(Q37981890)

26 August 2017

Human genetic susceptibility to infectious disease (English)

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26 August 2017

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2

Adrian V S Hill

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26 August 2017

Stephen J Chapman

1

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26 August 2017

7 February 2012

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26 August 2017

Nature Reviews Genetics

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26 August 2017

13

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26 August 2017

3

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26 August 2017

175-188

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https://scigraph.springernature.com/pub.10.1038/nrg3114

26 August 2017

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cites work

Robert Koch, the Nobel Prize, and the ongoing threat of tuberculosis

1 reference

Leprosy and the human genome

31 March 2020

1 reference

Heredity versus environment in tuberculosis in twins: the 1950s United Kingdom Prophit Survey Simonds and Comstock revisited.

31 March 2020

1 reference

Genetic and environmental influences on premature death in adult adoptees

31 March 2020

1 reference

Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains

31 March 2020

1 reference

Genetics of susceptibility to human infectious disease

31 March 2020

1 reference

Aspects of genetic susceptibility to human infectious diseases

31 March 2020

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Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better?

31 March 2020

1 reference

Genetic epidemiology of tuberculosis susceptibility: impact of study design

31 March 2020

1 reference

Host genes associated with HIV/AIDS: advances in gene discovery

31 March 2020

1 reference

Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis

31 March 2020

1 reference

Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis

31 March 2020

1 reference

A haplotype map of the human genome

31 March 2020

1 reference

A second generation human haplotype map of over 3.1 million SNPs

31 March 2020

1 reference

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

31 March 2020

1 reference

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

31 March 2020

1 reference

Genomewide association studies and assessment of the risk of disease

31 March 2020

1 reference

Variation across the allele frequency spectrum

31 March 2020

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Genetic heterogeneity in human disease

31 March 2020

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Uncovering the roles of rare variants in common disease through whole-genome sequencing

31 March 2020

1 reference

Genetic risk prediction--are we there yet?

31 March 2020

1 reference

Host genetics and HIV-1: the final phase?

31 March 2020

1 reference

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

31 March 2020

1 reference

Genetic acceleration of AIDS progression by a promoter variant of CCR5.

31 March 2020

1 reference

Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression

31 March 2020

1 reference

The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.

31 March 2020

1 reference

Associations of MHC ancestral haplotypes with resistance/susceptibility to AIDS disease development.

31 March 2020

1 reference

KIR-HLA intercourse in HIV disease

31 March 2020

1 reference

Common genetic variation and the control of HIV-1 in humans

31 March 2020

1 reference

A whole-genome association study of major determinants for host control of HIV-1

31 March 2020

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The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

31 March 2020

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Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population

31 March 2020

1 reference

A whole genome association study of mother-to-child transmission of HIV in Malawi

31 March 2020

1 reference

Host determinants of HIV-1 control in African Americans

31 March 2020

1 reference

Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study

31 March 2020

1 reference

Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS.

31 March 2020

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Genome-wide association study implicates PARD3B-based AIDS restriction

31 March 2020

1 reference

Genomewide Association Study of an AIDS‐Nonprogression Cohort Emphasizes the Role Played byHLAGenes (ANRS Genomewide Association Study 02)

31 March 2020

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Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS.

31 March 2020

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Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).

31 March 2020

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Association between CCR5 genotype and the clinical course of HIV-1 infection

31 March 2020

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Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

31 March 2020

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Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

31 March 2020

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CCR5 promoter polymorphism determines macrophage CCR5 density and magnitude of HIV-1 propagation in vitro

31 March 2020

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CCR2 Polymorphism and HIV Disease

31 March 2020

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Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

31 March 2020

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HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.

31 March 2020

1 reference

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

31 March 2020

1 reference

Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study

31 March 2020

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IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy

31 March 2020

1 reference

Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C

31 March 2020

1 reference

IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations.

31 March 2020

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Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

31 March 2020

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Interferon-alfa, interferon-lambda and hepatitis C.

31 March 2020

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Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics

31 March 2020

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A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.

31 March 2020

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A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese.

31 March 2020

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Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population

31 March 2020

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Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies

31 March 2020

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Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver

31 March 2020

1 reference

Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1

31 March 2020

1 reference

Effect of NKG2D ligand expression on host immune responses

31 March 2020

1 reference

The early whole-blood transcriptional signature of dengue virus and features associated with progression to dengue shock syndrome in Vietnamese children and young adults

31 March 2020

1 reference

Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible

31 March 2020

1 reference

A global network for investigating the genomic epidemiology of malaria

31 March 2020

1 reference

Genome-wide and fine-resolution association analysis of malaria in West Africa

31 March 2020

1 reference

Protection afforded by sickle-cell trait against subtertian malareal infection

31 March 2020

1 reference

Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

31 March 2020

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Susceptibility to leprosy is associated with PARK2 and PACRG.

31 March 2020

1 reference

Stepwise replication identifies a low-producing lymphotoxin-α allele as a major risk factor for early-onset leprosy

31 March 2020

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HLA and leprosy in the pre and postgenomic eras

31 March 2020

1 reference

Genomewide association study of leprosy

31 March 2020

1 reference

A common genetic fingerprint in leprosy and Crohn's disease?

31 March 2020

1 reference

Leprosy and the adaptation of human toll-like receptor 1.

31 March 2020

1 reference

Genomewide association study of leprosy

31 March 2020

1 reference

Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states

31 March 2020

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Intracellular NOD-like receptors in host defense and disease

31 March 2020

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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

31 March 2020

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Crohn's disease: an immune deficiency state

31 March 2020

1 reference

Factor H, a regulator of complement activity, is a major determinant of meningococcal disease susceptibility in UK Caucasian patients.

31 March 2020

1 reference

Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease

31 March 2020

1 reference

A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration

31 March 2020

1 reference

Disease-causing mutations in genes of the complement system

31 March 2020

1 reference

Codon 129 genotype and new variant CJD

31 March 2020

1 reference

Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics

31 March 2020

1 reference

Sporadic and familial CJD: classification and characterisation.

31 March 2020

1 reference

Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study

31 March 2020

1 reference

Variant CJD in an individual heterozygous for PRNP codon 129

31 March 2020

1 reference

Primary immunodeficiencies: a field in its infancy

31 March 2020

1 reference

Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency

31 March 2020

1 reference

Genetic deficiencies of innate immune signalling in human infectious disease

31 March 2020

1 reference

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

31 March 2020

1 reference

Pyogenic bacterial infections in humans with MyD88 deficiency

31 March 2020

1 reference

A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO)

31 March 2020

1 reference

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling

31 March 2020

1 reference

Pyogenic bacterial infections in humans with IRAK-4 deficiency

31 March 2020

1 reference

A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency

31 March 2020

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The same IkappaBalpha mutation in two related individuals leads to completely different clinical syndromes.

31 March 2020

1 reference

Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections

31 March 2020

1 reference

Toll-like receptor polymorphisms and susceptibility to human disease

31 March 2020

1 reference

IkappaB genetic polymorphisms and invasive pneumococcal disease

31 March 2020

1 reference

NFKBIZ polymorphisms and susceptibility to pneumococcal disease in European and African populations

31 March 2020

1 reference

Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study

31 March 2020

1 reference

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

31 March 2020

1 reference

Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts

31 March 2020

1 reference

Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy

31 March 2020

1 reference

Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations

31 March 2020

1 reference

A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis

31 March 2020

1 reference

TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus.

31 March 2020

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Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups

31 March 2020

1 reference

Toll-like receptor and TIRAP gene polymorphisms in pulmonary tuberculosis patients of South India.

31 March 2020

1 reference

Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive haemophilus influenzae serotype b infection in immunized children.

31 March 2020

1 reference

Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock

31 March 2020

1 reference

Herpes simplex virus encephalitis in human UNC-93B deficiency

31 March 2020

1 reference

TLR3 deficiency in patients with herpes simplex encephalitis

31 March 2020

1 reference

Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis

31 March 2020

1 reference

HLA and infectious diseases

31 March 2020

1 reference

Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility

31 March 2020

1 reference

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

31 March 2020

1 reference

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

31 March 2020

1 reference

Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency

31 March 2020

1 reference

Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

31 March 2020

1 reference

STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis

31 March 2020

1 reference

STAT3 mutations in the hyper-IgE syndrome

31 March 2020

1 reference

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

31 March 2020

1 reference

Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity

31 March 2020

1 reference

CISH and susceptibility to infectious diseases

31 March 2020

1 reference

Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease

31 March 2020

1 reference

Human genetics of infectious diseases: between proof of principle and paradigm

31 March 2020

1 reference

Human genetic variation and its contribution to complex traits

31 March 2020

1 reference

Methodological challenges of genome-wide association analysis in Africa

31 March 2020

1 reference

Genome-wide association studies in diverse populations

31 March 2020

1 reference

A map of human genome variation from population-scale sequencing

31 March 2020

1 reference

Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense

31 March 2020

1 reference

Immunological and genetic bases of new primary immunodeficiencies

31 March 2020

1 reference

Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis

31 March 2020

1 reference

Human genetic susceptibility to intracellular pathogens

31 March 2020

1 reference

IFNG +874T/A, IL10 -1082G/A and TNF -308G/A polymorphisms in association with tuberculosis susceptibility: a meta-analysis study

31 March 2020

1 reference

No association between interferon-gamma receptor-1 gene polymorphism and pulmonary tuberculosis in a Gambian population sample

31 March 2020

1 reference

Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease

31 March 2020

1 reference

IRF8 mutations and human dendritic-cell immunodeficiency

31 March 2020

1 reference

Mendelian resistance to human norovirus infections

31 March 2020

1 reference

Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin

31 March 2020

1 reference

Mechanisms of GII.4 norovirus persistence in human populations

31 March 2020

1 reference

Variable host-pathogen compatibility in Mycobacterium tuberculosis

31 March 2020

1 reference

Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis.

31 March 2020

1 reference

Joint effects of host genetic background and mycobacterial pathogen on susceptibility to infection

31 March 2020

1 reference

The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis

31 March 2020

1 reference

31 March 2020

On the Origin of Leprosy

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Is susceptibility to tuberculosis acquired or inherited?

31 March 2020

1 reference

Genetic basis of natural variation in D. melanogaster antibacterial immunity.

31 March 2020

1 reference

Mortality in HIV infection is independently predicted by host iron status and SLC11A1 and HP genotypes, with new evidence of a gene-nutrient interaction

31 March 2020

1 reference

Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

31 March 2020

1 reference

Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant

31 March 2020

1 reference

First large, multicenter, open-label study utilizing HLA-B*5701 screening for abacavir hypersensitivity in North America

31 March 2020

1 reference

The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir

31 March 2020

1 reference

Genetic variations in HLA-B region and hypersensitivity reactions to abacavir

31 March 2020

1 reference

IL28B genomic-based treatment paradigms for patients with chronic hepatitis C infection: the future of personalized HCV therapies

31 March 2020

1 reference

ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C.

31 March 2020

1 reference

ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients.

31 March 2020

1 reference

Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C

31 March 2020

1 reference

The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals

31 March 2020

1 reference

Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections

31 March 2020

1 reference

Assessment of complement deficiency in patients with meningococcal disease in The Netherlands

31 March 2020

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Complement deficiency states and associated infections

31 March 2020

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Hereditary C2 deficiency in Sweden: frequent occurrence of invasive infection, atherosclerosis, and rheumatic disease

31 March 2020

1 reference

Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma

31 March 2020

1 reference

Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis

31 March 2020

1 reference

Human susceptibility and resistance to Norwalk virus infection

31 March 2020

1 reference

A homozygous nonsense mutation (428G-->A) in the human secretor (FUT2) gene provides resistance to symptomatic norovirus (GGII) infections

31 March 2020

1 reference

The Resistance Factor to Plasmodium vivax in Blacks

31 March 2020

1 reference

A homozygous CARD9 mutation in a family with susceptibility to fungal infections

31 March 2020

1 reference

Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity

31 March 2020

1 reference

New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS.

31 March 2020

1 reference

12 December 2020

Tuberculosis in twins: a re-analysis of the Prophit survey

1 reference

12 December 2020

Hepatitis B virus markers in Chinese twins

1 reference

12 December 2020

A twin-family study of susceptibility to poliomyelitis

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRG3114

1 reference

26 August 2017

1 reference

PubMed ID

22310894