(Q42870334)

English

Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice

scientific article published on 18 May 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice (English)

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Alzheimer's disease

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author name string

Dorothea Rat

1

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Ulrich Schmitt

2

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Frank Tippmann

3

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Ilse Dewachter

4

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Clara Theunis

5

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Ewa Wieczerzak

6

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Rolf Postina

7

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Fred van Leuven

8

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Falk Fahrenholz

9

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Elzbieta Kojro

10

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Europe PubMed Central

PMC publication ID

9 November 2017

language of work or name

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publication date

18 May 2011

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

25

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

9

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

3208-3218

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β.

1 reference

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27 May 2018

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

1 reference

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27 May 2018

SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

1 reference

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27 May 2018

Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis

1 reference

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27 May 2018

Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery.

1 reference

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Detection of behavioral alterations and learning deficits in mice lacking synaptophysin.

1 reference

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27 May 2018

Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin

1 reference

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27 May 2018

Role of PACAP and VIP in astroglial functions

1 reference

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Pulmonary and systemic effects of inhaled PACAP38 in healthy male subjects

1 reference

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27 May 2018

Intravenous infusion of pituitary adenylate cyclase-activating polypeptide (PACAP) in a patient with multiple myeloma and myeloma kidney: a case study

1 reference

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27 May 2018

Microarray analyses of pituitary adenylate cyclase activating polypeptide (PACAP)-regulated gene targets in sympathetic neurons

1 reference

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27 May 2018

Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells

1 reference

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27 May 2018

Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.

1 reference

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27 May 2018

Nasal clearance in health and disease

1 reference

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27 May 2018

Alzheimer's amyloid beta-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: an intriguing role for methionine 35.

1 reference

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27 May 2018

The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein

1 reference

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27 May 2018

Understanding RAGE, the receptor for advanced glycation end products

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27 May 2018

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

1 reference

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27 May 2018

Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit CBP-NF-kappaB interaction in activated microglia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157688

27 May 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

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27 May 2018

Sniffing neuropeptides: a transnasal approach to the human brain

1 reference

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27 May 2018

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

1 reference

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27 May 2018

Intranasal delivery of morphine

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Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB

1 reference

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27 May 2018

The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32

1 reference

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27 May 2018

Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit nuclear factor-kappa B-dependent gene activation at multiple levels in the human monocytic cell line THP-1.

1 reference

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Transport of drugs from the nasal cavity to the central nervous system

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Activity-dependent neurotrophic factor: intranasal administration of femtomolar-acting peptides improve performance in a water maze.

1 reference

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27 May 2018

Synergistic induction of pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression by nerve growth factor and PACAP in PC12 cells

1 reference

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27 May 2018

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

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27 May 2018

VIP and PACAP potentiate the action of glutamate on BDNF expression in mouse cortical neurones

1 reference

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27 May 2018

Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism

1 reference

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27 May 2018

Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices

1 reference

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Prevention of ischemia-induced death of hippocampal neurons by pituitary adenylate cyclase activating polypeptide

1 reference

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27 May 2018

Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on gonadotropin-releasing hormone and somatostatin gene expression in the rat brain

1 reference

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27 May 2018

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

1 reference

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Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion

1 reference

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Differential signal transduction by five splice variants of the PACAP receptor

1 reference

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Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

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Hydrogen peroxide mediates amyloid beta protein toxicity

1 reference

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Demonstration of specific binding sites for pituitary adenylate cyclase activating polypeptide (PACAP) in rat astrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157688

27 May 2018

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157688

27 May 2018

Pituitary adenylate cyclase-activating polypeptide protects astroglial cells against oxidative stress-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157688

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Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

1 reference

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M1 receptors play a central role in modulating AD-like pathology in transgenic mice

1 reference

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PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone

1 reference

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Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease

1 reference

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1 reference

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Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons.

1 reference

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1 reference

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Reduced expression of brain-derived neurotrophic factor in mice deficient for pituitary adenylate cyclase activating polypeptide type-I-receptor

1 reference

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Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone.

1 reference

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Expression of the receptor for pituitary adenylate cyclase-activating polypeptide (PAC1-R) in reactive astrocytes

1 reference

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alpha- and beta-secretase: profound changes in Alzheimer's disease.

1 reference

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Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

1 reference

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Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro

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Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease.

1 reference

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Identification of a signaling pathway involved in calcium regulation of BDNF expression

1 reference

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The pituitary adenylate cyclase-activating polypeptide-induced phosphorylation of the transcription factor CREB (cAMP response element binding protein) in the rat suprachiasmatic nucleus is inhibited by melatonin

1 reference

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Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation

1 reference

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1 reference

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Regulation of interleukin-6 (IL-6) secretion in primary cultured rat astrocytes: synergism of interleukin-1 (IL-1) and pituitary adenylate cyclase activating polypeptide (PACAP).

1 reference

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Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's diseas

1 reference

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Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21593432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1096/FJ.10-180133

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

ResearchGate publication ID

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