(Q54397165)

English

Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice.

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scholarly article

1 reference

Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice. (English)

1 reference

Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

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1 reference

ChEBI release 2020-05-28

insulin resistance

1 reference

based on heuristic

inferred from title

author name string

Z Yu

1

1 reference

Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

W Shao

2

1 reference

Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

Y Chiang

3

1 reference

Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

W Foltz

4

1 reference

Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

Z Zhang

5

1 reference

Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

W Ling

6

1 reference

Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

I G Fantus

7

1 reference

Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

T Jin

8

1 reference

Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

publication date

16 December 2010

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Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

1 reference

Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

54

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Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

4

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Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

922-934

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Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

https://scigraph.springernature.com/pub.10.1007/s00125-010-2001-8

0 references

Insulin resistance is a cellular antioxidant defense mechanism

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

Reactive oxygen species have a causal role in multiple forms of insulin resistance

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

Increased oxidative stress in obesity and its impact on metabolic syndrome

1 reference

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Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle

1 reference

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N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress

1 reference

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S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.

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Nitrosative stress and pathogenesis of insulin resistance

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Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure.

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Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

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1 reference

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Nrf2:INrf2 (Keap1) signaling in oxidative stress

1 reference

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Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1.

1 reference

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Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats

1 reference

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Upregulation of the heme oxygenase system ameliorates postprandial and fasting hyperglycemia in type 2 diabetes

1 reference

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Influence of alpha-lipoic acid on lipid peroxidation and antioxidant defence system in blood of insulin-resistant rats

1 reference

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Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction

1 reference

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Nrf2 as a novel molecular target for chemoprevention

1 reference

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Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

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Cyclic AMP signaling stimulates proteasome degradation of thioredoxin interacting protein (TxNIP) in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

Insulin stimulates the expression of carbohydrate response element binding protein (ChREBP) by attenuating the repressive effect of Pit-1, Oct-1/Oct-2, and Unc-86 homeodomain protein octamer transcription factor-1.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

AMPK activation attenuates S6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

Antioxidant and mitochondrial protective effects of oxidized metabolites of oltipraz

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

Therapeutic potential of dithiolethiones for hepatic diseases

1 reference

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21 January 2018

Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

Reactive oxygen species enhance insulin sensitivity

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-2001-8

21 January 2018

Metabolic syndrome and oxidative stress

1 reference

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21 January 2018

Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?

1 reference

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Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling

1 reference

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New evaluations of redox regulating system in adipose tissue of obesity

1 reference

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Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase

1 reference

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21 January 2018

Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue

1 reference

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Inflamed adipose tissue, insulin resistance and vascular injury

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Inhibition of arachidonic acid and iron-induced mitochondrial dysfunction and apoptosis by oltipraz and novel 1,2-dithiole-3-thione congeners

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NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis

1 reference

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Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity

1 reference

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Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

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Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21161163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21161163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dignam and Roeder Nuclear Extract Preparation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21161163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21161163

12 December 2020

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inferred from PubMed ID database lookup

Pathophysiology of insulin resistance in human disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21161163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-010-2001-8

1 reference

Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

1 reference

Europe PubMed Central

29 May 2018

http://europepmc.org/abstract/MED/21161163

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