(Q36439145)

14 August 2017

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title

Current industrial practices of assessing permeability and P-glycoprotein interaction (English)

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14 August 2017

Praveen V Balimane

1

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14 August 2017

Yong-Hae Han

series ordinal

2

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14 August 2017

Saeho Chong

series ordinal

3

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14 August 2017

language of work or name

English

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publication date

13 January 2006

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14 August 2017

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14 August 2017

8

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14 August 2017

1

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14 August 2017

E1-13

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https://scigraph.springernature.com/pub.10.1208/aapsj080101

14 August 2017

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cites work

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Can the pharmaceutical industry reduce attrition rates?

30 September 2017

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Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin

30 September 2017

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Intestinal membrane transport of drugs and nutrients: genomics of membrane transporters using expression microarrays

30 September 2017

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Rapid assessment of P-glycoprotein inhibition and induction in vitro

30 September 2017

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Enhanced exposure of phosphatidylserine in human gastric carcinoma cells overexpressing the half-size ABC transporter BCRP (ABCG2).

30 September 2017

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Biological, pharmaceutical, and analytical considerations with respect to the transport media used in the absorption screening system, Caco-2.

30 September 2017

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Role of P-glycoprotein in pharmacokinetics: clinical implications

30 September 2017

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Physicochemical profiling (solubility, permeability and charge state).

30 September 2017

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Assessing the absorption of new pharmaceuticals

30 September 2017

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High throughput physicochemical profiling for drug discovery

30 September 2017

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Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Current methodologies used for evaluation of intestinal permeability and absorption

30 September 2017

1 reference

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

30 September 2017

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In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results

30 September 2017

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Cell cultures as tools in biopharmacy.

30 September 2017

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Fexofenadine: a review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticaria

30 September 2017

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Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter

30 September 2017

1 reference

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Flux measurements across Caco-2 monolayers may predict transport in human large intestinal tissue

30 September 2017

1 reference

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In vitro systems for studying intestinal drug absorption

30 September 2017

1 reference

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Cell cultures as models for drug absorption across the intestinal mucosa

30 September 2017

1 reference

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Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Rational use of in vitro P-glycoprotein assays in drug discovery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Upper gastrointestinal pH in seventy-nine healthy, elderly, North American men and women.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Upper gastrointestinal (GI) pH in young, healthy men and women.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. Possible roles of P-glycoprotein in biliary excretion of vincristine

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Caco-2 replace or refine?

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

A combined cell based approach to identify P-glycoprotein substrates and inhibitors in a single assay

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

PAMPA--a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKa(flux)--optimized design (pOD-PAMPA).

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

High throughput artificial membrane permeability assay for blood-brain barrier.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Drug-drug interaction mediated by inhibition and induction of P-glycoprotein.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Effect of bovine serum albumin on drug permeability estimation across Caco-2 monolayers

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Effect of common excipients on Caco-2 transport of low-permeability drugs

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Permeability of lipophilic compounds in drug discovery using in-vitro human absorption model, Caco-2.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751418

Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery

21 September 2018

1 reference

12 December 2020

In vitro permeability through caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system

1 reference

12 December 2020

Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs

1 reference

12 December 2020

Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter.

1 reference

12 December 2020

The influence of donor and reservoir additives on Caco-2 permeability and secretory transport of HIV protease inhibitors and other lipophilic compounds

1 reference

12 December 2020

Effects of some non-ionic surfactants on transepithelial permeability in Caco-2 cells

1 reference

12 December 2020

Relationships between structure and high-throughput screening permeability of peptide derivatives and related compounds with artificial membranes: application to prediction of Caco-2 cell permeability

1 reference

12 December 2020

Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes

1 reference

12 December 2020

Identifiers

DOI

10.1208/AAPSJ080101

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Dimensions Publication ID

14 August 2017

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14 August 2017

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