(Q37984182)

26 August 2017

title

Targeting GRK2 by gene therapy for heart failure: benefits above β-blockade (English)

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26 August 2017

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5

H A Katus

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26 August 2017

J Reinkober

1

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26 August 2017

H Tscheschner

2

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26 August 2017

S T Pleger

3

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26 August 2017

P Most

4

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26 August 2017

W J Koch

6

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26 August 2017

P W J Raake

7

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26 August 2017

publication date

16 February 2012

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26 August 2017

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26 August 2017

volume

19

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26 August 2017

issue

6

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26 August 2017

page(s)

686-693

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Seven-transmembrane-spanning receptors and heart function

26 August 2017

cites work

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G protein-coupled receptor kinases in normal and failing myocardium

21 January 2018

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GRK2 as a novel gene therapy target in heart failure.

21 January 2018

1 reference

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure

21 January 2018

1 reference

New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy

21 January 2018

1 reference

Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation

21 January 2018

1 reference

Cardiac oxidative stress in acute and chronic isoproterenol-infused rats

21 January 2018

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Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

21 January 2018

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Regulation of G protein-coupled receptor kinases

21 January 2018

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Phosphorylation-independent regulation of metabotropic glutamate receptor signaling by G protein-coupled receptor kinase 2.

21 January 2018

1 reference

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

21 January 2018

1 reference

Ventricular hypertrophy plus neurohumoral activation is necessary to alter the cardiac beta-adrenoceptor system in experimental heart failure

21 January 2018

1 reference

Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction

21 January 2018

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G-protein-coupled receptor kinase activity is increased in hypertension

21 January 2018

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Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase

21 January 2018

1 reference

The myocardial beta-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats.

21 January 2018

1 reference

Mechanical unloading restores beta-adrenergic responsiveness and reverses receptor downregulation in the failing human heart

21 January 2018

1 reference

Reversal of impaired myocardial beta-adrenergic receptor signaling by continuous-flow left ventricular assist device support

21 January 2018

1 reference

Dynamic changes in lymphocyte GRK2 levels in cardiac transplant patients: a biomarker for left ventricular function.

21 January 2018

1 reference

Viral-based myocardial gene therapy approaches to alter cardiac function

21 January 2018

1 reference

Gene therapy in heart failure

21 January 2018

1 reference

Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity

21 January 2018

1 reference

Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure

21 January 2018

1 reference

Mechanisms and models in heart failure: A combinatorial approach

21 January 2018

1 reference

G-protein-coupled receptor kinase activity in human heart failure: effects of beta-adrenoceptor blockade

21 January 2018

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Patients with end-stage congestive heart failure treated with beta-adrenergic receptor antagonists have improved ventricular myocyte calcium regulatory protein abundance

21 January 2018

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Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade

21 January 2018

1 reference

Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure

21 January 2018

1 reference

Beta-adrenoceptor blocker treatment and the cardiac beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in chronic heart failure

21 January 2018

1 reference

Current role of beta-adrenergic blockers in the management of chronic heart failure

21 January 2018

1 reference

Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy

21 January 2018

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High-dose recombinant apolipoprotein A-I(milano) mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein e-deficient mice. Potential implications for acute plaque stabilization

21 January 2018

1 reference

Ventricular dysfunction after cardioplegic arrest is improved after myocardial gene transfer of a beta-adrenergic receptor kinase inhibitor

21 January 2018

1 reference

Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure

21 January 2018

1 reference

Differential myocardial gene expression in the development and rescue of murine heart failure

21 January 2018

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Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

21 January 2018

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Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure

21 January 2018

1 reference

Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts

21 January 2018

1 reference

Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model

21 January 2018

1 reference

G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure

21 January 2018

1 reference

The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition.

21 January 2018

1 reference

Comparative hemodynamic, left ventricular functional, and antiadrenergic effects of chronic treatment with metoprolol versus carvedilol in the failing heart

21 January 2018

1 reference

Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression

21 January 2018

1 reference

Effects of two Gbetagamma-binding proteins--N-terminally truncated phosducin and beta-adrenergic receptor kinase C terminus (betaARKct)--in heart failure

21 January 2018

1 reference

Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure

21 January 2018

1 reference

7 January 2021

Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq.

1 reference

7 January 2021

Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding

1 reference

7 January 2021

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart

1 reference

7 January 2021

Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure

1 reference

7 January 2021

Expression of GRK2 is increased in the left ventricles of cardiomyopathic hamsters

1 reference

7 January 2021

Activation of beta-adrenergic receptor kinase during myocardial ischemia

1 reference

7 January 2021

Treatment of chronic heart failure with β-adrenergic receptor antagonists: a convergence of receptor pharmacology and clinical cardiology

1 reference

7 January 2021

Effects of metoprolol on myocardial beta-adrenoceptors and Gi alpha-proteins in patients with congestive heart failure

1 reference

7 January 2021

Increased beta-receptor density and improved hemodynamic response to catecholamine stimulation during long-term metoprolol therapy in heart failure from dilated cardiomyopathy

1 reference

7 January 2021

In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction

1 reference

7 January 2021

AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model

1 reference

7 January 2021

Identifiers

DOI

10.1038/GT.2012.9

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26 August 2017

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