(Q37949231)

25 August 2017

Resistance to type 2 diabetes mellitus: a matter of hormesis? (English)

1 reference

25 August 2017

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Hubert Kolb

1

1 reference

PubMed ID

22024974

25 August 2017

Décio L Eizirik

series ordinal

2

1 reference

25 August 2017

25 October 2011

1 reference

Nature Reviews Endocrinology

25 August 2017

1 reference

25 August 2017

8

1 reference

25 August 2017

3

1 reference

25 August 2017

183-192

1 reference

https://scigraph.springernature.com/pub.10.1038/nrendo.2011.158

25 August 2017

0 references

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High glucose induces toll-like receptor expression in human monocytes: mechanism of activation

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Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes

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Elevated endotoxin levels in non-alcoholic fatty liver disease

21 January 2018

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Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects

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Different TNFalpha expression elicited by glucose in monocytes from type 2 diabetes mellitus patients.

21 January 2018

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High interleukin-12 production from stimulated peripheral blood mononuclear cells of type 2 diabetes patients

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Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects

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Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study

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Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors

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Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo

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Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals.

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Postprandial variations of plasma inflammatory markers in abdominally obese men.

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Prolonged reactive oxygen species generation and nuclear factor-kappaB activation after a high-fat, high-carbohydrate meal in the obese.

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The metabolic syndrome sensitizes leukocytes for glucose-induced immune gene expression.

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Obese reproductive-age women exhibit a proatherogenic inflammatory response during hyperglycemia

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Adiponectin promotes endotoxin tolerance in macrophages by inducing IRAK-M expression.

21 January 2018

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Reactive oxygen species production by mitochondria.

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Mitochondrial glutathione, a key survival antioxidant

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Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

21 January 2018

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Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells.

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High glucose induces IL-1beta expression in human monocytes: mechanistic insights

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Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity

21 January 2018

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Antioxidants prevent health-promoting effects of physical exercise in humans

21 January 2018

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Antioxidant supplementation reduces skeletal muscle mitochondrial biogenesis.

21 January 2018

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Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway

21 January 2018

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Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice.

21 January 2018

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AMPK and PPARdelta agonists are exercise mimetics

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How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

21 January 2018

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Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet

21 January 2018

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Mild thermotolerance induced at 40 degrees C increases antioxidants and protects HeLa cells against mitochondrial apoptosis induced by hydrogen peroxide: Role of p53.

21 January 2018

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21 January 2018

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Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity

21 January 2018

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C. elegans as model for the study of high glucose- mediated life span reduction

21 January 2018

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Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Contrasting clinical and cardiovascular risk status between early and later onset type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Early-onset Type 2 diabetes mellitus: an increasing phenomenon of elevated cardiovascular risk

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Extremely short duration high intensity interval training substantially improves insulin action in young healthy males

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Improved insulin sensitivity after exercise: focus on insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals

21 January 2018

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Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up.

21 January 2018

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Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

21 January 2018

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The role for endoplasmic reticulum stress in diabetes mellitus

21 January 2018

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Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

21 January 2018

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Signal integration in the endoplasmic reticulum unfolded protein response

21 January 2018

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

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Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction

21 January 2018

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Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

21 January 2018

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Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1.

21 January 2018

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A subcytotoxic dose of subtilase cytotoxin prevents lipopolysaccharide-induced inflammatory responses, depending on its capacity to induce the unfolded protein response

21 January 2018

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

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Involvement of endoplasmic reticulum stress in insulin resistance and diabetes

21 January 2018

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GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

21 January 2018

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Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance

21 January 2018

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Deletion of Nck1 attenuates hepatic ER stress signaling and improves glucose tolerance and insulin signaling in liver of obese mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex

21 January 2018

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ER stress and hormetic regulation of the aging process

21 January 2018

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High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress

21 January 2018

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Heat shock protein hsp70 overexpression confers resistance against nitric oxide

21 January 2018

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Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms

21 January 2018

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Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

21 January 2018

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Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs

21 January 2018

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Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins

21 January 2018

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ER stress in pancreatic beta cells: the thin red line between adaptation and failure

21 January 2018

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Protection of Renal Epithelial Cells against Oxidative Injury by Endoplasmic Reticulum Stress Preconditioning Is Mediated by ERK1/2 Activation

21 January 2018

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Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

21 January 2018

1 reference

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Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets.

21 January 2018

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The effects of glucagon-like peptide-1 on the beta cell

21 January 2018

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AMPK and SIRT1: a long-standing partnership?

21 January 2018

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Sirtuin-1 regulation of mammalian metabolism

21 January 2018

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Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism.

21 January 2018

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Current status of islet cell replacement and regeneration therapy

21 January 2018

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Beta cell regeneration in human pancreas

21 January 2018

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'Giving and taking': endothelial and beta-cells in the islets of Langerhans

21 January 2018

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Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits

21 January 2018

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Genetics of type 2 diabetes.

21 January 2018

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Hyperglycemia-induced B cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background

21 January 2018

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Association of SIRT1 gene variation with visceral obesity

21 January 2018

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Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study

21 January 2018

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SIRT1 genetic variation is related to BMI and risk of obesity

21 January 2018

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SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study

21 January 2018

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The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis.

21 January 2018

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Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: a HuGE review and meta-analysis

21 January 2018

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

21 January 2018

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Sensing of energy and nutrients by AMP-activated protein kinase.

21 January 2018

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Activation of leukocytes by postprandial lipemia in healthy volunteers

21 January 2018

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Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Meal modulation of circulating interleukin 18 and adiponectin concentrations in healthy subjects and in patients with type 2 diabetes mellitus.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Type 2 diabetes and lipoprotein metabolism affect LPS-induced cytokine and chemokine release in primary human monocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

The obese healthy paradox: is inflammation the answer?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

The effect of rowing on endothelial function and insulin action in healthy controls and in patients with type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Low stress response enhances vulnerability of islet cells in diabetes-prone BB rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1 beta-induced impaired beta-cell function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

Interleukin-1beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.158

High-glycemic index carbohydrate increases nuclear factor-kappaB activation in mononuclear cells of young, lean healthy subjects

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22024974

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Natural antibiotics and insulin sensitivity: the role of bactericidal/permeability-increasing protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22024974

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRENDO.2011.158

1 reference

25 August 2017

1 reference

PubMed ID

22024974