(Q37975546)

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Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development

scientific article published on February 2012

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

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ichthyotoxicity

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Adrian Hill

1

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Natalie Mesens

2

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Margino Steemans

3

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Jinghai James Xu

4

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Michael D Aleo

5

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Europe PubMed Central

PubMed publication ID

26 August 2017

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publication date

1 February 2012

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Europe PubMed Central

PubMed publication ID

26 August 2017

Drug Metabolism Reviews

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Europe PubMed Central

PubMed publication ID

26 August 2017

44

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Europe PubMed Central

PubMed publication ID

26 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

127-140

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Application of a high-content multiparameter cytotoxicity assay to prioritize compounds based on toxicity potential in humans

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Can in vitro metabolism-dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S-9 fraction

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Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systems

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Formation of the digestive system in zebrafish. I. Liver morphogenesis

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Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

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First dose of potential new medicines to humans: how animals help

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Influence of Matrigel-overlay on constitutive and inducible expression of nine genes encoding drug-metabolizing enzymes in primary human hepatocytes

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Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism

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Phase I and II enzyme characterization of two sources of HepG2 cell lines

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Efficient embedding technique for preparing small specimens for stereological volume estimation: zebrafish larvae.

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Zebrafish as a model vertebrate for investigating chemical toxicity

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The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development

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Which concentration of the inhibitor should be used to predict in vivo drug interactions from in vitro data?

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Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor

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Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human

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Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria

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Oxidative and conjugative xenobiotic metabolism in zebrafish larvae in vivo

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Idiosyncratic drug hepatotoxicity

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Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity.

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Microscale culture of human liver cells for drug development

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Recognizing drug-induced liver injury: current problems, possible solutions

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Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose

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Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens

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Identifiers

10.3109/03602532.2011.645578

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

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