(Q37899789)

25 August 2017

1 reference

title

Biochemistry of the non-mevalonate isoprenoid pathway (English)

1 reference

25 August 2017

4

Adelbert Bacher

1 reference

25 August 2017

5

Wolfgang Eisenreich

1 reference

25 August 2017

3

Felix Rohdich

1 reference

25 August 2017

1

Tobias Gräwert

1 reference

25 August 2017

Michael Groll

2

1 reference

25 August 2017

publication date

9 July 2011

1 reference

Cellular and Molecular Life Sciences

25 August 2017

published in

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25 August 2017

volume

68

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25 August 2017

issue

23

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25 August 2017

page(s)

3797-3814

1 reference

https://scigraph.springernature.com/pub.10.1007/s00018-011-0753-z

25 August 2017

exact match

0 references

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Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways

21 January 2018

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21 January 2018

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Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

21 January 2018

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Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin

21 January 2018

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Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors

21 January 2018

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Isoprenoid biosynthesis via the methylerythritol phosphate pathway: structural variations around phosphonate anchor and spacer of fosmidomycin, a potent inhibitor of deoxyxylulose phosphate reductoisomerase

21 January 2018

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21 January 2018

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Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors

21 January 2018

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21 January 2018

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Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods

21 January 2018

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Isoprenoid biosynthetic pathways as anti-infective drug targets

21 January 2018

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Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol

21 January 2018

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Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

21 January 2018

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Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate

21 January 2018

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Deoxyxylulose phosphate pathway to terpenoids

21 January 2018

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Biosynthesis of isoprenoids via the non-mevalonate pathway

21 January 2018

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The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates

21 January 2018

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Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids

21 January 2018

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A double mutation of Escherichia coli2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate.

21 January 2018

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Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids

21 January 2018

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A triclinic crystal form ofEscherichia coli4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure

21 January 2018

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Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

21 January 2018

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Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis

21 January 2018

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Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis

21 January 2018

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21 January 2018

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21 January 2018

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Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy.

21 January 2018

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A Structure-Based Approach to Ligand Discovery for 2 C -Methyl- d -erythritol-2,4-cyclodiphosphate Synthase: A Target for Antimicrobial Therapy †

21 January 2018

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Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli

21 January 2018

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GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli

21 January 2018

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LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli

21 January 2018

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Evidence of a role for LytB in the nonmevalonate pathway of isoprenoid biosynthesis

21 January 2018

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Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein

21 January 2018

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Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein

21 January 2018

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Phosphorylation of 1-deoxy-D-xylulose by D-xylulokinase of Escherichia coli

21 January 2018

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Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli

21 January 2018

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Biosynthesis of isoprenoids. purification and properties of IspG protein from Escherichia coli

21 January 2018

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fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis.

21 January 2018

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Flavodoxins: sequence, folding, binding, function and beyond.

21 January 2018

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IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis

21 January 2018

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Isoprenoid biosynthesis through the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) is a [4Fe-4S] protein

21 January 2018

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Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis

21 January 2018

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Isoprenoid biosynthesis in chloroplasts via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) from Arabidopsis thaliana is a [4Fe-4S] protein

21 January 2018

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LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis

21 January 2018

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Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein.

21 January 2018

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The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein

21 January 2018

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A proposed mechanism for the reductive ring opening of the cyclodiphosphate MEcPP, a crucial transformation in the new DXP/MEP pathway to isoprenoids based on modeling studies and feeding experiments

21 January 2018

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Paramagnetic intermediates of (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE/IspG) under steady-state and pre-steady-state conditions

21 January 2018

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IspG converts an epoxide substrate analogue to (E)-4-hydroxy-3-methylbut-2-enyl diphosphate: implications for IspG catalysis in isoprenoid biosynthesis.

21 January 2018

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IspG enzyme activity in the deoxyxylulose phosphate pathway: roles of the iron-sulfur cluster

21 January 2018

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Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: synthesis from an epoxide and mechanisms

21 January 2018

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Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG)

21 January 2018

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Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG

21 January 2018

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The lytB gene of Escherichia coli is essential and specifies a product needed for isoprenoid biosynthesis.

21 January 2018

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Probing the reaction mechanism of IspH protein by x-ray structure analysis

21 January 2018

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Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction

21 January 2018

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Structure of ( E )-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway

21 January 2018

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Reductive dehydroxylation of allyl alcohols by IspH protein

21 January 2018

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Isoprenoid biosynthesis via the MEP pathway: in vivo Mössbauer spectroscopy identifies a [4Fe-4S]2+ center with unusual coordination sphere in the LytB protein

21 January 2018

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Mechanistic studies of IspH in the deoxyxylulose phosphate pathway: heterolytic C-O bond cleavage at C4 position

21 January 2018

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Targeting isoprenoid biosynthesis for drug discovery: bench to bedside

21 January 2018

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Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms

21 January 2018

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Bioorganometallic mechanism of action, and inhibition, of IspH

21 January 2018

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Biosynthesis of terpenoids: efficient multistep biotransformation procedures affording isotope-labeled 2C-methyl-D-erythritol 4-phosphate using recombinant 2C-methyl-D-erythritol 4-phosphate synthase

21 January 2018

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Kinetic and chemical mechanism of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate isomeroreductase

21 January 2018

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Characterization of native and histidine-tagged deoxyxylulose 5-phosphate reductoisomerase from the cyanobacterium Synechocystis sp. PCC6803

21 January 2018

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Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding

21 January 2018

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Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin

21 January 2018

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The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation

21 January 2018

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Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis

21 January 2018

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Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis

21 January 2018

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The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target

21 January 2018

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Crystallization and preliminary X-ray crystallographic study of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Plasmodium falciparum

21 January 2018

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Identifiers

DOI

1 reference

25 August 2017

1 reference