(Q37977364)

26 August 2017

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title

Mexiletine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in the treatment of arrhythmias (English)

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26 August 2017

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2

Brogden RN

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26 August 2017

Monk JP

1

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26 August 2017

publication date

1 September 1990

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26 August 2017

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26 August 2017

volume

40

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26 August 2017

issue

3

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26 August 2017

page(s)

374-411

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Mexiletine for ventricular arrhythmias

26 August 2017

cites work

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12 December 2020

Mexiletine action on the specialized tissues of the human heart

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12 December 2020

Evaluation of delayed-action preparations of mexiletine and dihydroquinidine in the treatment of ventricular extrasystolic arrhythmia

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12 December 2020

Mexiletine for control of drug-resistant ventricular tachycardia: Clinical and electrophysiologic results in 44 patients

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12 December 2020

Mexiletine in refractory ventricular arrhythmias

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12 December 2020

Chronic mexiletine therapy for suppression of ventricular arrhythmias.

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12 December 2020

Mexiletine, a new antiarrhythmic agent, for treatment of premature ventricular complexes

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12 December 2020

Efficacy of combination therapy with mexiletine and a type IA agent for inducible ventricular tachyarrhythmias secondary to coronary artery disease

1 reference

12 December 2020

Mexiletine: an effective antiarrhythmic drug for treatment of ventricular arrhythmias in congenital heart disease

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12 December 2020

Combined anti-arrhythmic therapy with class 1 and class 3 drugs

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12 December 2020

Comparative antiarrhythmic efficacy of verapamil, 17-monochloracetylajmaline, mexiletine and amiodarone in patients with severe chagasic myocarditis: relation with the underlying arrhythmogenic mechanisms

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12 December 2020

Comparative efficacy and safety of oral mexiletine and quinidine in benign or potentially lethal ventricular arrhythmias

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12 December 2020

Anti-arrhythmia effectiveness and tolerance of retard in comparison with standard mexiletine

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12 December 2020

Mexiletine and tocainide: a profile of two lidocaine analogs

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12 December 2020

Pseudothrombocytopenia and mexiletine.

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12 December 2020

Mexiletine: double-blind comparison with procainamide in PVC suppression and open-label sequential comparison with amiodarone in life-threatening ventricular arrhythmias.

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12 December 2020

Mexiletine in human blood and breast milk

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12 December 2020

Congestive heart failure induced by six of the newer antiarrhythmic drugs

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12 December 2020

The cellular electropharmacology of the simultaneous administration of propranolol and mexiletine: a class I and II antiarrhythmic drug combination

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12 December 2020

Mexiletine in the prophylaxis of ventricular arrhythmias during acute myocardial infarction

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12 December 2020

[Hemodynamic and electrophysiological effects of intravenous injection of mexiletine]

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12 December 2020

Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction

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12 December 2020

Oral mexiletine-theophylline interaction

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12 December 2020

Electropharmacologic synergism with mexiletine and quinidine.

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12 December 2020

Comparative Study of the Antiarrhythmic Efficacy of Mexiletine and Disopyramide in Patients with Chronic Ventricular Arrhythmias

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12 December 2020

Sodium current in freshly isolated and in cultured single rat myocardial cells: frequency and voltage-dependent block by mexiletine

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12 December 2020

Pharmacokinetics of oral mexiletine in patients with acute myocardial infarction

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12 December 2020

[Clinical electrophysiological evaluation of mexiletine]

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12 December 2020

Electrophysiologic testing of tocainide and mexiletine for ventricular tachycardia: assessment of the need to test both drugs

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12 December 2020

The effect of quinidine and other oral antiarrhythmic drugs on serum digoxin. A prospective study

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12 December 2020

Efficacy of mexiletine in chronic ventricular arrhythmias: a multicentre double-blind medium-term trial

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12 December 2020

Increase of mexiletine plasma levels due to delayed hepatic metabolism in patients with chronic liver disease

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12 December 2020

Mexiletine therapy of ventricular extrasystoles in the acute phase of myocardial infarction

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12 December 2020

Mexiletine removal by peritoneal dialysis

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12 December 2020

Mexiletine in acute myocardial infarction. Simulation of a theoretical protocol and validation in six patients

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12 December 2020

Haemodynamic effects of a new anti-arrhythmic agent, mexiletine (Ko 1173) in ischaemic heart disease

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12 December 2020

Observations of the haemodynamics of mexiletine

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12 December 2020

Mexiletine therapy in patients with chronic drug-resistant malignant ventricular arrhythmias. Clinical efficacy, safety, and side effects.

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12 December 2020

Comparative electropharmacology of mexiletine, lidocaine and quinidine in a canine Purkinje fiber model.

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12 December 2020

Kinetics and bioavailability of mexiletine in healthy subjects

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12 December 2020

Erythrocyte and serum distribution of mexiletine in man

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12 December 2020

Comparative Trial of Mexiletine and Lignocaine in the Treatment of Early Ventricular Tachyarrhythmias After Acute Myocardial Infarction

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12 December 2020

Efficacy of Mexiletine in the Medium-Term Treatment of Ventricular Arrhythmias. A Randomized, Double-Blind, Crossover Trial against Placebo in Ambulatory Patients

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12 December 2020

Oral mexiletine in the treatment of refractory ventricular arrhythmias: The role of electrophysiologic techniques

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12 December 2020

Combination antiarrhythmic therapy for management of malignant ventricular arrhythmia.

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12 December 2020

Relationship between plasma mexiletine levels at steady-state. Presence of ventricular arrhythmias and side effects.

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12 December 2020

Effects of simultaneous administration of mexiletine and quinidine on the electrophysiologic parameters of canine Purkinje fibers

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12 December 2020

Comparison of the inhibitory effects of mexiletine and lidocaine on the calcium current of single ventricular cells

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12 December 2020

Mexiletine. Long-term efficacy and side effects in patients with chronic drug-resistant potentially lethal ventricular arrhythmias.

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12 December 2020

Mexiletine for paroxysmal atrial fibrillation

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12 December 2020

Conversion from intravenous to oral mexiletine in the acute management of repetitive ventricular arrhythmia.

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12 December 2020

Mexiletine disposition: individual variation in response to urine acidification and alkalinisation

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12 December 2020

Changes in cardiac output determined by continuous-wave Doppler echocardiography during propafenone or mexiletine drug testing

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12 December 2020

Mexiletine for control of ventricular dysrhythmias in pregnancy

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12 December 2020

Discordance between ambulatory monitoring and programmed stimulation in assessing efficacy of mexiletine in patients with ventricular tachycardia

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12 December 2020

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12 December 2020

Anti-arrhythmic efficacy of the amiodarone-mexiletine combination in the treatment of resistant complex ventricular arrhythmias

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12 December 2020

Effect of cigarette smoking on mexiletine kinetics

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12 December 2020

Stereoselective serum protein binding of mexiletine enantiomers in man

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12 December 2020

Mexiletine and quinidine in ventricular ectopy

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12 December 2020

[Combination of sotalol with the class I B substances mexiletine or tocainide in complex ventricular extrasystole]

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12 December 2020

International Mexiletine and Placebo Antiarrhythmic Coronary Trial (IMPACT): II. Results from 24-hour electrocardiograms. IMPACT Research Group

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12 December 2020

[Comparative evaluation of mexiletine and propafenone by dynamic electrocardiography]

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12 December 2020

Effect of rifampicin treatment on the kinetics of mexiletine

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12 December 2020

A trial of intravenous and oral mexiletine in acute myocardial infarction

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12 December 2020

Pharmacokinetics and nondialyzability of mexiletine in renal failure

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12 December 2020

Mexiletine and quinidine in combination in an ischemic model: supra-additive antiarrhythmic and electrophysiologic actions

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12 December 2020

The distribution, metabolism and excretion of mexiletine in man

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12 December 2020

Mexiletine therapy in 15 patients with drug-resistant ventricular tachycardia.

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12 December 2020

Pharmacokinetic Drug Interactions with Theophylline

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12 December 2020

Hemodynamic repercussions and clinical tolerance of 6 class I anti-arrhythmia agents in acute myocardial infarction

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12 December 2020

Blockage of the sodium current in isolated single cells from rat ventricle with mexiletine and disopyramide.

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12 December 2020

Cirrhosis of the liver markedly impairs the elimination of mexiletine

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12 December 2020

Mexiletine-quinidine combination: electrophysiologic correlates of a favorable antiarrhythmic interaction in humans

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12 December 2020

Electrophysiologic effects and clinical efficacy of mexiletine used alone or in combination with class IA agents for refractory recurrent ventricular tachycardias or ventricular fibrillation

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12 December 2020

Mexiletine in the treatment of resistant ventricular arrhythmias: enhancement of efficacy and reduction of dose-related side effects by combination with quinidine

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12 December 2020

Pharmacokinetic interactions of cimetidine 1987.

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12 December 2020

Effects of age on the pharmacokinetics of mexiletine.

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12 December 2020

[Pharmacokinetics of mexiletine and its hydroxymethyl metabolite after intramuscular and intravenous administration of mexiletine in healthy subjects]

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12 December 2020

Mexiletine-theophylline interaction

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12 December 2020

[Hemodynamic effects of mexiletine and lidocaine in coronary surgery patients]

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12 December 2020

Low dose quinidine-mexiletine combination therapy versus quinidine monotherapy for treatment of ventricular arrhythmias

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12 December 2020

Frequency-dependent interactions of mexiletine and quinidine on depolarization and repolarization in canine Purkinje fibers

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12 December 2020

Long-term mexiletine for ventricular arrhythmia

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12 December 2020

Absorption, distribution and elimination of mexiletine

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12 December 2020

Treatment of arrhythmias with high risk of sudden death in chronic Chagas' cardiopathy with oral mexiletine. Evaluation with 24-hour ambulatory electrocardiographic monitoring (Holter)

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12 December 2020

Proarrhythmia related to a kinetic and dynamic interaction of mexiletine and theophylline

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12 December 2020

Long-term efficacy of mexiletine alone and in combination with class Ia antiarrhythmic drugs for refractory ventricular arrhythmias

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12 December 2020

Multiple comparison of several antiarrhythmic agents by acute oral drug testing in patients with chronic ventricular arrhythmias

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12 December 2020

Mexiletine in the management of ventricular dysrhythmias

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12 December 2020

[Effects of mexiletine in the Wolff-Parkinson-White syndrome]

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12 December 2020

Comparative trial of mexiletine and lignocaine in the treatment of ventricular arrhythmias.

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12 December 2020

Mexiletine kinetics in healthy subjects taking cimetidine

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12 December 2020

Long-term oral antiarrhythmic therapy with mexiletine

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12 December 2020

Effect of oral combination therapy with mexiletine and quinidine on left and right ventricular function

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12 December 2020

Interaction between mexiletine and digoxin

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12 December 2020

Prediction of efficacy and tolerance of oral mexiletine by intravenous lidocaine application.

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12 December 2020

Electrophysiological mechanisms for the antiarrhythmic action of mexiletine on digitalis-, reperfusion- and reoxygenation-induced arrhythmias

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12 December 2020

Reversible hepatic anomalies during treatment with mexiletine

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12 December 2020

Mexiletine use in pregnancy and lactation

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12 December 2020

Mexiletine for recurring ventricular arrhythmias: assessment by long-term electrocardiographic recordings and sequential electrophysiologic studies

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12 December 2020

Antiarrhythmic efficacy of penticainide and comparison with disopyramide, flecainide, propafenone and mexiletine by acute oral drug testing.

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12 December 2020

Dose independent pharmacokinetics of mexiletine in healthy volunteers

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12 December 2020

Absorption and antiarrhythmic efficacy of sustained-release mexiletine

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12 December 2020

[Mexiletine treatment of ventricular tachy-arrhythmias endangering life based on programmed ventricular stimulation]

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12 December 2020

Randomized controlled trial of prophylactic antiarrhythmic therapy in patients with inducible ventricular tachyarrhythmias after recent myocardial infarction

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12 December 2020

Usefulness and safety of cimetidine in patients receiving mexiletine for ventricular arrhythmia

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12 December 2020

Mexiletine clearance during peritoneal dialysis

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12 December 2020

Mexiletine: a review of its pharmacological properties and therapeutic efficacy in arrhythmias

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12 December 2020

Differential electrophysiologic effects of mexiletine on normal and hypoxic canine Purkinje fibers

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12 December 2020

Intolerance and ineffectiveness of mexiletine in patients with serious ventricular arrhythmias

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12 December 2020

The influence of urinary pH on the elimination of mexiletine

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12 December 2020

Efficacy of mexiletine in ventricular arrhythmias among patients in Taiwan: assessment by 24-hour Holter electrocardiography

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12 December 2020

Systolic time intervals in evaluation of the negative inotropic effect after single oral doses of mexiletine and disopyramide

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12 December 2020

Clinical study of the effectiveness of mexitil in the treatment of patients with extrasystole in old and advanced age

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12 December 2020

Propafenone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in the treatment of arrhythmias

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12 December 2020

Oral mexiletine in high-risk patients after myocardial infarction

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12 December 2020

Stereoselective disposition of mexiletine in man

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12 December 2020

Electrophysiological effects of mexiletine in man.

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12 December 2020

Recent developments in hepatic drug oxidation. Implications for clinical pharmacokinetics

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12 December 2020

Pharmacokinetics of intravenous mexiletine in patients with acute myocardial infarction

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12 December 2020

[Treatment of atrial fibrillation with mexiletine in Wolff-Parkinson-White syndrome]

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12 December 2020

Treatment of resistant supraventricular tachycardia with mexiletine

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12 December 2020

Pharmacokinetics and the antiarrhythmic effect of mexiletine in patients with chronic ventricular arrhythmias

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12 December 2020

Experimental studies on the antiarrhythmic mechanism of mexiletine in guinea pig ventricular muscles using microelectrode techniques

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12 December 2020

[Kinetics of mexiletine elimination in 7 healthy volunteers]

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12 December 2020

Effect of age on antiarrhythmic drug efficacy and toxicity

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12 December 2020

Comparative study of mexiletine and quinidine in the treatment of ventricular ectopia

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12 December 2020

A study to compare the efficacy, plasma concentration profile and tolerability of conventional mexiletine and slow-release mexiletine

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12 December 2020

Kinetics of oral and intravenous mexiletine: lack of effect of cimetidine and ranitidine

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12 December 2020

Treatment of recurrent sustained ventricular tachycardia with mexiletine and disopyramide. Control by programmed ventricular stimulation

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12 December 2020

Effectiveness of mexiletine in ventricular arrhythmias

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12 December 2020

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12 December 2020

Mexiletine: long-term efficacy and hemodynamic actions in patients with ventricular arrhythmia

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12 December 2020

The interaction of mexiletine with other cardiovascular drugs

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12 December 2020

Antiarrhythmic efficacy of combined intravenous and oral mexiletine in acute myocardial infarction. A double blind placebo-controlled study

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12 December 2020

Effects of oral mexiletine on left and right ventricular function

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12 December 2020

Comparison of intravenous mexiletine and lidocaine for the treatment of ventricular arrhythmias.

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12 December 2020

Electrophysiologic interactions between mexiletine and propafenone in guinea pig papillary muscles

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12 December 2020

The effects of mexiletine on cardiac arrhythmias in patients with cor pulmonale

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12 December 2020

Well-controlled comparative study of the clinical effectiveness of intravenous mexiletine and procainamide on ventricular premature contraction

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12 December 2020

Therapeutic effectiveness and plasma levels of single or combination use of class I antiarrhythmic agents for ventricular arrhythmias

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12 December 2020

[Pharmacokinetics and relative bioavailability of a new oral sustained-release form of mexiletine in healthy subjects]

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12 December 2020

Influence of mexiletine on caffeine elimination

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12 December 2020

Thrombocytopenia and mexiletine

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12 December 2020

Mexiletine for refractory-ventricular arrhythmias: results using serial electrophysiologic testing.

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12 December 2020

Potentiation of an anti-arrhythmia action by the combined use of mexiletine and propranolol

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12 December 2020

Haemodynamic studies on mexiletine, anew antiarrhythmic agent

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12 December 2020

International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings. Impact Research Group

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12 December 2020

[Injectable mexiletine and disorders of the auricular rhythm]

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12 December 2020

[Comparative studies on the cardiodepressant effect of disopyramide, mexiletine and propafenon]

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12 December 2020

Combination of disopyramide and mexiletine for better tolerance and additive effects for treatment of ventricular arrhythmias

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12 December 2020

Arrhythmogenic effects of mexiletine in infarcted Purkinje tissues

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12 December 2020

Mexiletine and tocainide: does response to one predict response to the other?

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12 December 2020

Efficacy of mexiletine in chronic ventricular arrhythmias compared with quinidine: A single-blind, randomized trial

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12 December 2020

Mexiletine for the treatment of ventricular arrhythmias associated with chronic obstructive pulmonary disease

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12 December 2020

Mexiletine-quinidine combination: enhanced antiarrhythmic and electrophysiologic activity in the dog

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12 December 2020

10.2165/00003495-199040030-00005

Identifiers

DOI

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Dimensions Publication ID

26 August 2017

1041592433

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