(Q39766205)

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Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients

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scholarly article

1 reference

Europe PubMed Central

14 September 2017

Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients (English)

1 reference

Europe PubMed Central

14 September 2017

author name string

E M Kohler

1

1 reference

Europe PubMed Central

14 September 2017

K Brauburger

2

1 reference

Europe PubMed Central

14 September 2017

J Behrens

3

1 reference

Europe PubMed Central

14 September 2017

J Schneikert

4

1 reference

Europe PubMed Central

14 September 2017

language of work or name

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publication date

7 December 2009

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Europe PubMed Central

14 September 2017

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Europe PubMed Central

14 September 2017

29

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Europe PubMed Central

14 September 2017

1663-1671

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Europe PubMed Central

14 September 2017

11

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Europe PubMed Central

14 September 2017

https://scigraph.springernature.com/pub.10.1038/onc.2009.447

0 references

Wnt signalling and the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Crypt stem cells as the cells-of-origin of intestinal cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Functional interaction of beta-catenin with the transcription factor LEF-1

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Wnt signalling in the mouse intestine

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Wnt/beta-catenin signaling in development and disease

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Chemical dissection of the APC Repeat 3 multistep phosphorylation by the concerted action of protein kinases CK1 and GSK3.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Wnt/beta-catenin signaling in cancer stemness and malignant behavior

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Identification and characterization of the familial adenomatous polyposis coli gene

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Protecting genomic integrity in somatic cells and embryonic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Down-regulation of beta-catenin by the colorectal tumor suppressor APC requires association with Axin and beta-catenin.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

beta-catenin destruction complex: insights and questions from a structural perspective

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Genetic mechanisms in Apc-mediated mammary tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Cell regulation by the Apc protein Apc as master regulator of epithelia.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Difference in characteristics of APC mutations between colonic and extracolonic tumors of FAP patients: variations with phenotype.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

The many ways of Wnt in cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

APC mutations occur early during colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Association of the APC gene product with beta-catenin

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Truncated APC is required for cell proliferation and DNA replication.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

The canonical Wnt signalling pathway and its APC partner in colon cancer development

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Colorectal cancer and genetic alterations in the Wnt pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Association of the APC tumor suppressor protein with catenins

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Wnt signaling and gastrointestinal tumorigenesis in mouse models

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Functional Characterization of the Novel APC N1026S Variant Associated With Attenuated Familial Adenomatous Polyposis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.447

21 January 2018

Identifiers

10.1038/ONC.2009.447

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

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