(Q37949571)

25 August 2017

title

Vemurafenib (PLX4032): an orally available inhibitor of mutated BRAF for the treatment of metastatic melanoma (English)

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25 August 2017

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ChEBI release 2020-05-28

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2

Mark Kester

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25 August 2017

Yasser Heakal

1

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25 August 2017

Scott Savage

series ordinal

3

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25 August 2017

language of work or name

English

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publication date

25 October 2011

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Annals of Pharmacotherapy

25 August 2017

published in

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25 August 2017

volume

45

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25 August 2017

issue

11

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25 August 2017

page(s)

1399-1405

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Management of cutaneous melanoma

25 August 2017

cites work

1 reference

21 January 2018

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

21 January 2018

1 reference

Ipilimumab plus dacarbazine for previously untreated metastatic melanoma

21 January 2018

1 reference

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

21 January 2018

1 reference

Ras history: The saga continues

21 January 2018

1 reference

BRAF, a target in melanoma: implications for solid tumor drug development

21 January 2018

1 reference

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models

21 January 2018

1 reference

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

21 January 2018

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Targeting cancer with small molecule kinase inhibitors

21 January 2018

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

21 January 2018

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BRAF targeted therapy changes the treatment paradigm in melanoma

21 January 2018

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New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

21 January 2018

1 reference

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

21 January 2018

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New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)

21 January 2018

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Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study

21 January 2018

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

21 January 2018

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

21 January 2018

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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

21 January 2018

1 reference

Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling

21 January 2018

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PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

21 January 2018

1 reference

21 January 2018

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Keratoacanthomas and squamous cell carcinomas in patients receiving sorafenib.

21 January 2018

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Prospective cost-effectiveness analysis of cetuximab in metastatic colorectal cancer: evaluation of National Cancer Institute of Canada Clinical Trials Group CO.17 trial.

21 January 2018

1 reference

American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy

21 January 2018

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Methodological and practical challenges for personalized cancer therapies

21 January 2018

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BRIM-2: An open-label, multicenter phase II study of vemurafenib in previously treated patients with BRAF V600E mutation-positive metastatic melanoma

21 January 2018

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Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oral MEK 1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oral BRAF inhibitor GSK2118436 (GSK436)

21 January 2018

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Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1345/APH.1Q363

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25 August 2017

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