(Q37982133)

26 August 2017

title

P53 and its molecular basis to chemoresistance in breast cancer (English)

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26 August 2017

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2

Per Eystein Lønning

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26 August 2017

1

Stian Knappskog

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26 August 2017

language of work or name

English

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publication date

8 February 2012

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Expert Opinion on Therapeutic Targets

26 August 2017

published in

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26 August 2017

volume

16 Suppl 1

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26 August 2017

page(s)

S23-30

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Alteration of topoisomerase II-alpha gene in human breast cancer: association with responsiveness to anthracycline-based chemotherapy

26 August 2017

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Molecular basis for therapy resistance

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Interfaces between the detection, signaling, and repair of DNA damage

21 January 2018

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DNA microarrays identification of primary and secondary target genes regulated by p53.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.640322

Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53

21 January 2018

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The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells

21 January 2018

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A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response

21 January 2018

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p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

21 January 2018

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PUMA, a potent killer with or without p53

21 January 2018

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Transcription-independent pro-apoptotic functions of p53.

21 January 2018

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 January 2018

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Live or let die: the cell's response to p53

21 January 2018

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

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Role of p53 serine 46 in p53 target gene regulation

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Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence

21 January 2018

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Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.

21 January 2018

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Regulation of the p53 transcriptional response by structurally diverse core promoters

21 January 2018

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

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CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer

21 January 2018

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The clinical significance of mutations of the P53 tumour suppressor gene in haematological malignancies

21 January 2018

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Genes causing inherited cancer as beacons to identify the mechanisms of chemoresistance

21 January 2018

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Predictive and prognostic impact of TP53 mutations and MDM2 promoter genotype in primary breast cancer patients treated with epirubicin or paclitaxel

21 January 2018

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TP53 status for prediction of sensitivity to taxane versus non-taxane neoadjuvant chemotherapy in breast cancer (EORTC 10994/BIG 1-00): a randomised phase 3 trial

21 January 2018

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The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer

21 January 2018

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p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients.

21 January 2018

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Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen

21 January 2018

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p53 isoforms can regulate p53 transcriptional activity.

21 January 2018

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ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles

21 January 2018

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The combined status of ATM and p53 link tumor development with therapeutic response

21 January 2018

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Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

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ATM and ATR: networking cellular responses to DNA damage

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Regulation of p53--insights into a complex process

21 January 2018

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 January 2018

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ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

21 January 2018

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A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

21 January 2018

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A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect

21 January 2018

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The p53 orchestra: Mdm2 and Mdmx set the tone

21 January 2018

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Identification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancers

21 January 2018

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The MDM2 Promoter SNP285C/309G Haplotype Diminishes Sp1 Transcription Factor Binding and Reduces Risk for Breast and Ovarian Cancer in Caucasians

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.640322

10.1517/14728222.2011.640322

21 January 2018

Identifiers

DOI

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26 August 2017

1 reference