(Q37679901)

21 August 2017

1 reference

title

Antioxidant and mitochondrial protective effects of oxidized metabolites of oltipraz (English)

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21 August 2017

1 reference

ChEBI release 2020-05-28

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Song Hwa Choi

1

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21 August 2017

Young Mi Kim

series ordinal

2

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21 August 2017

Jung Min Lee

series ordinal

3

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21 August 2017

Sang Geon Kim

series ordinal

4

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21 August 2017

language of work or name

English

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publication date

1 February 2010

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Expert Opinion on Drug Metabolism & Toxicology

21 August 2017

published in

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21 August 2017

volume

6

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21 August 2017

issue

2

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21 August 2017

page(s)

213-224

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Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz

21 August 2017

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

21 January 2018

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Inhibition of TGFbeta1-mediated PAI-1 induction by oltipraz through selective interruption of Smad 3 activation

21 January 2018

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Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway

21 January 2018

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Inhibition of arachidonic acid and iron-induced mitochondrial dysfunction and apoptosis by oltipraz and novel 1,2-dithiole-3-thione congeners

21 January 2018

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Pharmacokinetic changes of oltipraz after intravenous and oral administration to rats with liver cirrhosis induced by dimethylnitrosamine

21 January 2018

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Interspecies pharmacokinetic scaling of oltipraz in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics

21 January 2018

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Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane

21 January 2018

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Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (Oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard.

21 January 2018

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Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

21 January 2018

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Differential effects of the oxidized metabolites of oltipraz on the activation of CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 for GSTA2 gene induction

21 January 2018

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Thiolytic chemistry of alternative precursors to the major metabolite of the cancer chemopreventive oltipraz

21 January 2018

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Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemoprevention

21 January 2018

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Cytochrome c, an ideal antioxidant

21 January 2018

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Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine.

21 January 2018

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Apoptosis in the embryo and tumorigenesis

21 January 2018

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Oxygen radicals and human disease

21 January 2018

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Vitamin C as an antioxidant: evaluation of its role in disease prevention

21 January 2018

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The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate

21 January 2018

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Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway

21 January 2018

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Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes

21 January 2018

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Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903427972

The role of mitochondria in reactive oxygen species metabolism and signaling

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903427972

Polarographic assay and intracellular distribution of superoxide dismutase in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Oxidized metabolites of oltipraz exert cytoprotective effects against arachidonic acid through AMP-activated protein kinase-dependent cellular antioxidant effect and mitochondrial protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Chemoprotection against cancer by phase 2 enzyme induction

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903427972

Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903427972

Chemopreventive activity of oltipraz.

21 January 2018

1 reference

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Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Phase 2 enzyme induction by the major metabolite of oltipraz

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903427972

Regulatory mechanisms of cellular response to oxidative stress

21 January 2018

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Nrf2-Keap1 defines a physiologically important stress response mechanism

21 January 2018

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CCAAT/enhancer-binding proteins: structure, function and regulation

21 January 2018

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Signal transduction in the liver: C/EBPbeta modulates cell proliferation and survival

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903427972

Cancer chemopreventive oltipraz generates superoxide anion radical

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Mechanism of rat UDP-glucuronosyltransferase 1A6 induction by oltipraz: evidence for a contribution of the Aryl hydrocarbon receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

21 January 2018

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Interaction and functional collaboration of p300 and C/EBPbeta

21 January 2018

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Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

21 January 2018

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Mitochondrial permeability transition is a central coordinating event of apoptosis

21 January 2018

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Release of cytochrome c from liver mitochondria during permeability transition.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903427972

Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release

21 January 2018

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Mitochondria permeability transition-dependent tert-butyl hydroperoxide-induced apoptosis in hepatoma HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adeni

21 January 2018

1 reference

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Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

AMPK: a metabolic gauge regulating whole-body energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

LKB1-dependent signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Resveratrol stimulates AMP kinase activity in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Catechin-induced activation of the LKB1/AMP-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Abrogation of hyperosmotic impairment of insulin signaling by a novel class of 1,2-dithiole-3-thiones through the inhibition of S6K1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Superoxide radical and superoxide dismutases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Oltipraz stimulates the transcription of the manganese superoxide dismutase gene in rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Oxidized redox state of glutathione in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

The mammalian unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

The endoplasmic reticulum and the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

Endoplasmic Reticulum Stress Induces Apoptosis by an Apoptosome-dependent but Caspase 12-independent Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903427972

10.1517/17425250903427972

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference