(Q37959298)

25 August 2017

title

Inhibiting B-cell receptor signaling pathways in chronic lymphocytic leukemia (English)

1 reference

25 August 2017

0 references

1 reference

Jan A Burger

1

1 reference

25 August 2017

publication date

1 March 2012

1 reference

Current hematologic malignancy reports

25 August 2017

published in

1 reference

25 August 2017

volume

7

1 reference

25 August 2017

issue

1

1 reference

25 August 2017

page(s)

26-33

1 reference

https://scigraph.springernature.com/pub.10.1007/s11899-011-0104-z

25 August 2017

exact match

0 references

cites work

Chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

The microenvironment in mature B-cell malignancies: a target for new treatment strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkin's lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

The indispensable role of microenvironment in the natural history of low-grade B-cell neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Chronic lymphocytic leukemia: revelations from the B-cell receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Signal transduction pathways of mantle cell lymphoma: a phosphoproteome-based study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Oncogenic CARD11 mutations in human diffuse large B cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

B cell antigen receptor signaling: roles in cell development and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

B-cell antigen-receptor signalling in lymphocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Antigen receptors on B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Syk tyrosine kinase required for mouse viability and B-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Expression of Bruton's tyrosine kinase protein within the B cell lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Primary B cell immunodeficiencies: comparisons and contrasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

The B cell antigen receptor controls integrin activity through Btk and PLCgamma2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Roles for phosphoinositide 3-kinases, Bruton's tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

PI3 kinase signals BCR-dependent mature B cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

PI3K in lymphocyte development, differentiation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Bone marrow fibroblasts induce expression of PI3K/NF-kappaB pathway genes and a pro-angiogenic phenotype in CLL cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

CCL3 (MIP-1α) plasma levels and the risk for disease progression in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Comprehensive assessment of chemokine expression profiles by flow cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

CD38/CD31, the CCL3 and CCL4 chemokines, and CD49d/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Bruton's Tyrosine Kinase and Phospholipase Cγ2 Mediate Chemokine-Controlled B Cell Migration and Homing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Antigen receptor engagement selectively induces macrophage inflammatory protein-1 alpha (MIP-1 alpha) and MIP-1 beta chemokine production in human B cells.

21 January 2018

1 reference

12 December 2020

Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling

1 reference

12 December 2020

Non-malignant B cells and chronic lymphocytic leukemia cells induce a pro-survival phenotype in CD14+ cells from peripheral blood

1 reference

12 December 2020

Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkin's lymphoma

1 reference

12 December 2020

ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)

1 reference

12 December 2020

Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells.

1 reference

12 December 2020

Role of CCL3 protein (monocyte inflammatory protein-1 alpha) in lymphoid malignancy.

1 reference

12 December 2020

ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile

1 reference

12 December 2020

The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survival.

1 reference

12 December 2020

CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment

1 reference

12 December 2020

PI3K/p110{delta} is a novel therapeutic target in multiple myeloma

1 reference

12 December 2020

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

1 reference

12 December 2020

Survival of leukemic B cells promoted by engagement of the antigen receptor

1 reference

12 December 2020

10.1007/S11899-011-0104-Z

Identifiers

DOI

1 reference

25 August 2017

1 reference