(Q34265143)

1 August 2017

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title

Presenilins as therapeutic targets for the treatment of Alzheimer's disease (English)

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1 August 2017

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Golde TE

1

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1 August 2017

Younkin SG

series ordinal

2

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1 August 2017

publication date

1 June 2001

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Trends in Molecular Medicine

1 August 2017

published in

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1 August 2017

volume

7

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1 August 2017

issue

6

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1 August 2017

page(s)

264-269

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Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease

1 August 2017

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

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7 January 2021

Amyloid, the presenilins and Alzheimer's disease

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7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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7 January 2021

The role of A beta 42 in Alzheimer's disease

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7 January 2021

The presenilins in Alzheimer's disease--proteolysis holds the key.

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7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons.

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Cellular mechanisms of beta-amyloid production and secretion

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7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

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7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

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7 January 2021

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

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7 January 2021

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

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7 January 2021

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

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7 January 2021

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

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7 January 2021

Cell-free assays for gamma-secretase activity

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7 January 2021

The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.

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7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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7 January 2021

Presenilins: molecular switches between proteolysis and signal transduction

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7 January 2021

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

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7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

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7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

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7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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7 January 2021

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain

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7 January 2021

Presenilin structure, function and role in Alzheimer disease.

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7 January 2021

Binding partners of Alzheimer's disease proteins: are they physiologically relevant?

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7 January 2021

Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice

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7 January 2021

Presenilin-mediated modulation of capacitative calcium entry

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7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

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7 January 2021

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

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7 January 2021

Lack of requirement for presenilin1 in Notch1 signaling.

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7 January 2021

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

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7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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7 January 2021

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

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7 January 2021

Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase

1 reference

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7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902064-0

7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902064-0

7 January 2021

10.1016/S1471-4914(01)02064-0

Identifiers

DOI

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1 August 2017

1 reference