(Q37097848)

18 August 2017

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title

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? (English)

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18 August 2017

2

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18 August 2017

Paul D Dobson

1

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PubMed ID

18309312

18 August 2017

language of work or name

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1 March 2008

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Nature Reviews Drug Discovery

18 August 2017

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18 August 2017

7

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18 August 2017

3

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18 August 2017

205-220

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https://scigraph.springernature.com/pub.10.1038/nrd2438

18 August 2017

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cites work

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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Reconstitution of Cell Membrane Structure in vitro and its Transformation into an Excitable System

31 March 2020

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Permeability through DOPC/dodecane membranes: measurement and LFER modelling.

31 March 2020

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Review of theoretical passive drug absorption models: historical background, recent developments and limitations

31 March 2020

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Hydrogen bonding. 33. Factors that influence the distribution of solutes between blood and brain.

31 March 2020

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Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design

31 March 2020

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Determinants of benzodiazepine brain uptake: lipophilicity versus binding affinity.

31 March 2020

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On the mechanism of human intestinal absorption.

31 March 2020

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Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors.

31 March 2020

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Relationships between structure and high-throughput screening permeability of diverse drugs with artificial membranes: application to prediction of Caco-2 cell permeability

31 March 2020

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How lipids affect the activities of integral membrane proteins

31 March 2020

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Aggregation and vesiculation of membrane proteins by curvature-mediated interactions

31 March 2020

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Glycerol uptake in HCT-15 human colon cancer cell line by Na(+)-dependent carrier-mediated transport.

31 March 2020

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Osmotic stress signaling and osmoadaptation in yeasts

31 March 2020

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On the permeability to weak acids and bases of the cytoplasmic membrane of Clostridiumpasteurianum

31 March 2020

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Aquaporin water channels--from atomic structure to clinical medicine

31 March 2020

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Diffusion of Small Non-Electrolytes across Liposome Membranes

31 March 2020

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Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes

31 March 2020

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Comparison of drug transporter levels in normal colon, colon cancer, and Caco-2 cells: impact on drug disposition and discovery.

31 March 2020

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Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

31 March 2020

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Drug permeation in biomembranes: in vitro and in silico prediction and influence of physicochemical properties

31 March 2020

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Computational approaches for modeling human intestinal absorption and permeability.

31 March 2020

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Development and evaluation of an in vitro method for prediction of human drug absorption II. Demonstration of the method suitability.

31 March 2020

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Drug permeability across a phospholipid vesicle based barrier: a novel approach for studying passive diffusion.

31 March 2020

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Current industrial practices of assessing permeability and P-glycoprotein interaction

31 March 2020

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Solvent selection for whole cell biotransformations in organic media.

31 March 2020

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Predicting drug absorption: how nature made it a difficult problem.

31 March 2020

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

31 March 2020

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Histamine, theophylline and tryptamine transport through lipid bilayer membranes.

31 March 2020

1 reference

Biological Membranes behave as Non-porous Polymeric Sheets with Respect to the Diffusion of Non-electrolytes

31 March 2020

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The relationship between permeant size and permeability in lipid bilayer membranes

31 March 2020

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Permeability of Lipid Bilayer Membranes to Organic Solutes

31 March 2020

1 reference

Permeability of small nonelectrolytes through lipid bilayer membranes

31 March 2020

1 reference

Structural basis for the inhibition of firefly luciferase by a general anesthetic

31 March 2020

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The nature of sites of general anaesthetic action

31 March 2020

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Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

31 March 2020

1 reference

General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.

31 March 2020

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Anaesthetic drugs: linking molecular actions to clinical effects

31 March 2020

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Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513

31 March 2020

1 reference

Multidrug resistance pumps in bacteria: variations on a theme

31 March 2020

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Fungal ATP-binding cassette (ABC) transporters in drug resistance & detoxification

31 March 2020

1 reference

Mammalian ABC transporters in health and disease

31 March 2020

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Multiple molecular mechanisms for multidrug resistance transporters

31 March 2020

1 reference

The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction

31 March 2020

1 reference

Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates

31 March 2020

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Global reconstruction of the human metabolic network based on genomic and bibliomic data

31 March 2020

1 reference

Systematic identification of human mitochondrial disease genes through integrative genomics

31 March 2020

1 reference

The role and structure of mitochondrial carriers

31 March 2020

1 reference

The mitochondrial transporter family (SLC25): physiological and pathological implications

31 March 2020

1 reference

Mitochondrial carriers in the cytoplasmic state have a common substrate binding site

31 March 2020

1 reference

Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

31 March 2020

1 reference

The SLC22 drug transporter family

31 March 2020

1 reference

The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology

31 March 2020

1 reference

How to Make Drugs Orally Active: A Substrate Template for Peptide Transporter PepT1

31 March 2020

1 reference

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

31 March 2020

1 reference

Drugs for bad bugs: confronting the challenges of antibacterial discovery

31 March 2020

1 reference

A role for intra- and intercellular translocation in natural product biosynthesis

31 March 2020

1 reference

Quality, not quantity: the role of natural products and chemical proteomics in modern drug discovery

31 March 2020

1 reference

Pheromones, social behaviour and the functions of secondary metabolism in bacteria

31 March 2020

1 reference

The CATH domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution

31 March 2020

1 reference

Exploiting protein structure data to explore the evolution of protein function and biological complexity.

31 March 2020

1 reference

The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine.

31 March 2020

1 reference

Comparative analyses of fundamental differences in membrane transport capabilities in prokaryotes and eukaryotes

31 March 2020

1 reference

Pharmacogenomics of human OATP transporters

31 March 2020

1 reference

Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells

31 March 2020

1 reference

Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human

31 March 2020

1 reference

Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane.

31 March 2020

1 reference

A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

31 March 2020

1 reference

effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers

31 March 2020

1 reference

Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans

31 March 2020

1 reference

Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart

31 March 2020

1 reference

Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase

31 March 2020

1 reference

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) and genetic variability (single nucleotide polymorphisms) in a hepatic drug uptake transporter: what's it all about?

31 March 2020

1 reference

Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.

31 March 2020

1 reference

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

31 March 2020

1 reference

Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans

31 March 2020

1 reference

Transporter-mediated permeation of drugs across the blood-brain barrier

31 March 2020

1 reference

Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids.

31 March 2020

1 reference

Energy of an Ion crossing a Low Dielectric Membrane: Solutions to Four Relevant Electrostatic Problems

31 March 2020

1 reference

The Dielectric Constant of Phospholipid Bilayers and the Permeability of Membranes to Ions

31 March 2020

1 reference

Chemiosmotic coupling in oxidative and photosynthetic phosphorylation

31 March 2020

1 reference

Conversion of biomembrane-produced energy into electric form. I. Submitochondrial particles.

31 March 2020

1 reference

Delivery of drugs and macromolecules to mitochondria

31 March 2020

1 reference

Uptake of the lipophilic cation dibenzyldimethylammonium into Saccharomyces cerevisiae. Interaction with the thiamine transport system

31 March 2020

1 reference

Effect of a phenyl group in quaternary ammonium compounds on thiamine uptake in isolated rat hepatocytes

31 March 2020

1 reference

Thallous ion is accumulated by potassium transport systems in Escherichia coli

31 March 2020

1 reference

Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney

31 March 2020

1 reference

Drug transport proteins in the liver

31 March 2020

1 reference

Impact of drug transporter studies on drug discovery and development

31 March 2020

1 reference

Biochemical and molecular pharmacological aspects of transporters as determinants of drug disposition

31 March 2020

1 reference

Transporters and drug discovery: why, when, and how.

31 March 2020

1 reference

Tissue distribution and pharmacodynamics: a complicated relationship

31 March 2020

1 reference

Transporters as a determinant of drug clearance and tissue distribution

31 March 2020

1 reference

Scientific perspectives on drug transporters and their role in drug interactions

31 March 2020

1 reference

P-glycoprotein recognition of substrates and circumvention through rational drug design

31 March 2020

1 reference

Organic anion transporter (Slc22a) family members as mediators of toxicity

31 March 2020

1 reference

Transporter-mediated Drug Interactions

31 March 2020

1 reference

Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs

31 March 2020

1 reference

The role of transporters in drug interactions

31 March 2020

1 reference

Drug-drug interactions involving membrane transporters in the human kidney

31 March 2020

1 reference

Membrane localization and pH-dependent transport of a newly cloned organic cation transporter (PMAT) in kidney cells

31 March 2020

1 reference

Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

31 March 2020

1 reference

Absorption of peptide and peptidomimetic drugs

31 March 2020

1 reference

Tissue selective drug delivery utilizing carrier-mediated transport systems

31 March 2020

1 reference

Glutarimide: a carrier transporting drug through cell membranes.

31 March 2020

1 reference

Mammalian peptide transporters as targets for drug delivery

31 March 2020

1 reference

Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist

31 March 2020

1 reference

Lessons learned from marketed and investigational prodrugs

31 March 2020

1 reference

Membrane transporter/receptor-targeted prodrug design: strategies for human and veterinary drug development

31 March 2020

1 reference

Peptide transporters: structure, function, regulation and application for drug delivery

31 March 2020

1 reference

Molecular Trojan horses for blood-brain barrier drug delivery

31 March 2020

1 reference

Intestinal absorption of peptide drugs: advances in our understanding and clinical implications

31 March 2020

1 reference

Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1.

31 March 2020

1 reference

Conformational and spacial preferences for substrates of PepT1

31 March 2020

1 reference

A new class of synthetic antibacterials acting on lipopolysaccharide biosynthesis

31 March 2020

1 reference

Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas

31 March 2020

1 reference

Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cells.

31 March 2020

1 reference

Increased acyclovir oral bioavailability via a bile acid conjugate

31 March 2020

1 reference

Role of the monocarboxylic acid transport system in the intestinal absorption of an orally active beta-lactam prodrug: carindacillin as a model.

31 March 2020

1 reference

Nonleadlikeness and leadlikeness in biochemical screening

31 March 2020

1 reference

Pursuing the leadlikeness concept in pharmaceutical research.

31 March 2020

1 reference

Prediction of 'drug-likeness'.

31 March 2020

1 reference

Selection criteria for drug-like compounds

31 March 2020

1 reference

Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits

31 March 2020

1 reference

The role of blood-brain barrier studies in the pharmaceutical industry

31 March 2020

1 reference

The influence of drug-like concepts on decision-making in medicinal chemistry

31 March 2020

1 reference

Novel cationic and neutral glycocholic acid and polyamine conjugates able to inhibit transporters involved in hepatic and intestinal bile acid uptake.

31 March 2020

1 reference

Neurotransmitter transporters: molecular function of important drug targets

31 March 2020

1 reference

Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs).

31 March 2020

1 reference

Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter

31 March 2020

1 reference

Cloning and functional expression of a human liver organic cation transporter

31 March 2020

1 reference

Knocking down transport: applications of RNA interference in the study of drug transport proteins

31 March 2020

1 reference

Organic anion transporter family: current knowledge.

31 March 2020

1 reference

The transport of organic cations in the small intestine: current knowledge and emerging concepts

31 March 2020

1 reference

A gene atlas of the mouse and human protein-encoding transcriptomes

31 March 2020

1 reference

An atlas of human gene expression from massively parallel signature sequencing (MPSS).

31 March 2020

1 reference

A human protein atlas for normal and cancer tissues based on antibody proteomics

31 March 2020

1 reference

Towards a human proteome atlas: High-throughput generation of mono-specific antibodies for tissue profiling

31 March 2020

1 reference

Systems-ADME/Tox: resources and network approaches

31 March 2020

1 reference

In vitro and pharmacophore insights into CYP3A enzymes

31 March 2020

1 reference

Theodor Bücher Lecture. Metabolomics, modelling and machine learning in systems biology - towards an understanding of the languages of cells. Delivered on 3 July 2005 at the 30th FEBS Congress and the 9th IUBMB conference in Budapest.

31 March 2020

1 reference

The model organism as a system: integrating 'omics' data sets

31 March 2020

1 reference

Finding function in novel targets: C. elegans as a model organism.

31 March 2020

1 reference

A chemical genomics approach to understanding drug action

31 March 2020

1 reference

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes

31 March 2020

1 reference

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

31 March 2020

1 reference

Yeast-based functional genomics and proteomics technologies: the first 15 years and beyond.

31 March 2020

1 reference

Target identification strategies in chemical genetics

31 March 2020

1 reference

Genetic and genomic approaches to identify and study the targets of bioactive small molecules.

31 March 2020

1 reference

The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models

31 March 2020

1 reference

Systems biology, metabolic modelling and metabolomics in drug discovery and development

31 March 2020

1 reference

The virtual human: towards a global systems biology of multiscale, distributed biochemical network models

31 March 2020

1 reference

The cell biology of the blood-brain barrier.

31 March 2020

1 reference

High throughput artificial membrane permeability assay for blood-brain barrier.

31 March 2020

1 reference

Transport of glutamate and other amino acids at the blood-brain barrier

31 March 2020

1 reference

Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications

31 March 2020

1 reference

Carrier-mediated processes in blood--brain barrier penetration and neural uptake of paraquat

31 March 2020

1 reference

New approaches to in vitro models of blood-brain barrier drug transport.

31 March 2020

1 reference

Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry

31 March 2020

1 reference

Molecular modeling of blood-brain barrier nutrient transporters: in silico basis for evaluation of potential drug delivery to the central nervous system

31 March 2020

1 reference

Drug efflux transporters in the CNS.

31 March 2020

1 reference

ABC transporters and the blood-brain barrier

31 March 2020

1 reference

Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain.

31 March 2020

1 reference

In vitro prediction of brain penetration - a case for free thinking?

31 March 2020

1 reference

Central nervous system drug disposition: the relationship between in situ brain permeability and brain free fraction

31 March 2020

1 reference

Blood-brain barrier delivery

31 March 2020

1 reference

Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines

31 March 2020

1 reference

Identification of the cationic amino acid transporter (System y+) of the rat blood-brain barrier.

31 March 2020

1 reference

Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain

31 March 2020

1 reference

Cloning and functional expression of a brain peptide/histidine transporter

31 March 2020

1 reference

Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor.

31 March 2020

1 reference

Development of a P-glycoprotein knockout model in rodents to define species differences in its functional effect at the blood-brain barrier

31 March 2020

1 reference

Transporter-mediated drug delivery: recent progress and experimental approaches

31 March 2020

1 reference

Building an abbreviation dictionary using a term recognition approach

31 March 2020

1 reference

Genew: the Human Gene Nomenclature Database, 2004 updates

31 March 2020

1 reference

TCDB: the Transporter Classification Database for membrane transport protein analyses and information

31 March 2020

1 reference

A genomic view of yeast membrane transporters

31 March 2020

1 reference

Transporter database, TP-Search: a web-accessible comprehensive database for research in pharmacokinetics of drugs

31 March 2020

1 reference

TransportDB: a relational database of cellular membrane transport systems

31 March 2020

1 reference

Functional expression of stereoselective metabolism of cephalexin by exogenous transfection of oligopeptide transporter PEPT1.

31 March 2020

1 reference

Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1.

31 March 2020

1 reference

Molecular cloning and tissue distribution of rat peptide transporter PEPT2.

31 March 2020

1 reference

Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters

31 March 2020

1 reference

Transporters involved in apical and basolateral uptake of ceftibuten into Caco-2 cells

31 March 2020

1 reference

Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives.

31 March 2020

1 reference

Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir.

31 March 2020

1 reference

Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2.

31 March 2020

1 reference

Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice

31 March 2020

1 reference

Human organic anion transporters and human organic cation transporters mediate renal antiviral transport

31 March 2020

1 reference

Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin

31 March 2020

1 reference

Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine

31 March 2020

1 reference

Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.

31 March 2020

1 reference

The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers

31 March 2020

1 reference

cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney

31 March 2020

1 reference

Cloning and characterization of two human polyspecific organic cation transporters

31 March 2020

1 reference

Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter

31 March 2020

1 reference

beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter

31 March 2020

1 reference

Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1.

31 March 2020

1 reference

Expression cloning and characterization of a novel multispecific organic anion transporter

31 March 2020

1 reference

Transport of cimetidine by flounder and human renal organic anion transporter 1.

31 March 2020

1 reference

Human organic anion transporters mediate the transport of tetracycline

31 March 2020

1 reference

Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics.

31 March 2020

1 reference

Identification of multispecific organic anion transporter 2 expressed predominantly in the liver

31 March 2020

1 reference

Isolation of a family of organic anion transporters from human liver and kidney

31 March 2020

1 reference

Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver

31 March 2020

1 reference

The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein.

31 March 2020

1 reference

Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family

31 March 2020

1 reference

Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver

31 March 2020

1 reference

Hepatic uptake of the novel antifungal agent caspofungin

31 March 2020

1 reference

LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.

31 March 2020

1 reference

Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells

31 March 2020

1 reference

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

31 March 2020

1 reference

Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans

31 March 2020

1 reference

Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B.

31 March 2020

1 reference

Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

31 March 2020

1 reference

Tissue distribution and ontogeny of organic cation transporters in mice

31 March 2020

1 reference

7 January 2021

The Edinburgh human metabolic network reconstruction and its functional analysis

1 reference

7 January 2021

Comparison of drug efflux transport kinetics in various blood-brain barrier models

1 reference

7 January 2021

Selective substrates for non-neuronal monoamine transporters

1 reference

7 January 2021

Identifiers

DOI

10.1038/NRD2438

1 reference

PubMed ID

18309312

Dimensions Publication ID

18 August 2017

0 references

1 reference

PubMed ID

18309312