(Q37975546)

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Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development

scientific article published on February 2012

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scholarly article

1 reference

Europe PubMed Central

26 August 2017

Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development (English)

1 reference

Europe PubMed Central

26 August 2017

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ichthyotoxicity

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based on heuristic

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author name string

Adrian Hill

1

1 reference

Europe PubMed Central

26 August 2017

Natalie Mesens

2

1 reference

Europe PubMed Central

26 August 2017

Margino Steemans

3

1 reference

Europe PubMed Central

26 August 2017

Jinghai James Xu

4

1 reference

Europe PubMed Central

26 August 2017

Michael D Aleo

5

1 reference

Europe PubMed Central

26 August 2017

language of work or name

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publication date

1 February 2012

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Europe PubMed Central

26 August 2017

Drug Metabolism Reviews

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Europe PubMed Central

26 August 2017

44

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Europe PubMed Central

26 August 2017

1

1 reference

Europe PubMed Central

26 August 2017

127-140

1 reference

Europe PubMed Central

26 August 2017

Application of a high-content multiparameter cytotoxicity assay to prioritize compounds based on toxicity potential in humans

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Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae.

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Strategies for the early detection of drug-induced hepatic steatosis in preclinical drug safety evaluation studies

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Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery.

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Can in vitro metabolism-dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S-9 fraction

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Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systems

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A novel actin isoform is expressed in the ovotestis of Aplysia californica

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Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation

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Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.

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Pharmacogenetics of the cytochromes P450.

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The price of innovation: new estimates of drug development costs

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Human variability in xenobiotic metabolism and pathway-related uncertainty factors for chemical risk assessment: a review

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Mechanisms controlling early development of the liver

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A predictive ligand-based Bayesian model for human drug-induced liver injury

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Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.

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Formation of the digestive system in zebrafish. I. Liver morphogenesis

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Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

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First dose of potential new medicines to humans: how animals help

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Developing structure-activity relationships for the prediction of hepatotoxicity.

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Influence of Matrigel-overlay on constitutive and inducible expression of nine genes encoding drug-metabolizing enzymes in primary human hepatocytes

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Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism

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Phase I and II enzyme characterization of two sources of HepG2 cell lines

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Efficient embedding technique for preparing small specimens for stereological volume estimation: zebrafish larvae.

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Zebrafish as a model vertebrate for investigating chemical toxicity

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The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development

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Which concentration of the inhibitor should be used to predict in vivo drug interactions from in vitro data?

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Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor

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Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human

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Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria

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Oxidative and conjugative xenobiotic metabolism in zebrafish larvae in vivo

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Idiosyncratic drug hepatotoxicity

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Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity.

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Microscale culture of human liver cells for drug development.

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A comparative study of genome-wide transcriptional profiles of primary hepatocytes in collagen sandwich and monolayer cultures

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Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge

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Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology

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Drug-induced hepatotoxicity.

1 reference

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Recognizing drug-induced liver injury: current problems, possible solutions

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Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2(+/-) mice: two-stage oxidative injury

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Quantitative expression profile of hepatobiliary transporters in sandwich cultured rat and human hepatocytes

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Zebrafish: a predictive model for assessing drug-induced toxicity

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Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening

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Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development

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Drug-related hepatotoxicity

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High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

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Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose

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From endoderm formation to liver and pancreas development in zebrafish

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Concordance of the toxicity of pharmaceuticals in humans and in animals

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High-throughput in vivo vertebrate screening

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Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens

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Zebrafish comparative genomics and the origins of vertebrate chromosomes

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Zebrafish assays for drug toxicity screening

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Drug hepatotoxicity from a regulatory perspective

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Role of the bile salt export pump, BSEP, in acquired forms of cholestasis

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Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.

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Constitutive and xenobiotics-induced expression of a novel CYP3A gene from zebrafish larva

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Role of metabolism in drug-induced idiosyncratic hepatotoxicity

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Zebrafish (Danio rerio) embryos as a model for testing proteratogens

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Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential

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Identifiers

10.3109/03602532.2011.645578

1 reference

Europe PubMed Central

26 August 2017

1 reference

Europe PubMed Central

26 August 2017

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