(Q37978548)

26 August 2017

The role of clusterin in Alzheimer's disease: pathways, pathogenesis, and therapy (English)

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26 August 2017

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1

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26 August 2017

2

Lan Tan

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26 August 2017

25 January 2012

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26 August 2017

Molecular Neurobiology

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26 August 2017

45

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26 August 2017

2

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26 August 2017

314-326

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https://scigraph.springernature.com/pub.10.1007/s12035-012-8237-1

26 August 2017

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cites work

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Plasma clusterin and the risk of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Chapter 2: Clusterin (CLU): From one gene and two transcripts to many proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Apolipoprotein J: structure and tissue distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Clusterin: a forgotten player in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Biosynthesis and molecular cloning of sulfated glycoprotein 2 secreted by rat Sertoli cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Meta-analysis of linkage studies for Alzheimer's disease--a web resource

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Genome-wide analysis of genetic loci associated with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Replication of CLU, CR1, and PICALM associations with alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Implication of CLU gene polymorphisms in Chinese patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Genetic variability in CLU and its association with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Alzheimer's risk variants in the clusterin gene are associated with alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Epigenetic regulation in the pathophysiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Clusterin is epigenetically regulated in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Induction of clusterin/apoJ expression by histone deacetylase inhibitors in neural cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

The role of epigenetics in aging and age-related diseases

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Age-specific epigenetic drift in late-onset Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

The environment, epigenetics and amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Multiple roles of HDAC inhibition in neurodegenerative conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Histone deacetylase inhibitors: Potential in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Clusterin (apolipoprotein J) protein levels are increased in hippocampus and in frontal cortex in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Structural and quantitative comparison of cerebrospinal fluid glycoproteins in Alzheimer's disease patients and healthy individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Serum clusterin levels are not increased in presymptomatic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Clusterin/apolipoprotein J in human aging and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Apolipoprotein J and Alzheimer's amyloid beta solubility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Role of ischemic blood-brain barrier on amyloid plaques development in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Functional and structural properties of lipid-associated apolipoprotein J (clusterin).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese females

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Glia and their cytokines in progression of neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Chapter 8: Clusterin: A multifacet protein at the crossroad of inflammation and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Identification of clusterin domain involved in NF-kappaB pathway regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Regulation of clusterin gene expression by transforming growth factor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Essential requirement of apolipoprotein J (clusterin) signaling for IkappaB expression and regulation of NF-kappaB activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Clusterin expression by astrocytes is influenced by transforming growth factor beta 1 and heterotypic cell interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Clusterin isoforms differentially affect growth and motility of prostate cells: possible implications in prostate tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Modulation of different clusterin isoforms in human colon tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Overexpression of the cytoprotective protein clusterin decreases radiosensitivity in the human LNCaP prostate tumour model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

An oral apoJ peptide renders HDL antiinflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Clusterin in Alzheimer's disease

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

21 January 2018

12 December 2020

Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Beneficial effects of r-h-CLU on disease severity in different animal models of peripheral neuropathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8237-1

Apolipoprotein E receptors mediate the effects of beta-amyloid on astrocyte cultures

21 January 2018

1 reference

12 December 2020

Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis

1 reference

12 December 2020

In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

1 reference

12 December 2020

Laminar shear stress upregulates the complement-inhibitory protein clusterin : a novel potent defense mechanism against complement-induced endothelial cell activation

1 reference

12 December 2020

Predominant apolipoprotein J exists as lipid-poor mixtures in cerebrospinal fluid

1 reference

12 December 2020

Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.

1 reference

12 December 2020

Distribution and synthesis of apolipoprotein J in the atherosclerotic aorta

1 reference

12 December 2020

Immunolocalization of cubilin, megalin, apolipoprotein J, and apolipoprotein A-I in the uterus and oviduct

1 reference

12 December 2020

Apolipoprotein J (clusterin) and Alzheimer's disease

1 reference

12 December 2020

Blood clusterin levels, rs9331888 polymorphism, and the risk of Alzheimer's disease.

1 reference

12 December 2020

SP-40,40, a protein involved in the control of the complement pathway, possesses a unique array of disulphide bridges

1 reference

12 December 2020

Brain expression of apolipoproteins E, J, and A-I in Alzheimer's disease

1 reference

12 December 2020

Amyloid-beta 1-42 induced endocytosis and clusterin/apoJ protein accumulation in cultured human astrocytes

1 reference

12 December 2020

Association of CLU and PICALM variants with Alzheimer's disease.

1 reference

12 December 2020

Identification of Epigenetically Silenced Genes in Tumor Endothelial Cells

1 reference

12 December 2020

10.1007/S12035-012-8237-1

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22274961