(Q37942089)

25 August 2017

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title

Regulation of α-secretase ADAM10 expression and activity (English)

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25 August 2017

Kristina Endres

1

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25 August 2017

Falk Fahrenholz

series ordinal

2

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25 August 2017

publication date

4 October 2011

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25 August 2017

number of pages

10

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Experimental Brain Research

inferred from page(s)

published in

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25 August 2017

volume

217

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25 August 2017

issue

3-4

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25 August 2017

page(s)

343-352

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https://scigraph.springernature.com/pub.10.1007/s00221-011-2885-7

25 August 2017

exact match

0 references

cites work

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21 January 2018

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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

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β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation

21 January 2018

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Platelets provide human tissue to unravel pathogenic mechanisms of Alzheimer disease.

21 January 2018

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The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity

21 January 2018

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The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains.

21 January 2018

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BACE1 mRNA expression in Alzheimer's disease postmortem brain tissue

21 January 2018

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Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17.

21 January 2018

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SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

21 January 2018

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Upregulation of the alpha-secretase ADAM10--risk or reason for hope?

21 January 2018

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Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation

21 January 2018

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Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases

21 January 2018

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Searching for new animal models of Alzheimer's disease.

21 January 2018

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Functional role of N-glycosylation from ADAM10 in processing, localization and activity of the enzyme.

21 January 2018

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Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease

21 January 2018

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Alpha-secretase as a therapeutic target

21 January 2018

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CSF APPs alpha and phosphorylated tau protein levels in mild cognitive impairment and dementia of Alzheimer's type

21 January 2018

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A non-amyloidogenic function of BACE-2 in the secretory pathway

21 January 2018

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The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1.

21 January 2018

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Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

21 January 2018

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Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus

21 January 2018

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ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo

21 January 2018

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The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity

21 January 2018

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Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway

21 January 2018

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Platelet alpha- and beta- secretase activities are not significantly affected by dementia or mild cognitive impairment in Swedish patients.

21 January 2018

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Beta-site APP cleaving enzyme 1 (BACE1) is increased in remaining neurons in Alzheimer's disease brains

21 January 2018

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Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein

21 January 2018

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21 January 2018

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Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

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Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β.

21 January 2018

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The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

21 January 2018

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Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice.

21 January 2018

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Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

21 January 2018

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Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's diseas

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

A review of acitretin, a systemic retinoid for the treatment of psoriasis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

An arginine stretch limits ADAM10 exit from the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Can statins prevent or help treat Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

BACE1 activity in cerebrospinal fluid and its relation to markers of AD pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Vitamin A exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Quantitative changes in the amyloid βA4 precursor protein in Alzheimer cerebrospinal fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role--relevance for Alzheimer pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Platelet amyloid precursor protein processing: a bio-marker for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Soluble amyloid precursor protein alpha reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

alpha- and beta-secretase: profound changes in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Decrease in age-adjusted cerebrospinal fluid beta-secretase activity in Alzheimer's subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Assignment of a disintegrin and metalloproteinase domain 10 (Adam10) gene to mouse chromosome 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Radiation hybrid mapping of human ADAM10 gene to chromosome 15

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Levels of beta-secretase (BACE1) in cerebrospinal fluid as a predictor of risk in mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

Coordinated Expression of β-Amyloid Precursor Protein and the Putative β-Secretase BACE and α-Secretase ADAM10 in Mouse and Human Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2885-7

ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles

21 January 2018

1 reference

12 December 2020

beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.

1 reference

12 December 2020

Genomic structure and functional characterization of the human ADAM10 promoter

1 reference

12 December 2020

The non-amyloidogenic pathway: structure and function of alpha-secretases

1 reference

12 December 2020

Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients

1 reference

12 December 2020

Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases.

1 reference

12 December 2020

The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein

1 reference

12 December 2020

Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice

1 reference

12 December 2020

SAP97-mediated local trafficking is altered in Alzheimer disease patients' hippocampus.

1 reference

12 December 2020

Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease

1 reference

12 December 2020

[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients

1 reference

12 December 2020

10.1007/S00221-011-2885-7

Identifiers

DOI

1 reference

25 August 2017

1 reference