(Q37899085)

25 August 2017

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title

Role of various proteases in cardiac remodeling and progression of heart failure (English)

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25 August 2017

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Alison L Müller

1

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PubMed ID

21739365

25 August 2017

Naranjan S Dhalla

series ordinal

2

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25 August 2017

1 May 2012

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25 August 2017

Heart Failure Reviews

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25 August 2017

17

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25 August 2017

3

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25 August 2017

395-409

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https://scigraph.springernature.com/pub.10.1007/s10741-011-9269-8

25 August 2017

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cites work

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12 December 2020

Marked differences between atrial and ventricular gene-expression remodeling in dogs with experimental heart failure

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Role of AIF in cardiac apoptosis in hypertrophic cardiomyocytes from Dahl salt-sensitive rats

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Clinical and morphological features of human hypertensive-diabetic cardiomyopathy

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Differential effects of membrane and soluble Fas ligand on cardiomyocytes: role in ischemia/reperfusion injury

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Unloading-induced remodeling in the normal and hypertrophic left ventricle

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TIMP-1: a marker of left ventricular diastolic dysfunction and fibrosis in hypertension

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Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure

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Decrease in sarcoglycans and dystrophin in failing heart following acute myocardial infarction

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The expression and significance of myocardial cathepsin L in dilated cardiomyopathy

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Targeting the calpain/calpastatin system as a new strategy to prevent cardiovascular remodeling in angiotensin II-induced hypertension

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Titin, myosin light chains and C-protein in the developing and failing human heart

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12 December 2020

Modification of sarcolemmal Na+-K+-ATPase and Na+/Ca2+ exchanger expression in heart failure by blockade of renin-angiotensin system

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12 December 2020

Membrane-type-1 matrix metalloproteinase transcription and translation in myocardial fibroblasts from patients with normal left ventricular function and from patients with cardiomyopathy.

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12 December 2020

Sarcolemmal Na(+)-K(+)-ATPase activity in congestive heart failure due to myocardial infarction

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12 December 2020

Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function

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12 December 2020

Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart

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12 December 2020

Upregulation of myocardial 11S-activated proteasome in experimental hyperglycemia

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12 December 2020

The heart in hypertension

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12 December 2020

Matrix metalloproteinase-9 is a marker of heart failure after acute myocardial infarction

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12 December 2020

A calcium stimulated cysteine protease involved in isoproterenol induced cardiac hypertrophy

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12 December 2020

MMP-2/TIMP-2/TIMP-4 versus MMP-9/TIMP-3 in transition from compensatory hypertrophy and angiogenesis to decompensatory heart failure.

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12 December 2020

Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy

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12 December 2020

Abnormalities of the extracellular degradation of collagen type I in essential hypertension

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12 December 2020

Proteasome inhibition ablates activation of NF-kappa B in myocardial reperfusion and reduces reperfusion injury

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12 December 2020

Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy

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12 December 2020

The calpain family and human disease

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12 December 2020

Unexpected cardiotoxicity in haematological bortezomib treated patients

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12 December 2020

Caspases in myocardial infarction.

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12 December 2020

Differential expression of tissue inhibitors of metalloproteinases in the failing human heart

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12 December 2020

Congestive heart failure in the diabetic

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12 December 2020

Increased matrix metalloproteinase-8 and -9 activity in patients with infarct rupture after myocardial infarction

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12 December 2020

Serum levels of large tenascin-C variants, matrix metalloproteinase-9, and tissue inhibitors of matrix metalloproteinases in concentric versus eccentric left ventricular hypertrophy

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12 December 2020

Hyperubiquitination of proteins in dilated cardiomyopathy

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12 December 2020

Altered proteasome function and subunit composition in aged muscle

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12 December 2020

The structure of calcium-free human m-calpain: implications for calcium activation and function

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12 December 2020

An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death

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12 December 2020

Caspase inhibition modulates left ventricular remodeling following myocardial infarction through cellular and extracellular mechanisms

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12 December 2020

Sarcolemmal calcium transport in congestive heart failure due to myocardial infarction in rats

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12 December 2020

Catalytic mechanism and assembly of the proteasome.

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12 December 2020

Reperfusion induces myocardial apoptotic cell death

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12 December 2020

Specialized roles for cysteine cathepsins in health and disease.

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12 December 2020

The ubiquitin-proteasome system in myocardial ischaemia and preconditioning

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12 December 2020

Elastolytic cathepsin induction/activation system exists in myocardium and is upregulated in hypertensive heart failure

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12 December 2020

Alteration of Na,K-ATPase subunit mRNA and protein levels in hypertrophied rat heart

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12 December 2020

Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription

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12 December 2020

KMUP-3 attenuates ventricular remodelling after myocardial infarction through eNOS enhancement and restoration of MMP-9/TIMP-1 balance

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12 December 2020

Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure

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12 December 2020

Proteasome activator 11S REG or PA28: recombinant REG alpha/REG beta hetero-oligomers are heptamers

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12 December 2020

Modification of cardiac subcellular remodeling due to pressure overload by captopril and losartan

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12 December 2020

Matrix metalloproteinase-9 and tissue inhibitor metalloproteinase-1 levels in essential hypertension. Relationship to left ventricular mass and anti-hypertensive therapy

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12 December 2020

Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium

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12 December 2020

Subcellular remodeling and heart dysfunction in chronic diabetes

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12 December 2020

Immunohistochemical expression of activated caspase-3 in human myocardial infarction

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12 December 2020

Proteinase 3 and prognosis of patients with acute myocardial infarction

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12 December 2020

Suppression of cardiomyocyte hypertrophy by inhibition of the ubiquitin-proteasome system

1 reference

12 December 2020

Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction

1 reference

12 December 2020

Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

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12 December 2020

Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy

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12 December 2020

Enhanced myocardial cathepsin B expression in patients with dilated cardiomyopathy

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12 December 2020

Proteasome mediates removal of proteins oxidized during myocardial ischemia

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12 December 2020

Proteasome activation as a novel antiaging strategy

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12 December 2020

Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria

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12 December 2020

Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo

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12 December 2020

The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes

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12 December 2020

Apoptosis in human acute myocardial infarction

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12 December 2020

Myocytes die by multiple mechanisms in failing human hearts

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12 December 2020

Reduced myocardial Na+, K(+)-pump capacity in congestive heart failure following myocardial infarction in rats

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12 December 2020

Functional consequences of caspase activation in cardiac myocytes

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12 December 2020

C protein-induced myocarditis and subsequent dilated cardiomyopathy: rescue from death and prevention of dilated cardiomyopathy by chemokine receptor DNA therapy

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12 December 2020

Enhanced apoptotic propensity in diabetic cardiac mitochondria: influence of subcellular spatial location

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12 December 2020

Subcellular remodelling may induce cardiac dysfunction in congestive heart failure

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12 December 2020

Myocardial matrix metalloproteinase activity and abundance with congestive heart failure

1 reference

12 December 2020

Serum matrix metalloproteinase-3 as a novel marker for risk stratification of patients with nonischemic dilated cardiomyopathy

1 reference

12 December 2020

Proteasome inhibition during myocardial infarction

1 reference

12 December 2020

Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway

1 reference

12 December 2020

Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload

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12 December 2020

Is apoptosis a diagnostic marker of acute myocardial infarction?

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12 December 2020

Long-term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodeling in rats with myocardial infarction

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12 December 2020

Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human dilated cardiomyopathy

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12 December 2020

Activation of matrix metalloproteinases precedes left ventricular remodeling in hypertensive heart failure rats: its inhibition as a primary effect of Angiotensin-converting enzyme inhibitor

1 reference

12 December 2020

Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide

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12 December 2020

Congenic expression of tissue inhibitor of metalloproteinase in Dahl-salt sensitive hypertensive rats is associated with reduced LV hypertrophy

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12 December 2020

Early detection of myocardial dysfunction and heart failure

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12 December 2020

Persistent infarct-related artery occlusion is associated with an increased myocardial apoptosis at postmortem examination in humans late after an acute myocardial infarction.

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12 December 2020

Is thrombogenesis in atrial fibrillation related to matrix metalloproteinase-1 and its inhibitor, TIMP-1?

1 reference

12 December 2020

Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.

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12 December 2020

Subcellular remodeling as a viable target for the treatment of congestive heart failure

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12 December 2020

Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation

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12 December 2020

Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling

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12 December 2020

Inhibition of granulation tissue cell apoptosis during the subacute stage of myocardial infarction improves cardiac remodeling and dysfunction at the chronic stage

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12 December 2020

Mitochondrial calpain system: an overview

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12 December 2020

Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the cell surface

1 reference

12 December 2020

Cardiomyocyte apoptosis induced by short-term diabetes requires mitochondrial GSH depletion

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12 December 2020

Don't lose heart--therapeutic value of apoptosis prevention in the treatment of cardiovascular disease.

1 reference

12 December 2020

Alterations in the pattern of collagen deposition may contribute to the deterioration of systolic function in hypertensive patients with heart failure.

1 reference

12 December 2020

Preclinical abnormality of left ventricular function in diabetes mellitus

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12 December 2020

Myocardial healing and repair after experimental infarction in the rabbit

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12 December 2020

Oxidized and ubiquitinated proteins may predict recovery of postischemic cardiac function: essential role of the proteasome.

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12 December 2020

Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor

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12 December 2020

Inhibitory kappa B kinase-beta is a target for specific nuclear factor kappa B-mediated delayed cardioprotection.

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12 December 2020

Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy.

1 reference

12 December 2020

Cardioprotective effects of a novel proteasome inhibitor following ischemia and reperfusion in the isolated perfused rat heart

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12 December 2020

Structure, activation, and biology of calpain

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12 December 2020

The roles of MMP-2/TIMP-2 in extracellular matrix remodelling in the hearts of STZ-induced diabetic rats

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12 December 2020

Subcellular remodeling and heart dysfunction in cardiac hypertrophy due to pressure overload

1 reference

12 December 2020

Cell type-specific functions of the lysosomal protease cathepsin L in the heart

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12 December 2020

Angiotensin II receptor blockade prevents microangiopathy and preserves diastolic function in the diabetic rat heart

1 reference

12 December 2020

Matrix metalloproteinases and tissue remodeling in hypertrophic cardiomyopathy.

1 reference

12 December 2020

Cathepsin cysteine proteases in cardiovascular disease.

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12 December 2020

A Matrix Metalloproteinase Induction/Activation System Exists in the Human Left Ventricular Myocardium and Is Upregulated in Heart Failure

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12 December 2020

Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion

1 reference

12 December 2020

Primary prevention of heart failure: an update

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12 December 2020

Attenuation of changes in sarcoplasmic reticular gene expression in cardiac hypertrophy by propranolol and verapamil

1 reference

12 December 2020

Many roads lead to a broken heart: the genetics of dilated cardiomyopathy

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12 December 2020

Activation of apoptotic processes during transition from hypertrophy to heart failure in guinea pigs.

1 reference

12 December 2020

Plasma tissue inhibitor of metalloproteinase-1 levels are elevated in essential hypertension and related to left ventricular hypertrophy

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12 December 2020

Cardiac remodeling rather than disturbed myocardial energy metabolism is associated with cardiac dysfunction in diabetic rats

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12 December 2020

Initiation of mitochondrial-mediated apoptosis during cardiac reperfusion

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12 December 2020

Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury

1 reference

12 December 2020

Imbalance of matrix metalloproteinases/tissue inhibitor of metalloproteinase-1 and loss of fibronectin expression in patients with congestive heart failure

1 reference

12 December 2020

Matrix metalloproteinase-1, -3, and -9 gene polymorphisms and the risk of idiopathic dilated cardiomyopathy in a Chinese Han population

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12 December 2020

Alterations in both death and survival signals for apoptosis in heart failure due to volume overload

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12 December 2020

Activation of MMP-2 as a key event in oxidative stress injury to the heart

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12 December 2020

Into the heart: the emerging role of the ubiquitin-proteasome system.

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12 December 2020

Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.

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12 December 2020

Acute severe cardiac failure in a myeloma patient due to proteasome inhibitor bortezomib

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12 December 2020

Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat

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12 December 2020

Protein degradation, aggregation, and misfolding

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12 December 2020

Altered proteasome structure, function, and oxidation in aged muscle

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12 December 2020

Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics

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12 December 2020

Myocardial remodelling and matrix metalloproteinases in heart failure: turmoil within the interstitium

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12 December 2020

High glucose reduces cathepsin L activity and impairs invasion of circulating progenitor cells

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12 December 2020

Reperfusion injury induces apoptosis in rabbit cardiomyocytes

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12 December 2020

Role of matrix metalloproteinases in hypertension-associated cardiac fibrosis

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12 December 2020

Cardiac restricted overexpression of membrane type-1 matrix metalloproteinase causes adverse myocardial remodeling following myocardial infarction

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12 December 2020

Blocking caspase-activated apoptosis improves contractility in failing myocardium

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12 December 2020

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12 December 2020

What role do extracellular matrix changes contribute to the cardiovascular disease burden of diabetes mellitus?

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12 December 2020

An antiarrhythmic effect of a chymase inhibitor after myocardial infarction

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12 December 2020

Biology of metalloproteinases

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12 December 2020

Apoptosis predominates in nonmyocytes in heart failure

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12 December 2020

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12 December 2020

Differences in cardiac calcium release channel (ryanodine receptor) expression in myocardium from patients with end-stage heart failure caused by ischemic versus dilated cardiomyopathy

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12 December 2020

Circulating matrix metalloproteinase-3 and metalloproteinase-9 and tissue Doppler measures of diastolic dysfunction to risk stratify patients with systolic heart failure

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12 December 2020

Signal pathways involved in reverse remodeling of the hypertrophic rat heart after pressure unloading.

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12 December 2020

Build it up-Tear it down: protein quality control in the cardiac sarcomere

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12 December 2020

Changes in cardiovascular function on treatment of inhibitors of apoptotic signal transduction pathways in left ventricular remodeling after myocardial infarction

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12 December 2020

Calpain activity of hypertrophic hearts from hypertensive rats

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12 December 2020

Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.

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12 December 2020

Role of matrix metalloproteinases and their tissue inhibitors as potential biomarkers of left ventricular remodelling in the athlete's heart.

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12 December 2020

β-adrenergic blockade attenuates cardiac dysfunction and myofibrillar remodelling in congestive heart failure

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12 December 2020

Inappropriate ubiquitin conjugation: a proposed mechanism contributing to heart failure

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12 December 2020

Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction

1 reference

12 December 2020

Matrix metalloproteinase (MMP)-9, but not MMP-2, is involved in the development and progression of C protein-induced myocarditis and subsequent dilated cardiomyopathy

1 reference

12 December 2020

Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease

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12 December 2020

Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury

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12 December 2020

Increased expression of calpain and elevated activity of calcineurin in the myocardium of patients with congestive heart failure.

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12 December 2020

Relative functions of the alpha and beta subunits of the proteasome activator, PA28

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12 December 2020

Pharmacologic inhibition of intracellular caspases after myocardial infarction attenuates left ventricular remodeling: a potentially novel pathway

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12 December 2020

Antioxidative treatment prevents activation of death-receptor- and mitochondrion-dependent apoptosis in the hearts of diabetic rats

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12 December 2020

Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion

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12 December 2020

Apoptosis in ischemic and reperfused rat myocardium

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12 December 2020

Mast cell-derived cathepsin g: a possible role in the adverse remodeling of the failing human heart.

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12 December 2020

Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism

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12 December 2020

Altered degradation of extracellular matrix in myocardial remodelling: the growing role of cathepsins and cystatins

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12 December 2020

Proteasome inhibition attenuates infarct size and preserves cardiac function in a murine model of myocardial ischemia-reperfusion injury.

1 reference

12 December 2020

Lysosomal and nonlysosomal proteolytic activities in experimental diabetic cardiomyopathy

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12 December 2020

In vivo myocardial infarct size reduction by a caspase inhibitor administered after the onset of ischemia

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12 December 2020

Characteristics of diabetes, blood pressure, and cardiac and renal complications in Otsuka Long-Evans Tokushima Fatty rats

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12 December 2020

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12 December 2020

Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy

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12 December 2020

Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes.

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12 December 2020

A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes

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12 December 2020

Altered expression of titin and contractile proteins in failing human myocardium

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12 December 2020

IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury

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12 December 2020

Matrilysin (MMP-7) is a major matrix metalloproteinase upregulated in biliary atresia-associated liver fibrosis

1 reference

12 December 2020

Unchanged Protein Levels of SERCA II and Phospholamban but Reduced Ca 2+ Uptake and Ca 2+ -ATPase Activity of Cardiac Sarcoplasmic Reticulum From Dilated Cardiomyopathy Patients Compared With Patients With Nonfailing Hearts

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12 December 2020

Apoptosis in heart: basic mechanisms and implications in cardiovascular diseases

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12 December 2020

Serum MMP-7 is increased in diabetic renal disease and diabetic diastolic dysfunction

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12 December 2020

In vivo administration of calpeptin attenuates calpain activation and cardiomyocyte loss in pressure-overloaded feline myocardium.

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12 December 2020

Non-specific caspase inhibition reduces infarct size and improves post-ischaemic recovery in isolated ischaemic/reperfused rat hearts

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12 December 2020

Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix

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12 December 2020

Caspase activation and mitochondrial cytochrome C release during hypoxia-mediated apoptosis of adult ventricular myocytes

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12 December 2020

Oxidative modification of proteasome: identification of an oxidation-sensitive subunit in 26 S proteasome

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12 December 2020

Gender differences in apoptotic signaling in heart failure due to volume overload

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12 December 2020

Collagen degradation in ischaemic rat hearts

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12 December 2020

10.1007/S10741-011-9269-8

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

21739365