(Q37990285)

26 August 2017

PP2A holoenzymes negatively and positively regulate cell cycle progression by dephosphorylating pocket proteins and multiple CDK substrates (English)

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26 August 2017

Alison Kurimchak

1

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PubMed ID

22387205

26 August 2017

Xavier Graña

series ordinal

2

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PubMed ID

22387205

26 August 2017

language of work or name

English

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publication date

22 February 2012

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26 August 2017

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26 August 2017

499

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26 August 2017

1

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26 August 2017

1-7

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Greatwall maintains mitosis through regulation of PP2A.

26 August 2017

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12 December 2020

Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis

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12 December 2020

Targets of the cyclin-dependent kinase Cdk1

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12 December 2020

Protein phosphatase 2A regulatory subunits and cancer.

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12 December 2020

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

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12 December 2020

Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase

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12 December 2020

PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells

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12 December 2020

p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity

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12 December 2020

Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit

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12 December 2020

A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130

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12 December 2020

Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells

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12 December 2020

Finishing mitosis, one step at a time.

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12 December 2020

High molecular weight protein phosphatase type 1 dephosphorylates the retinoblastoma protein

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12 December 2020

Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes

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12 December 2020

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12 December 2020

Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing

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12 December 2020

A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation

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12 December 2020

cDNA cloning of a novel B subunit of Xenopus protein phosphatase 2A and its biological activity in oocytes

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12 December 2020

Interaction of PP2A catalytic subunit with Rb2/p130 is required for all-trans retinoic acid suppression of ovarian carcinoma cell growth

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12 December 2020

Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts

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12 December 2020

p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

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12 December 2020

Normal regulation of Rbf1/E2f1 target genes in Drosophila type 1 protein phosphatase mutants.

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12 December 2020

PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated beta-catenin dephosphorylation.

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12 December 2020

An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein

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12 December 2020

Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein

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12 December 2020

Protein phosphatases take the mitotic stage.

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12 December 2020

Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo

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12 December 2020

Phosphatases: providing safe passage through mitotic exit

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12 December 2020

PP2A-mediated dephosphorylation of p107 plays a critical role in chondrocyte cell cycle arrest by FGF

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12 December 2020

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12 December 2020

Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A.

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12 December 2020

Inhibition of cdc2 activation by INH/PP2A.

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12 December 2020

PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1.

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12 December 2020

PR72, a novel regulator of Wnt signaling required for Naked cuticle function

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12 December 2020

PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle

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12 December 2020

Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130.

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12 December 2020

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

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12 December 2020

Shared role of the pRB-related p130 and p107 proteins in limb development

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12 December 2020

The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.

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12 December 2020

WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A

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12 December 2020

Downregulation of the phosphatase nuclear targeting subunit (PNUTS) triggers pRB dephosphorylation and apoptosis in pRB positive tumor cell lines

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12 December 2020

The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites

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12 December 2020

Rapid dephosphorylation of p107 following UV irradiation.

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12 December 2020

Serine/threonine phosphatases: mechanism through structure

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12 December 2020

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit

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12 December 2020

Characterization of the mitotic phase pRb-directed protein phosphatase activity

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12 December 2020

From promiscuity to precision: protein phosphatases get a makeover

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12 December 2020

The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A

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12 December 2020

Structure of the protein phosphatase 2A holoenzyme

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12 December 2020

Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation

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12 December 2020

Specific enzymatic dephosphorylation of the retinoblastoma protein

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12 December 2020

MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR.

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12 December 2020

PP2A interaction with Rb2/p130 mediates translocation of Rb2/p130 into the nucleus in all-trans retinoic acid-treated ovarian carcinoma cells

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12 December 2020

A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC

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12 December 2020

Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes

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12 December 2020

Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

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12 December 2020

SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells

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12 December 2020

B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation

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12 December 2020

p107 in the public eye: an Rb understudy and more

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12 December 2020

G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression

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12 December 2020

Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A.

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12 December 2020

FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest

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12 December 2020

10.1016/J.GENE.2012.02.015

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22387205