(Q37910249)

25 August 2017

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title

Immunomodulatory therapy for severe influenza (English)

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25 August 2017

2

Samira Mubareka

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25 August 2017

3

W Conrad Liles

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25 August 2017

1

Ilyse Darwish

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25 August 2017

1 July 2011

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Expert Review of Anti-infective Therapy

25 August 2017

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25 August 2017

9

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25 August 2017

7

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25 August 2017

807-822

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Influenza-associated hospitalizations in the United States

25 August 2017

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Updating the Accounts: Global Mortality of the 1918-1920 "Spanish" Influenza Pandemic

21 January 2018

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Mortality from pandemic A/H1N1 2009 influenza in England: public health surveillance study

21 January 2018

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Influenza type A in humans, mammals and birds: determinants of virus virulence, host-range and interspecies transmission.

21 January 2018

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Pathology of fatal human infection associated with avian influenza A H5N1 virus

21 January 2018

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Avian influenza A (H5N1) in 10 patients in Vietnam

21 January 2018

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Avian influenza A (H5N1) infection in humans

21 January 2018

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Update on avian influenza A (H5N1) virus infection in humans

21 January 2018

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The acute respiratory distress syndrome

21 January 2018

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Acute respiratory distress syndrome: a historical perspective

21 January 2018

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Lung pathology in fatal novel human influenza A (H1N1) infection.

21 January 2018

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The pathogenesis of influenza in humans.

21 January 2018

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Influenza virus A pathogenicity: the pivotal role of hemagglutinin

21 January 2018

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Molecular characterization of the complete genome of human influenza H5N1 virus isolates from Thailand.

21 January 2018

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(Highly pathogenic) avian influenza as a zoonotic agent.

21 January 2018

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Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses

21 January 2018

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The hemagglutinin protein of influenza A/Vietnam/1203/2004 (H5N1) contributes to hyperinduction of proinflammatory cytokines in human epithelial cells

21 January 2018

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Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice

21 January 2018

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Differential localization and function of PB1-F2 derived from different strains of influenza A virus

21 January 2018

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Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses.

21 January 2018

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A novel influenza A virus mitochondrial protein that induces cell death.

21 January 2018

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Influenza A virus PB1-F2 protein contributes to viral pathogenesis in mice

21 January 2018

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Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia

21 January 2018

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Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans

21 January 2018

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PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal models

21 January 2018

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Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza viruses

21 January 2018

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The effects of influenza A virus PB1-F2 protein on polymerase activity are strain specific and do not impact pathogenesis

21 January 2018

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A single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivo

21 January 2018

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Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N.

21 January 2018

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A single-amino-acid substitution in a polymerase protein of an H5N1 influenza virus is associated with systemic infection and impaired T-cell activation in mice

21 January 2018

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PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice

21 January 2018

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Species-specific contribution of the four C-terminal amino acids of influenza A virus NS1 protein to virulence

21 January 2018

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Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferrets

21 January 2018

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Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza

21 January 2018

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Influenza B virus NS1-truncated mutants: live-attenuated vaccine approach

21 January 2018

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NS-based live attenuated H1N1 pandemic vaccines protect mice and ferrets

21 January 2018

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The influenza virus NS1 protein: inhibitor of innate and adaptive immunity

21 January 2018

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Selective nuclear export of viral mRNAs in influenza-virus-infected cells

21 January 2018

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Multiple anti-interferon actions of the influenza A virus NS1 protein

21 January 2018

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Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus

21 January 2018

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NS1 proteins of avian influenza A viruses can act as antagonists of the human alpha/beta interferon response.

21 January 2018

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Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs

21 January 2018

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The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway

21 January 2018

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A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis

21 January 2018

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Lethal H5N1 influenza viruses escape host anti-viral cytokine responses

21 January 2018

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Large-scale sequence analysis of avian influenza isolates.

21 January 2018

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A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity

21 January 2018

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Oseltamivir-resistant influenza A viruses are transmitted efficiently among guinea pigs by direct contact but not by aerosol.

21 January 2018

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Permissive secondary mutations enable the evolution of influenza oseltamivir resistance

21 January 2018

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Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide

21 January 2018

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Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008.

21 January 2018

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Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

21 January 2018

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Avian flu: isolation of drug-resistant H5N1 virus.

21 January 2018

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Oseltamivir resistance during treatment of influenza A (H5N1) infection

21 January 2018

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Efficacy and safety of intravenous peramivir for treatment of seasonal influenza virus infection

21 January 2018

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Peramivir and its use in H1N1 influenza

21 January 2018

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Intravenous zanamivir for oseltamivir-resistant 2009 H1N1 influenza

21 January 2018

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The use of antiviral agents for the management of severe influenza.

21 January 2018

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Developing new antiviral agents for influenza treatment: what does the future hold?

21 January 2018

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Laninamivir and its prodrug, CS-8958: long-acting neuraminidase inhibitors for the treatment of influenza

21 January 2018

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Global transmission of oseltamivir-resistant influenza

21 January 2018

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Temperature-Sensitive Mutants of Influenza Virus. IV. Induction of Interferon in the Nasopharynx by Wild-Type and a Temperature-Sensitive Recombinant Virus

21 January 2018

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Early administration of oral oseltamivir increases the benefits of influenza treatment

21 January 2018

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Factors associated with case fatality of human H5N1 virus infections in Indonesia: a case series

21 January 2018

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Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009

21 January 2018

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Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection.

21 January 2018

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Infectious disease. Old drugs losing effectiveness against flu; could statins fill gap?

21 January 2018

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Meeting the challenge of influenza pandemic preparedness in developing countries

21 January 2018

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Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus

21 January 2018

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Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus

21 January 2018

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H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice.

21 January 2018

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Mice lacking both TNF and IL-1 receptors exhibit reduced lung inflammation and delay in onset of death following infection with a highly virulent H5N1 virus

21 January 2018

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CCR2-antagonist prophylaxis reduces pulmonary immune pathology and markedly improves survival during influenza infection.

21 January 2018

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Re-emergence of fatal human influenza A subtype H5N1 disease

21 January 2018

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Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia

21 January 2018

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Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells

21 January 2018

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Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?

21 January 2018

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Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tract.

21 January 2018

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Cytokine profiles induced by the novel swine-origin influenza A/H1N1 virus: implications for treatment strategies

21 January 2018

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Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection

21 January 2018

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Genomic profiling of tumor necrosis factor alpha (TNF-alpha) receptor and interleukin-1 receptor knockout mice reveals a link between TNF-alpha signaling and increased severity of 1918 pandemic influenza virus infection

21 January 2018

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Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice

21 January 2018

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Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection

21 January 2018

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TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection.

21 January 2018

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Influence of IFN-gamma on gene expression in normal human bronchial epithelial cells: modulation of IFN-gamma effects by dexamethasone.

21 January 2018

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Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapy

21 January 2018

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Combination anti-inflammatory and antiviral therapy of influenza in a cotton rat model

21 January 2018

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Human disease from influenza A (H5N1), Thailand, 2004.

21 January 2018

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H1N1 influenza A virus-associated acute lung injury: response to combination oseltamivir and prolonged corticosteroid treatment.

21 January 2018

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Azithromycin improves macrophage phagocytic function and expression of mannose receptor in chronic obstructive pulmonary disease

21 January 2018

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Anti-inflammatory effects of macrolides--an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions?

21 January 2018

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Clarithromycin inhibits type a seasonal influenza virus infection in human airway epithelial cells

21 January 2018

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Insights into the interaction between influenza virus and pneumococcus

21 January 2018

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Effect of antiviral treatment on the outcome of secondary bacterial pneumonia after influenza

21 January 2018

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Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenza

21 January 2018

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Reducing antibiotic use in influenza: challenges and rewards

21 January 2018

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Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial

21 January 2018

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Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin

21 January 2018

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Tumor necrosis factor as a mediator of inflammation in influenza A viral pneumonia

21 January 2018

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Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology

21 January 2018

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The safety of anti-tumour necrosis factor therapy in rheumatoid arthritis

21 January 2018

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Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes

21 January 2018

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Cyclooxygenases and prostaglandins: shaping up the immune response

21 January 2018

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Hyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: a mechanism for the pathogenesis of avian influenza H5N1 infection.

21 January 2018

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Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus

21 January 2018

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Pharmacologic inhibition of COX-1 and COX-2 in influenza A viral infection in mice.

21 January 2018

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Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins

21 January 2018

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Lethal dissemination of H5N1 influenza virus is associated with dysregulation of inflammation and lipoxin signaling in a mouse model of infection

21 January 2018

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Pandemic influenza: a potential role for statins in treatment and prophylaxis

21 January 2018

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Pluripotential mechanisms of cardioprotection with HMG-CoA reductase inhibitor therapy

21 January 2018

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Statins in endothelial signaling and activation

21 January 2018

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Statins attenuate high mobility group box-1 protein induced vascular endothelial activation : a key role for TLR4/NF-κB signaling pathway

21 January 2018

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HMG-1 as a late mediator of endotoxin lethality in mice

21 January 2018

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HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo

21 January 2018

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Influenza morbidity and mortality in elderly patients receiving statins: a cohort study.

21 January 2018

1 reference

New EMBO members' review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signal

21 January 2018

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

21 January 2018

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Extracellular role of HMGB1 in inflammation and sepsis.

21 January 2018

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Reversing established sepsis with antagonists of endogenous high-mobility group box 1.

21 January 2018

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HMGB1 is a potent trigger of arthritis

21 January 2018

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HMGB1 as a cytokine and therapeutic target

21 January 2018

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Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities

21 January 2018

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Glycyrrhizin inhibits influenza A virus uptake into the cell

21 January 2018

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Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice

21 January 2018

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Integration of metabolism and inflammation by lipid-activated nuclear receptors

21 January 2018

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PPAR-gamma activation as an anti-inflammatory therapy for respiratory virus infections

21 January 2018

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Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors

21 January 2018

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Increased survival after gemfibrozil treatment of severe mouse influenza

21 January 2018

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Using Complementary and Alternative Medicines to Target the Host Response during Severe Influenza

21 January 2018

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Gemfibrozil reduces release of tumor necrosis factor-alpha in peripheral blood mononuclear cells from healthy subjects and patients with coronary heart disease

21 January 2018

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Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

21 January 2018

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Pioglitazone reduces systematic inflammation and improves mortality in apolipoprotein E knockout mice with sepsis

21 January 2018

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Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone

21 January 2018

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Peroxisome proliferator-activated receptor and AMP-activated protein kinase agonists protect against lethal influenza virus challenge in mice.

21 January 2018

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Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury.

21 January 2018

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Pioglitazone reduces monocyte activation in type 2 diabetes.

21 January 2018

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Potential application of mesenchymal stem cells in acute lung injury

21 January 2018

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Therapeutic potential of mesenchymal stem cells for severe acute lung injury

21 January 2018

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Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis

21 January 2018

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Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production

21 January 2018

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Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis.

21 January 2018

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Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury

21 January 2018

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Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice.

21 January 2018

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Mesenchymal stem cells in health and disease

21 January 2018

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Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung

21 January 2018

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Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

21 January 2018

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Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza

21 January 2018

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Vascular-specific growth factors and blood vessel formation

21 January 2018

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Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

21 January 2018

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Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

21 January 2018

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Angiopoietin-1 protects the adult vasculature against plasma leakage.

21 January 2018

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Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression

21 January 2018

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Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans

21 January 2018

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Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation

21 January 2018

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Protective role of angiopoietin-1 in endotoxic shock.

21 January 2018

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Cell-based angiopoietin-1 gene therapy for acute lung injury.

21 January 2018

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Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1

21 January 2018

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COMP-angiopoietin-1 decreases lipopolysaccharide-induced acute kidney injury

21 January 2018

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Acceleration of diabetic wound healing by an angiopoietin peptide mimetic

21 January 2018

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Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/ERI.11.56

1 reference

25 August 2017

1 reference

PubMed ID

21810053