(Q37925164)

25 August 2017

1 reference

title

Wnt signaling and colon tumorigenesis--a view from the periphery (English)

1 reference

25 August 2017

Antony W Burgess

1

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25 August 2017

Maree C Faux

series ordinal

2

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25 August 2017

Meredith J Layton

series ordinal

3

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25 August 2017

Robert G Ramsay

series ordinal

4

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25 August 2017

language of work or name

English

0 references

publication date

22 August 2011

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Experimental Cell Research

25 August 2017

published in

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25 August 2017

volume

317

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25 August 2017

issue

19

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25 August 2017

page(s)

2748-2758

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APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"

25 August 2017

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Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

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7 January 2021

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A two-step model for colon adenoma initiation and progression caused by APC loss

7 January 2021

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The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.

7 January 2021

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Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

7 January 2021

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Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability

7 January 2021

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Identification of stem cells in small intestine and colon by marker gene Lgr5

7 January 2021

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LRIG inhibitors of growth factor signalling - double-edged swords in human cancer?

7 January 2021

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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

7 January 2021

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A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt

7 January 2021

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7 January 2021

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Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1.

7 January 2021

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Stem cells and their implications for colorectal cancer.

7 January 2021

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Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf

7 January 2021

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Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism

7 January 2021

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c-Myb is required for progenitor cell homeostasis in colonic crypts.

7 January 2021

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MYB function in normal and cancer cells

7 January 2021

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Insights into c-Myb functions through investigating colonic crypts

7 January 2021

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Linking colorectal cancer to Wnt signaling

7 January 2021

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From gut homeostasis to cancer

7 January 2021

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Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

β-catenin is a target for the ubiquitin–proteasome pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

The ubiquitin ligase SCF(betaTrCP) regulates the degradation of the growth hormone receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Association of the APC gene product with beta-catenin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Association of the APC tumor suppressor protein with catenins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

beta-catenin destruction complex: insights and questions from a structural perspective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Systematic peptide array-based delineation of the differential beta-catenin interaction with Tcf4, E-cadherin, and adenomatous polyposis coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Complete deletion of Apc results in severe polyposis in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Recruitment of adenomatous polyposis coli and beta-catenin to axin-puncta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Cell regulation by the Apc protein Apc as master regulator of epithelia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Regulated binding of adenomatous polyposis coli protein to actin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Identification of a link between the tumour suppressor APC and the kinesin superfamily

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Asef, a link between the tumor suppressor APC and G-protein signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Adenomatous polyposis coli regulates endothelial cell migration independent of roles in beta-catenin signaling and cell-cell adhesion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Independent interactions of phosphorylated β-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Functional correlates of mutations in beta-catenin exon 3 phosphorylation sites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Colorectal cancer and genetic alterations in the Wnt pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Wnt-5a-CKI{alpha} signaling promotes {beta}-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

A novel role of phospho-beta-catenin in microtubule regrowth at centrosome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Terminal regions of beta-catenin come into view

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Inositol pentakisphosphate mediates Wnt/beta-catenin signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

O-GlcNAc-glycosylation of beta-catenin regulates its nuclear localization and transcriptional activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

PIPKIγ regulates β-catenin transcriptional activity downstream of growth factor receptor signaling.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Wnt/beta-catenin signaling in development and disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Drosophila Tcf and Groucho interact to repress Wingless signalling activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Identification of c-MYC as a target of the APC pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

An evaluation of 3C-based methods to capture DNA interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Assaying beta-catenin/TCF transcription with beta-catenin/TCF transcription-based reporter constructs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

A Tcf4-GFP reporter mouse model for monitoring effects of Apc mutations during intestinal tumorigenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Inflammation and colon cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Inhibition of intestinal polyposis with reduced angiogenesis in ApcMin/+ mice due to decreases in c-Myc expression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Histogenesis of human colorectal adenomas and hyperplastic polyps: the role of cell proliferation and crypt fission.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Crypt stem cells as the cells-of-origin of intestinal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Intestinal stem cell replacement follows a pattern of neutral drift

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Smad3 contributes to positioning of proliferating cells in colonic crypts by inducing EphB receptor protein expression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Preparation of wholemount mouse intestine for high-resolution three-dimensional imaging using two-photon microscopy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Effect of transforming growth factor-alpha on enterocyte apoptosis is correlated with EGF receptor expression along the villus-crypt axis during methotrexate-induced intestinal mucositis in a rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Fibroblast growth factor receptor-3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Krüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Computational model of cell positioning: directed and collective migration in the intestinal crypt epithelium.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

Efficient Wnt mediated intestinal hyperproliferation requires the cyclin D2-CDK4/6 complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.010

10.1016/J.YEXCR.2011.08.010

7 January 2021

Identifiers

DOI

1 reference

25 August 2017

1 reference