(Q37973378)

26 August 2017

title

The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy (English)

1 reference

26 August 2017

Martin J Gunthorpe

1

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26 August 2017

Charles H Large

series ordinal

2

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26 August 2017

Raman Sankar

series ordinal

3

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26 August 2017

publication date

5 January 2012

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26 August 2017

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26 August 2017

volume

53

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26 August 2017

issue

3

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26 August 2017

page(s)

412-424

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Guide to Receptors and Channels (GRAC), 3rd edition

26 August 2017

cites work

1 reference

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Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by 4-aminopyridine in rat entorhinal cortex hippocampal slices

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Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by low magnesium in rat entorhinal cortex hippocampal slices.

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A potassium channel mutation in neonatal human epilepsy

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Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy.

21 January 2018

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Neural KCNQ (Kv7) channels

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A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family

21 January 2018

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Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains

21 January 2018

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KCNQ2 is a nodal K+ channel.

21 January 2018

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The anticonvulsant retigabine potently suppresses epileptiform discharges in the low Ca ++ and low Mg++ model in the hippocampal slice preparation.

21 January 2018

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Kv7/KCNQ/M and HCN/h, but not KCa2/SK channels, contribute to the somatic medium after-hyperpolarization and excitability control in CA1 hippocampal pyramidal cells.

21 January 2018

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KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.

21 January 2018

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21 January 2018

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21 January 2018

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Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity

21 January 2018

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Chromanol 293B binding in KCNQ1 (Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter

21 January 2018

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Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model.

21 January 2018

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Nervous system KV7 disorders: breakdown of a subthreshold brake

21 January 2018

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Antiepileptogenic and antiictogenic effects of retigabine under conditions of rapid kindling: an ontogenic study

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Molecular targets for antiepileptic drug development

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Effects of the anticonvulsant retigabine on cultured cortical neurons: changes in electroresponsive properties and synaptic transmission

21 January 2018

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A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon

21 January 2018

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The non-opioid analgesic flupirtine is a modulator of GABAA receptors involved in pain sensation

21 January 2018

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21 January 2018

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D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.

21 January 2018

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The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells

21 January 2018

1 reference

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The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits

21 January 2018

1 reference

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Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.

21 January 2018

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Molecular determinants of KCNQ1 channel block by a benzodiazepine

21 January 2018

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A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns

21 January 2018

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Phenytoin- and carbamazepine-resistant spontaneous bursting in rat entorhinal cortex is blocked by retigabine in vitro

21 January 2018

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Effects of retigabine on rhythmic synchronous activity of human neocortical slices

21 January 2018

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Towards a structural view of gating in potassium channels

21 January 2018

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Effect of the KCNQ potassium channel opener retigabine on single KCNQ2/3 channels expressed in CHO cells

21 January 2018

1 reference

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D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures

21 January 2018

1 reference

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Synergy between retigabine and GABA in modulating the convulsant site of the GABAA receptor complex

21 January 2018

1 reference

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A four-ligand hypercube model to quantify allosteric interactions within the GABAA receptor complex

21 January 2018

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GABAA receptor subtypes: any clues to the mechanism of benzodiazepine dependence?

21 January 2018

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Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability

21 January 2018

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Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells

21 January 2018

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The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03365.X

Expression profile and characterisation of a truncated KCNQ5 splice variant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03365.X

KCNQ/M channels control spike afterdepolarization and burst generation in hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03365.X

10.1111/J.1528-1167.2011.03365.X

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference