(Q42675168)

English

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

scientific article published on May 2002

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scholarly article

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Europe PubMed Central

4 November 2017

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice (English)

1 reference

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12 May 2020

long-term potentiation

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inferred from title

8

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Lieve Umans

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Ilse Dewachter

1

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12 May 2020

Delphine Reversé

2

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12 May 2020

Nathalie Caluwaerts

3

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12 May 2020

Laurence Ris

4

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12 May 2020

Cuno Kuipéri

5

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12 May 2020

Chris Van den Haute

6

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12 May 2020

Kurt Spittaels

7

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12 May 2020

Lieve Umans

8

1 reference

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12 May 2020

Lutgarde Serneels

9

1 reference

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12 May 2020

Els Thiry

10

1 reference

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12 May 2020

Dieder Moechars

11

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12 May 2020

Mark Mercken

12

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12 May 2020

Emile Godaux

13

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12 May 2020

Fred Van Leuven

14

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12 May 2020

language of work or name

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publication date

1 May 2002

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4 November 2017

Journal of Neuroscience

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12 May 2020

22

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12 May 2020

9

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12 May 2020

3445-3453

1 reference

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12 May 2020

Presenilins as therapeutic targets for the treatment of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memory and long-term potentiation (LTP) dissociated: normal spatial memory despite CA1 LTP elimination with Kv1.4 antisense

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Short-term synaptic plasticity is altered in mice lacking synapsin I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice expressing Alzheimer amyloid precursor proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired learning in mice with abnormal short-lived plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired long-term potentiation induction in dentate gyrus of calretinin-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An etiological role of amyloidogenic carboxyl-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A portrait of Alzheimer secretases--new features and familiar faces

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Standardization of measurement of beta-amyloid(1-42) in cerebrospinal fluid and plasma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-mediated modulation of capacitative calcium entry

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 regulates neuronal differentiation during neurogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium stores regulate the polarity and input specificity of synaptic modification

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic plasticity and memory: an evaluation of the hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal synaptic plasticity in mice overexpressing an embryonic subunit of the NMDA receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of A beta and carboxyl terminal peptide fragments of amyloid precursor protein in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of long-term potentiation by beta-amyloid peptides in the CA1 region of the rat hippocampus in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presenilins in Alzheimer's disease--proteolysis holds the key.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic enhancement of learning and memory in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cre-mediated somatic site-specific recombination in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progress in the modeling of neurodegenerative diseases in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11978821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-09-03445.2002

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758348&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758348&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758348&resulttype=core&format=json

12 May 2020

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