(Q37978254)

26 August 2017

title

Lead-oriented synthesis: a new opportunity for synthetic chemistry (English)

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26 August 2017

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Alan Nadin

1

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26 August 2017

Channa Hattotuwagama

series ordinal

2

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26 August 2017

Ian Churcher

series ordinal

3

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26 August 2017

language of work or name

English

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publication date

3 January 2012

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Angewandte Chemie International Edition

26 August 2017

published in

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volume

51

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26 August 2017

issue

5

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26 August 2017

page(s)

1114-1122

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Can the pharmaceutical industry reduce attrition rates?

26 August 2017

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Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity

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A comparison of physiochemical property profiles of development and marketed oral drugs

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A ‘Rule of Three’ for fragment-based lead discovery?

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Escape from flatland: increasing saturation as an approach to improving clinical success.

21 January 2018

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The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?

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21 January 2018

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Polymer-supported alpha-acylamino ketones: preparation and application in syntheses of 1,2,4-trisubstituted-1H-imidazoles

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Efficient and convenient synthesis of indazol-3(2H)-ones and 2-aminobenzonitriles

21 January 2018

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Multiplicity of diverse heterocycles from polymer-supported alpha-acylamino ketones

21 January 2018

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Rapid access to N-substituted diketopiperazines by one-pot Ugi-4CR/deprotection+activation/cyclization (UDAC).

21 January 2018

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Parallel microwave synthesis of 2-styrylquinazolin-4(3H)-ones in a high-throughput platform using HPLC/GC vials as reaction vessels.

21 January 2018

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The medicinal chemist's toolbox: an analysis of reactions used in the pursuit of drug candidates.

21 January 2018

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Factors determining the selection of organic reactions by medicinal chemists and the use of these reactions in arrays (small focused libraries).

21 January 2018

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Target-oriented and diversity-oriented organic synthesis in drug discovery

21 January 2018

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Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

21 January 2018

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Natural products as sources of new drugs over the last 25 years

21 January 2018

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Iridium-Catalyzed Asymmetric Allylic Amination with Polar Amines: Access to Building Blocks with Lead-Like Molecular Properties

21 January 2018

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Protecting-group-free synthesis as an opportunity for invention

21 January 2018

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Diversity-oriented synthesis and solid-phase organic synthesis under controlled microwave heating

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201105840

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26 August 2017

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