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Palmitoylation of Hedgehog proteins
scientific article published on January 2012
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scholarly article
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Europe PubMed Central
PMCID
4214369
retrieved
26 August 2017
title
Palmitoylation of Hedgehog proteins
(English)
1 reference
stated in
Europe PubMed Central
PMCID
4214369
retrieved
26 August 2017
author name string
John A Buglino
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
4214369
retrieved
26 August 2017
Marilyn D Resh
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
4214369
retrieved
26 August 2017
publication date
1 January 2012
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stated in
Europe PubMed Central
PMCID
4214369
retrieved
26 August 2017
published in
Vitamins and Hormones
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stated in
Europe PubMed Central
PMCID
4214369
retrieved
26 August 2017
volume
88
1 reference
stated in
Europe PubMed Central
PMCID
4214369
retrieved
26 August 2017
page(s)
229-252
1 reference
stated in
Europe PubMed Central
PMCID
4214369
retrieved
26 August 2017
cites work
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
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PubMed Central
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6 September 2017
Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog
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PubMed Central
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6 September 2017
The full-length unprocessed hedgehog protein is an active signaling molecule
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stated in
PubMed Central
reference URL
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6 September 2017
The mutational spectrum of holoprosencephaly-associated changes within the SHH gene in humans predicts loss-of-function through either key structural alterations of the ligand or its altered synthesis
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PubMed Central
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6 September 2017
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
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PubMed Central
reference URL
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6 September 2017
Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides.
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6 September 2017
Ghrelin octanoylation mediated by an orphan lipid transferase
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PubMed Central
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6 September 2017
Lipid-independent secretion of a Drosophila Wnt protein
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PubMed Central
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6 September 2017
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
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PubMed Central
reference URL
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6 September 2017
Patched, the receptor of Hedgehog, is a lipoprotein receptor
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PubMed Central
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6 September 2017
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion
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PubMed Central
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6 September 2017
Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling
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PubMed Central
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6 September 2017
Palmitoylation of ligands, receptors, and intracellular signaling molecules
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6 September 2017
Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development
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6 September 2017
Ghrelin and the short- and long-term regulation of appetite and body weight
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PubMed Central
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6 September 2017
Cholesterol modification restricts the spread of Shh gradient in the limb bud.
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PubMed Central
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6 September 2017
GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor
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6 September 2017
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.
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PubMed Central
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6 September 2017
Differential range and activity of various forms of the Hedgehog protein
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PubMed Central
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6 September 2017
Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway
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PubMed Central
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6 September 2017
Lipoprotein particles are required for Hedgehog and Wingless signalling
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PubMed Central
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6 September 2017
The human Kv1.1 channel is palmitoylated, modulating voltage sensing: Identification of a palmitoylation consensus sequence
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PubMed Central
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6 September 2017
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
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PubMed Central
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6 September 2017
Tissue repair and stem cell renewal in carcinogenesis
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6 September 2017
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6 September 2017
Palmitoylation of intracellular signaling proteins: regulation and function
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PubMed Central
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6 September 2017
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
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PubMed Central
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6 September 2017
The N-terminal SH4 region of the Src family kinase Fyn is modified by methylation and heterogeneous fatty acylation: role in membrane targeting, cell adhesion, and spreading
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6 September 2017
Human acyl-coenzyme A:cholesterol acyltransferase expressed in chinese hamster ovary cells: membrane topology and active site location
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6 September 2017
Wnt proteins are lipid-modified and can act as stem cell growth factors
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6 September 2017
Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling
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PubMed Central
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6 September 2017
Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae.
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6 September 2017
CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes
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6 September 2017
Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases
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6 September 2017
The biology and enzymology of protein N-myristoylation
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6 September 2017
Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
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6 September 2017
The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides
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6 September 2017
Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction
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6 September 2017
The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly
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6 September 2017
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
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6 September 2017
Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation
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6 September 2017
A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling
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6 September 2017
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
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6 September 2017
Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
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6 September 2017
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
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6 September 2017
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
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6 September 2017
LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
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6 September 2017
Identification of a palmitic acid-modified form of human Sonic hedgehog
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6 September 2017
Unique regulatory properties of the type 2a Ca2+ channel beta subunit caused by palmitoylation
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6 September 2017
Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins
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6 September 2017
The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing
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6 September 2017
Cholesterol modification of hedgehog signaling proteins in animal development
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6 September 2017
Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain
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6 September 2017
Autoproteolysis in hedgehog protein biogenesis
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6 September 2017
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
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PubMed Central
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6 September 2017
Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants.
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6 September 2017
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
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6 September 2017
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis
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6 September 2017
HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo
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6 September 2017
Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage.
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6 September 2017
Mutations affecting segment number and polarity in Drosophila
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6 September 2017
All ras proteins are polyisoprenylated but only some are palmitoylated
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6 September 2017
Enhanced potency of human Sonic hedgehog by hydrophobic modification.
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6 September 2017
Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling.
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14 September 2017
Regulation of Ras localization by acylation enables a mode of intracellular signal propagation.
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14 September 2017
Galpha(s) is palmitoylated at the N-terminal glycine
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14 September 2017
A paracrine requirement for hedgehog signalling in cancer
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14 September 2017
Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog
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PubMed Central
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14 September 2017
Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
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14 September 2017
Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a
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PubMed Central
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14 September 2017
Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion
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14 September 2017
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
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14 September 2017
Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine
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PubMed Central
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14 September 2017
The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor
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14 September 2017
A freely diffusible form of Sonic hedgehog mediates long-range signalling
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28 September 2017
Activation of the beta(2)-adrenergic receptor-Galpha(s) complex leads to rapid depalmitoylation and inhibition of repalmitoylation of both the receptor and Galpha(s).
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
28 September 2017
Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
28 September 2017
Ghrelin O-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
23 June 2018
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
23 June 2018
A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
23 June 2018
The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
23 June 2018
N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
23 June 2018
Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
23 June 2018
Drosophila hedgehog acts as a morphogen in cellular patterning.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
23 June 2018
The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
23 June 2018
Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
23 June 2018
The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
23 June 2018
Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
23 June 2018
Sonic hedgehog shedding results in functional activation of the solubilized protein.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Identification of membrane O-acyltransferase family motifs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Nanoscale organization of hedgehog is essential for long-range signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
In vivo role of lipid adducts on Wingless
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
A family of eukaryotic lysophospholipid acyltransferases with broad specificity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Drosophila segment polarity gene product porcupine stimulates the posttranslational N-glycosylation of wingless in the endoplasmic reticulum
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Distinct roles of Central missing and Dispatched in sending the Hedgehog signal
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Depalmitoylation of endothelial nitric-oxide synthase by acyl-protein thioesterase 1 is potentiated by Ca(2+)-calmodulin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Teratogen-mediated inhibition of target tissue response to Shh signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Secretion of the amino-terminal fragment of the hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214369
retrieved
31 August 2018
Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22391306
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/B978-0-12-394622-5.00010-9
1 reference
stated in
Europe PubMed Central
PMCID
4214369
retrieved
26 August 2017
PMCID
4214369
1 reference
stated in
Europe PubMed Central
PMCID
4214369
retrieved
26 August 2017
PubMed ID
22391306
1 reference
stated in
Europe PubMed Central
PMCID
4214369
retrieved
26 August 2017
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