(Q37983419)

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Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

scientific article published on 10 February 2012

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scholarly article

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Europe PubMed Central

PubMed publication ID

26 August 2017

Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

ubiquitin-proteasome system

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Aaron Ciechanover

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object named as

Aaron Ciechanover

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Europe PubMed Central

PubMed publication ID

26 August 2017

publication date

10 February 2012

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Neurodegenerative Diseases

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Europe PubMed Central

PubMed publication ID

26 August 2017

10

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Europe PubMed Central

PubMed publication ID

26 August 2017

1-4

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

7-22

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Impressions of an organic chemist in biochemistry.

1 reference

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Hitler's gift and the era of biosynthesis

1 reference

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Intracellular protein catabolism and its control during nutrient deprivation and supply

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Cytoplasmic components in hepatic cell lysosomes

1 reference

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Control of enzyme levels in animal tissues

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Intracellular protein degradation in mammalian and bacterial cells: Part 2

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Mechanisms of chaperone-mediated autophagy

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Lysosomes, a meeting point of proteins, chaperones, and proteases

1 reference

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21 January 2018

Functions of lysosomes

1 reference

https://api.crossref.org/works/10.1159%2F000334283

21 January 2018

Diseases of function and stability of haemoglobin

1 reference

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21 January 2018

A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes

1 reference

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21 January 2018

Selective control of the degradation of normal and aberrant proteins in Reuber H35 hepatoma cells

1 reference

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21 January 2018

Turnover of protein in growing and non-growing populations of Escherichia coli

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A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes

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ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation

1 reference

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Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis

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Isolation of bovine thymin: a polypeptide hormone of the thymus

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Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells

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Remarkable similarities of peptide fingerprints of histone 2A and nonhistone chromosomal protein A24

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Isopeptide linkage between nonhistone and histone 2A polypeptides of chromosomal conjugate-protein A24

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21 January 2018

Amino-terminal sequence identity of ubiquitin and the nonhistone component of nuclear protein A24

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A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

1 reference

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N-terminal ubiquitination: more protein substrates join in.

1 reference

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How the ubiquitin-proteasome system controls transcription

1 reference

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Transcriptional regulation by histone ubiquitination and deubiquitination.

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H2B ubiquitylation: the end is in sight

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Conjugation of ubiquitin to denatured hemoglobin is proportional to the rate of hemoglobin degradation in HeLa cells

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21 January 2018

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1 reference

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21 January 2018

ATP serves two distinct roles in protein degradation in reticulocytes, one requiring and one independent of ubiquitin

1 reference

https://api.crossref.org/works/10.1159%2F000334283

21 January 2018

ATP-dependent degradation of ubiquitin-protein conjugates

1 reference

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21 January 2018

Cation-sensitive neutral endopeptidase: isolation and specificity of the bovine pituitary enzyme

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21 January 2018

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin

1 reference

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21 January 2018

Red light-induced formation of ubiquitin-phytochrome conjugates: Identification of possible intermediates of phytochrome degradation.

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21 January 2018

In vivo degradation of a transcriptional regulator: the yeast alpha 2 repressor

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

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Cyclin is degraded by the ubiquitin pathway

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Degradation of nuclear oncoproteins by the ubiquitin system in vitro

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A protein conjugation system essential for autophagy

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21 January 2018

Potential for proteasome inhibition in the treatment of cancer

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

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Proteasomes and their kin: proteases in the machine age

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Enzymic Content of the Mitochondria Fraction

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Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates

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11 October 2022

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Molecular mechanisms of bitter and sweet taste transduction

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Some characteristics of the alanine aminotransferase- and arginase-inactivating system of lysosomes

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Attempts to Map a Process Evolution of Peptide Biosynthesis

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The complete amino acid sequence of ubiquitin, an adenylate cyclase stimulating polypeptide probably universal in living cells

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Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

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Observations on intracellular protein catabolism studied in vitro

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The effect of protease inhibitors and decreased temperature on the degradation of different classes of proteins in cultured hepatocytes

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Tissue fractionation studies. 4. Comparative study of the binding of acid phosphatase, β-glucuronidase and cathepsin by rat-liver particles

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Effect of ATP on Protein Degradation in Rat Liver Lysosomes

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Proteolysis: from the lysosome to ubiquitin and the proteasome

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Decrease in uH2A (protein A24) of a mouse temperature‐sensitive mutant

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Studies on the induced synthesis of β-galactosidase in Escherichia coli: The kinetics and mechanism of sulfur incorporation

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Identifiers

10.1159/000334283

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

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