during rupture of Plasmodium falciparum from the host erythrocyte

21 January 2018

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A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes

21 January 2018

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Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

21 January 2018

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Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7.

21 January 2018

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Variations in frequencies of drug resistance in Plasmodium falciparum

21 January 2018

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Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

21 January 2018

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Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site

21 January 2018

1 reference

Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum

21 January 2018

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Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand

21 January 2018

1 reference

A molecular marker for chloroquine-resistant falciparum malaria

21 January 2018

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How can we identify parasite genes that underlie antimalarial drug resistance?

21 January 2018

1 reference

Validation of isoleucine utilization targets in Plasmodium falciparum

21 January 2018

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Spiroindolones, a potent compound class for the treatment of malaria

21 January 2018

1 reference

Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism

21 January 2018

1 reference

Resistance to antimalarial compounds: methods and applications

21 January 2018

1 reference

PlasmoDB: a functional genomic database for malaria parasites

21 January 2018

1 reference

OrthoMCL: Identification of Ortholog Groups for Eukaryotic Genomes

21 January 2018

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PlasmoPredict: a gene function prediction website for Plasmodium falciparum

21 January 2018

1 reference

Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses

21 January 2018

1 reference

Complementation of Saccharomyces cerevisiaepik1ts by a phosphatidylinositol 4-kinase from Plasmodium falciparum

21 January 2018

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Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites

21 January 2018

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A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates

21 January 2018

1 reference

An erythrocyte vesicle protein exported by the malaria parasite promotes tubovesicular lipid import from the host cell surface

21 January 2018

1 reference

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

21 January 2018

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Heterologous expression of plasmodial proteins for structural studies and functional annotation

21 January 2018

1 reference

Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms

21 January 2018

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Adjustment of codon usage frequencies by codon harmonization improves protein expression and folding

21 January 2018

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Heterologous protein expression is enhanced by harmonizing the codon usage frequencies of the target gene with those of the expression host.

21 January 2018

1 reference

Process development and analysis of liver-stage antigen 1, a preerythrocyte-stage protein-based vaccine for Plasmodium falciparum

21 January 2018

1 reference

Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidates

21 January 2018

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Production of recombinant proteins from protozoan parasites

21 January 2018

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The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif

21 January 2018

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Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.

21 January 2018

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Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands

21 January 2018

1 reference

Antifolate screening using yeast expressing Plasmodium vivax dihydrofolate reductase and in vitro drug susceptibility assay for Plasmodium falciparum

21 January 2018

1 reference

A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs

21 January 2018

1 reference

A genetic analysis of Plasmodium falciparum RNA polymerase II subunits in yeast.

21 January 2018

1 reference

The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities.

21 January 2018

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From genetics and genomics to drug discovery: yeast rises to the challenge

21 January 2018

1 reference

Apicomplexan plastids as drug targets

21 January 2018

1 reference

Toxoplasma: the next 100years.

21 January 2018

1 reference

Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites

21 January 2018

1 reference

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum

21 January 2018

1 reference

Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

21 January 2018

1 reference

Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors

21 January 2018

1 reference

Exploring metabolomic approaches to analyse phospholipid biosynthetic pathways in Plasmodium

21 January 2018

1 reference

Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition

21 January 2018

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Carotenoid biosynthesis in intraerythrocytic stages of Plasmodium falciparum

21 January 2018

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A comprehensive survey of protein palmitoylation in late blood-stage Plasmodium falciparum

21 January 2018

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Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii

21 January 2018

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Branched tricarboxylic acid metabolism in Plasmodium falciparum

21 January 2018

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Metabolic fate of fumarate, a side product of the purine salvage pathway in the intraerythrocytic stages of Plasmodium falciparum.

21 January 2018

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Plasmodium falciparum proteome changes in response to doxycycline treatment

21 January 2018

1 reference

Large-scale differential proteome analysis in Plasmodium falciparum under drug treatment

21 January 2018

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Chloroquine mediates specific proteome oxidative damage across the erythrocytic cycle of resistant Plasmodium falciparum

21 January 2018

1 reference

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

21 January 2018

1 reference

Click chemistry and bioorthogonal reactions: unprecedented selectivity in the labeling of biological molecules.

21 January 2018

1 reference

The growing impact of click chemistry on drug discovery

21 January 2018

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Genomic profiling of drug sensitivities via induced haploinsufficiency.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/FMB.11.45

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24 August 2017

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