(Q35805056)

10 August 2017

The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2). (English)

1 reference

10 August 2017

1 reference

1 reference

Jiri Lukas

2

0 references

author name string

Donato Tedesco

series ordinal

1

1 reference

PMCID

187481

10 August 2017

Steven I Reed

series ordinal

3

1 reference

10 August 2017

1 November 2002

1 reference

10 August 2017

1 reference

10 August 2017

16

1 reference

10 August 2017

2946-2957

1 reference

10 August 2017

22

1 reference

PMCID

187481

describes a project that uses

10 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC187481/fullTextXML

inferred from PubMed Central ID database lookup

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Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

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Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

11 July 2018

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The retinoblastoma gene family in differentiation and development.

11 July 2018

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SCF and Cullin/Ring H2-based ubiquitin ligases

11 July 2018

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p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

11 July 2018

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

11 July 2018

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Regulation of E2F: a family of transcription factors involved in proliferation control

11 July 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

11 July 2018

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Substrate targeting in the ubiquitin system

11 July 2018

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Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

11 July 2018

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Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

11 July 2018

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Transcriptional repression of the E2F-1 gene by interferon-alpha is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes

11 July 2018

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A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells

11 July 2018

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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

11 July 2018

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SCF and APC: the Yin and Yang of cell cycle regulated proteolysis

11 July 2018

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The COOH-terminal region of pRb2/p130 binds to histone deacetylase 1 (HDAC1), enhancing transcriptional repression of the E2F-dependent cyclin A promoter

11 July 2018

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Differential expression of Rb2/p130 and p107 in normal human tissues and in primary lung cancer

11 July 2018

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Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene.

11 July 2018

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11 July 2018

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The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase

11 July 2018

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Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor

11 July 2018

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The regulation of E2F by pRB-family proteins

11 July 2018

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Differential regulation of the retinoblastoma family of proteins during cell proliferation and differentiation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Control of retinoblastoma protein-independent hematopoietic cell cycle by the pRB-related p130.

11 July 2018

1 reference

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New perspectives on retinoblastoma family functions in differentiation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Proteolysis and the G1-S transition: the SCF connection

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Regulation of cell proliferation by the E2F transcription factors

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

11 July 2018

1 reference

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Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication

11 July 2018

1 reference

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Regulation of CDK/cyclin complexes during the cell cycle

11 July 2018

1 reference

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RB and hbrm cooperate to repress the activation functions of E2F1

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Regulation and expression of retinoblastoma proteins p107 and p130 during 3T3-L1 adipocyte differentiation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Retinoblastoma protein family in cell cycle and cancer: a review

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Episomal vectors rapidly and stably produce high-titer recombinant retrovirus

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

MyoD induces retinoblastoma gene expression during myogenic differentiation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Principles of CDK regulation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Inhibitors of mammalian G1 cyclin-dependent kinases

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

The retinoblastoma protein and cell cycle control

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs).

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=187481

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

25 September 2018

1 reference

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The retinoblastoma gene family: cousins with overlapping interests.

25 September 2018

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Role of pRB2/p130 in cellular growth regulation

25 September 2018

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12 December 2020

Immunohistochemical investigation of new suppressor oncogene p130 in oral squamous cell carcinoma

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12 December 2020

Differential expression of the retinoblastoma gene family members pRb/p105, p107, and pRb2/p130 in lung cancer

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12 December 2020

Differential expression of the retinoblastoma gene family members in choroidal melanoma: prognostic significance

1 reference

12 December 2020

A Unique Domain of pRb2/p130 Acts as an Inhibitor of Cdk2 Kinase Activity

1 reference

12 December 2020

Expression of the retinoblastoma-related gene Rb2/p130 correlates with clinical outcome in endometrial cancer

1 reference

12 December 2020

Toward an understanding of the functional complexity of the E2F and retinoblastoma families

1 reference

12 December 2020

The RB family of cell cycle regulatory factors

1 reference

12 December 2020

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

1 reference

12 December 2020

A CDE/CHR-like element mediates repression of transcription of the mouse RB2 (p130) gene

1 reference

12 December 2020

Cdk2-dependent phosphorylation and functional inactivation of the pRB-related p130 protein in pRB(-), p16INK4A(+) tumor cells

1 reference

12 December 2020

Identifiers

DOI

10.1101/GAD.1011202

1 reference

10 August 2017

1 reference

10 August 2017

1 reference

PMCID

187481