(Q37962398)

26 August 2017

title

Iron metabolism in Nonalcoholic Fatty Liver Disease (English)

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metabolic dysfunction–associated steatotic liver disease

26 August 2017

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1 reference

3

Kris V Kowdley

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26 August 2017

James E Nelson

1

1 reference

26 August 2017

Heather Klintworth

series ordinal

2

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26 August 2017

publication date

1 February 2012

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Current gastroenterology reports

26 August 2017

published in

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26 August 2017

volume

14

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26 August 2017

issue

1

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26 August 2017

page(s)

8-16

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Human fatty liver disease: old questions and new insights

26 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Steatohepatitis: a tale of two "hits"?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Hepatic iron and nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Prevalence of the hemochromatosis gene mutation in patients with nonalcoholic steatohepatitis and correlation with degree of liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Pathology of hepatic iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Signaling role of iron in NF-kappa B activation in hepatic macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Iron regulation of hepatic macrophage TNFalpha expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

The molecular mechanism of hepcidin-mediated ferroportin down-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Regulation of hepcidin transcription by interleukin-1 and interleukin-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Interleukin-6 induces hepcidin expression through STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Mass spectrometry measurement of plasma hepcidin for the prediction of iron overload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Metals, oxidative stress, and hepatic fibrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Iron overload is associated with hepatic oxidative damage to DNA in nonalcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Regulation of cytokine signaling and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Mechanisms of hepatic fibrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Cross-talk between iron metabolism and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Characteristics of participants with self-reported hemochromatosis or iron overload at HEIRS study initial screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Pancreatic beta-cells express hepcidin, an iron-uptake regulatory peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Immunohistochemical findings in the pancreatic islets of a patient with transfusional iron overload and diabetes: case report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Transferrin and iron contribute to the lipolytic effect of serum in isolated adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Transferrin and iron induce insulin resistance of glucose transport in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Hyperinsulinaemia in non-cirrhotic haemochromatosis: impaired hepatic insulin degradation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Oxidative stress impairs insulin internalization in endothelial cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Hepatic iron loading in mice increases cholesterol biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Proteomic analysis of hepatic iron overload in mice suggests dysregulation of urea cycle, impairment of fatty acid oxidation, and changes in the methylation cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Iron overload alters glucose homeostasis, causes liver steatosis, and increases serum triacylglycerols in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Ferritins can regulate the secretion of apolipoprotein B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Iron as a co-morbid factor in nonhemochromatotic liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Beyond hereditary hemochromatosis: new insights into the relationship between iron overload and chronic liver diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Hyperferritinemia, iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Increased susceptibility to nonalcoholic fatty liver disease in heterozygotes for the mutation responsible for hereditary hemochromatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Lack of evidence for the pathogenic role of iron and HFE gene mutations in Brazilian patients with nonalcoholic steatohepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Clinical characteristics and prevalence of GB virus C, SEN virus, and HFE gene mutation in Japanese patients with nonalcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Serum ferritin is a clinical biomarker in Japanese patients with nonalcoholic steatohepatitis (NASH) independent of HFE gene mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Prevalence of HFE mutations and relation to serum iron status in patients with chronic hepatitis C and patients with nonalcoholic fatty liver disease in Taiwan

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Frequency of primary iron overload and HFE gene mutations (C282Y, H63D and S65C) in chronic liver disease patients in north India

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Nonalcoholic steatohepatitis in Asian Indians is neither associated with iron overload nor with HFE gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Iron-independent specific protein expression pattern in the liver of HFE-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Human carboxylesterase 1: from drug metabolism to drug discovery

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

21 January 2018

12 December 2020

Identification of fibrosis-relevant proteins using DIGE (difference in gel electrophoresis) in different models of hepatic fibrosis.

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Protein profiling of mouse livers with peroxisome proliferator-activated receptor alpha activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Combination treatment of angiotensin II type I receptor blocker and new oral iron chelator attenuates progression of nonalcoholic steatohepatitis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Effect of iron depletion in patients with nonalcoholic fatty liver disease without carbohydrate intolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Venesection for non-alcoholic fatty liver disease unresponsive to lifestyle counselling--a propensity score-adjusted observational study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-011-0234-4

Pathology of hepatic iron overload

21 January 2018

1 reference

12 December 2020

Nonalcoholic steatohepatitis: An expanded clinical entity

1 reference

12 December 2020

Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis

1 reference

12 December 2020

Pathways underlying iron accumulation in human nonalcoholic fatty liver disease

1 reference

12 December 2020

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

1 reference

12 December 2020

The penetrance of hemochromatosis: mice to the rescue

1 reference

12 December 2020

Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury

1 reference

12 December 2020

Effect of iron reduction by phlebotomy in Japanese patients with nonalcoholic steatohepatitis: A pilot study

1 reference

12 December 2020

Elevation of serum thioredoxin levels in patients with nonalcoholic steatohepatitis

1 reference

12 December 2020

Nonalcoholic fatty liver disease

1 reference

12 December 2020

The importance of iron and copper accumulation in the pathogenesis of non-alcoholic steatohepatitis

1 reference

12 December 2020

Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease

1 reference

12 December 2020

Effects of iron overload in a rat nutritional model of non-alcoholic fatty liver disease

1 reference

12 December 2020

Serum levels of hepcidin in patients with biopsy-proven nonalcoholic fatty liver disease.

1 reference

12 December 2020

Liver fibrosis and inflammation. A review.

1 reference

12 December 2020

HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity

1 reference

12 December 2020

Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis

1 reference

12 December 2020

Roles of oxidative stress in activation of Kupffer and Ito cells in liver fibrogenesis

1 reference

12 December 2020

Large amount of (apo)ferritin in the pancreatic insulin cell and its stimulation by glucose.

1 reference

12 December 2020

The wide spectrum of hepatic iron overload

1 reference

12 December 2020

The role of iron in nonalcoholic fatty liver disease: the story continues

1 reference

12 December 2020

An epidemiologic study on the incidence and significance of HFE mutations in a Korean cohort with nonalcoholic fatty liver disease

1 reference

12 December 2020

Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression

1 reference

12 December 2020

10.1007/S11894-011-0234-4

Identifiers

DOI

1 reference

26 August 2017

1 reference